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Recent News and Articles on the Keywords: liver cancer + effective treatment + cancer  Related to the article below (Last Update: 5/12/2008)

New Treatments Help Fight Liver, Colon Cancer
Forbes, NY - Apr 14, 2008
In the study, 34 patients with advanced liver cancer were given Sutent daily for four weeks with two weeks off before the next round of treatment. ...

Natural News.com
Success Against HIV and Cancer in South Africa (Oleander Series ...
Natural News.com, AZ - May 10, 2008
to date, the only patients that did not make it on the oleander mix were three patients with very advanced cancer that had metastasized to the liver and who ...
Prevent and Protect
Washington Post, United States - May 8, 2008
So, in addition to being an effective treatment for aging skin, it is an essential part of a good skin care maintenance regimen. I usually recommend the use ...
Potential Viral Therapy Weapon For Difficult Cancers Is Safe And ...
Science Daily (press release) - Apr 22, 2008
This new finding may add to the growing arsenal of so called oncolytic viruses under development as novel cancer treatments, especially for difficult, ...
Estradiol Effective For Hot Flashes Linked Menopause
eMaxHealth.com, NC - May 7, 2008
Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. ...
Fighting the Cancer menaceThe African,Oxford Initiative
Modern Ghana, Ghana - Apr 30, 2008
Early detection of cancer is based on the observation, that treatment is more effective when cancer is detected early. The aim is to detect the cancer when ...
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Devon 24, UK - May 6, 2008
He is campaigning for political parties to examine more effective ways of funding the treatment of cancer. In the meantime, he feels Mr Talbot-Thompson, 58, ...

BBC News
Scientists solve riddle of arsenic cancer treatment
Guardian, UK - Apr 13, 2008
"Knowing the specific molecules involved allows us to work on creating more targeted and effective cancer drugs with fewer side effects. ...
Experts unravel arsenic mystery The Press Association
all 17 news articles »
Gypsy Moth spraying raises some concerns
Oakville Beaver, Canada -
During current re-evaluation of Btk, Health Canada also tested the pesticide in relation to cancer, birth defects and other health problems and paid ...
Invasive Measures May Improve Outcome for Patients with Liver Cancer
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Source: Google News

… Resections Are Safe and Effective Treatment for Recurrent Hepatic Metastases from Colorectal Cancer … -
H Petrowsky, M Gonen, W Jarnagin, M Lorenz, R … - Annals of Surgery, 2002 - annalsofsurgery.com
... Second Liver Resections Are Safe and Effective Treatment for Recurrent Hepatic
Metastases from Colorectal Cancer: A Bi-institutional Analysis. ...

Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant Chemotherapy. -
H Bismuth, R Adam, F L?vi, C Farabos, F Waechter, … - Annals of Surgery, 1996 - annalsofsurgery.com
... half of all patients with colorectal cancer present at ... patients with colorectal
metastases to the liver.1,2 ... agents, mainly 5-fluorouracil, is effective in some ...

… Surgical Indications in the Treatment of Liver Metastases From Colorectal Cancer: Long-Term Results … -
M Minagawa, M Makuuchi, G Torzilli, T Takayama, S … - Annals of Surgery, 2000 - annalsofsurgery.com
... conclusion, the indications for liver resection for metastases from colorectal cancer
are currently ... mandatory for performing safe and effective treatment. ...

TNF-and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-kappa B -
CY Wang, MW Mayo, AS Baldwin Jr - Science, 1996 - sciencemag.org
... embryonically from extensive apoptosis within the liver (2). Many ... of tumors to provide
a more effective treatment against resistant forms of cancer. ...

Treatment of uveal melanoma metastatic to the liver: a review of the MD Anderson Cancer Center … -
AY Bedikian, SS Legha, G Mavligit, CH Carrasco, S … - Cancer, 1995 - ncbi.nlm.nih.gov
... were treated at MD Anderson Cancer Center between ... chemotherapies, and chemoembolization
of liver metastases ... was the most effective treatment, inducing responses ...

Letrozole Is More Effective Neoadjuvant Endocrine Therapy Than Tamoxifen for ErbB-1-and/or ErbB-2- … -
MJ Ellis, A Coop, B Singh, L Mauriac, A Llombert- … - Journal of Clinical Oncology, 2001 - jco.ascopubs.org
... Adequate hematologic, renal, and liver function and a life expectancy of at ... of the
two might be more effective against this breast cancer subtype than ...

Role of liver transplantation in cancer therapy. -
S Iwatsuki, RD Gordon, BW Shaw Jr, TE Starzl - Annals of Surgery, 1985 - pubmedcentral.nih.gov
... In future trials, additional effective anticancer therapy will be needed to ... RL,
Edmondson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of ... Cancer. ...

… carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. -
S Arii, Y Yamaoka, S Futagawa, K Inoue, K … - Hepatology, 2000 - ncbi.nlm.nih.gov
... of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas:
a retrospective and nationwide survey in Japan. The Liver Cancer Study Group ...

Limited hepatic resection effective for selected cirrhotic patients with primary liver cancer. -
T Kanematsu, K Takenaka, T Matsumata, T Furuta, K … - Annals of Surgery, 1984 - pubmedcentral.nih.gov
... notice. Limited hepatic resection effective for selected ... evaluation of hepatoma for
surgical treatment. ... M, Inokuchi K. Minute liver cancer and concomitant ...

… Endothelial Growth Factor Receptor Inhibits the Growth of Colon Cancer Liver Metastasis and Induces … -
RM Shaheen, DW Davis, W Liu, BK Zebrowski, MR … - Cancer Research, 1999 - AACR
... lead to a survival advantage for the treatment groups ... present, there is a lack of
effective systemic therapies ... in the management of colon cancer liver metastases ...

Source: Google Scholar

Advance In The Search For An Effective Treatment For Liver Cancer
Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics. Using a newly available monoclonal antibody, they demonstrated significant reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer (HCC) cell lines. According to the researchers, this finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.

Most cases of HCC are secondary to either a viral hepatitis infection or cirrhosis of the liver. Despite recent advances, it remains a disease of grim prognosis due to the poorly understood mechanism of how the disease originates and spreads. Most patients live only a short time after diagnosis.
Based on previous studies showing that some pathways that were previously thought to be active only during fetal liver development, particularly the class III receptor tyrosine kinase (RTK) family pathway, became highly active again in the liver of HCC patients, Satdarshan P. Singh Monga, M.D., associate professor, division of cellular and molecular pathology and colleagues at the University of Pittsburgh School of Medicine, obtained rat and human liver cancer cell lines and analyzed them for level of expression of an RTK protein known as platelet-derived growth factor receptor-alpha, or PDGFR'. The investigators also analyzed the cells for their level of activation of the PDGFR' gene.

At an early fetal stage of liver development in the mouse, the investigators found that the level of expression of PDGFR' was 37 times higher compared to later stages of development in the adult mouse liver. They also found significantly higher levels of PDGFR' in rat and human liver cancer cell lines as compared to normal cells in culture.

Dr. Monga's group then treated human and mouse liver cancer cell lines with a monoclonal antibody targeted against PDGFR'. It resulted in a significant decrease in tumor cell proliferation and a marked increase in tumor cell death. In fact, all tumor cell lines experienced significant decreases in proliferation in response to the monoclonal antibody and there was a 4- to 18-fold increase in programmed cell death, or apoptosis, among the cancer cell lines compared to normal control cells.

According to Dr. Monga, these results suggest that PDGFR' offers an important new therapeutic target for the treatment of HCC.

"We are very excited because this is the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how they work. We now have identified a pathway that appears to be overly active in more than 70 percent of the cancers we examined and, when targeted, leads to significant reduction in tumor cell proliferation and survival," said Dr. Monga.
More importantly, targeting the PDGFR' pathway in liver cancer cells does not appear to affect normal liver cells, making the treatment relatively non-toxic. "Normally, regenerating liver cells are not exclusively dependent on this pathway, and it is not overly active in other types of cells. So this monoclonal antibody is a highly targeted treatment for this disease," he added.

Furthermore, because high expression of PDGFR' has been detected in a variety of tumors, such as skin cancer, brain tumors, gastrointestinal tumors, prostate tumors, ovarian cancer and leukemia, Dr. Monga believes these findings could have much broader applications.

This research was funded by grants from the American Cancer Society and the National Institutes of Health as well as the Cleveland Foundation and the Rango's Fund for Enhancement of Pathology Research.

In addition to Dr. Monga, other researchers involved in the study included Peggy Stock, Xinping Tan and Amanda Micsenyi, all in the department of pathology, University of Pittsburgh School of Medicine; Dulabh Monga, department of human oncology, Allegheny General Hospital, Pittsburgh; and Nick Loizos, ImClone Systems, Inc., New York.

Source: Jim Swyers
University of Pittsburgh Schools of the Health Sciences
 
 
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