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Recent News and Articles on the Keywords: breast cancer + preclinical research + new  Related to the article below (Last Update: 5/12/2008)

GTx, Inc. Reports First Quarter 2008 Financial Results
WELT ONLINE, Germany -
In 2006, GTx and Ipsen Group entered into a development and collaboration agreement for toremifene citrate in all indications except breast cancer for ...GTXI
Bioniche Updates re: Mycobacterial Cell Wall Technology Platform
PR Newswire (press release), NY -
These include colon, stomach, appendix, biliary, pancreatic and breast cancer, as well as cases of mesothelioma, in which a significant proportion of ...TSE:BNC
Bionovo Reports First Quarter 2008 Financial Results
FOXBusiness - May 10, 2008
Bionovo presented data on two additional preclinical anti-cancer drug candidates -- BN107 and BN108 -- at the American Association of Cancer Research (AACR) ...BNVI
New Preclinical Data Show Significant Anti-Tumor Activity ...
FOXBusiness - Apr 13, 2008
IPI-926 has demonstrated biological activity in multiple preclinical animal models of cancer. Infinity anticipates commencing clinical trials of IPI-926 in ...
AVEO Pharmaceuticals? Novel Triple VEGF Receptor Inhibitor Shows ... Business Wire (press release)
all 21 news articles »  INFI
Infinity Highlights Promising Preclinical Hedgehog Data and ...
Primenewswire (press release), CA - May 5, 2008
In two additional AACR abstracts, data were presented that show the activity of retaspimycin in preclinical models of both breast cancer and melanoma. ...INFI
Abraxis BioScience Presents New Preclinical Data Demonstrating ...
Earthtimes, UK - Apr 15, 2008
These results confirm a synergistic effect of ABRAXANE (nab-paclitaxel) and Avastin combination on metastasis in breast cancer previously presented orally ...
Johnson & Johnson through its subsidiary in South Korea has ...
PharmaLive.com (press release), PA - May 8, 2008
Yondelis? is also being studied in solid tumours with high incidence and prevalence in the population, such as prostate, breast and lung cancer. ...JNJ
Measuring medicine: How new technologies could help doctors ...
EurekAlert (press release), DC - Apr 16, 2008
Researchers report a new, noninvasive method for measuring circulating tumor cells in patients with breast cancer, information which can be used to predict ...
Health disparities: genetics plays an important role in cancer ...
EurekAlert (press release), DC - Apr 15, 2008
?We are intrigued with these findings, which we are continuing to research.? A tracking and feedback registry following breast cancer surgery reduces racial ...
Micromet Enrolls First Patient in a Phase 1 Clinical Trial with ...
FOXBusiness - Apr 23, 2008
Additionally, EpCAM has been found on cancer stem cells of colon, breast, prostate and pancreas cancers. Cancer stem cells are believed to cause metastases ...MITI
Source: Google News

A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human … -
W Yue - Cancer Research, 1994 - AACR
... of Aromatase (CYP19) Expression in Breast Cancer Cells through a ... Home page, Clin
Cancer Res Home page A ... and BJ Long Predictions from a Preclinical Model: Studies ...

Mechanism-Based Target Identification and Drug Discovery in Cancer Research -
JB Gibbs - Science, 2000 - sciencemag.org
... In cancer research, the choice of target is often ... the role of estrogen in breast
cancer and oncogenes ... toxicity to tumor cells in preclinical models, subsequent ...

… in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.
K Yu, L Toral-Barza, C Discafani, WG Zhang, J … - Endocr Relat Cancer, 2001 - ncbi.nlm.nih.gov
... effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. ...
Wyeth-Ayerst Research, Department of Oncology, 401 North Middletown Road ...

… Operable Breast Cancer: Results From the European Organization for Research and Treatment of Cancer … -
JA van der Hage, CJH van de Velde, JP Julien, M … - Journal of Clinical Oncology, 2001 - jcojournal.org
... EORTC Manual for Clinical Research in Breast ... of preoperative chemotherapy based on
preclinical data are not exerted in primary operable breast cancer patients. ...

… Studies with the Farnesyl Protein Transferase Inhibitor R115777 in Human Breast Cancer -
LR Kelland, V Smith, M Valenti, L Patterson, PA … - Clinical Cancer Research, 2001 - AACR
... 2001 ? 2001 American Association for Cancer Research ... Preclinical Antitumor Activity
and Pharmacodynamic Studies with ... Inhibitor R115777 in Human Breast Cancer. ...

… antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer … -
J Baselga, L Norton, J Albanell, YM Kim, J … - Cancer Res, 1998 - ncbi.nlm.nih.gov
... Kettering Cancer Center, New York, New York 10021 ... HER2, inhibits the growth of breast
cancer cells overexpressing ... We explored in preclinical models its capacity ...

… Activation and Apoptosis by Flavopiridol on Paclitaxel-treated Human Gastric and Breast Cancer … -
M Motwani, TM Delohery, GK Schwartz - Clinical Cancer Research, 1999 - AACR
... Experimental Therapeutics, Preclinical Pharmacology. ... treated Human Gastric and Breast
Cancer Cells 1. ... Facility [TMD], Memorial Sloan-Kettering Cancer Center, New ...

… and in combination with Hstandard of care? therapeutic agents for the treatment of breast cancer -
TJ Abrams, LJ Murray, E Pesenti, V Walker Holway, … - Molecular Cancer Therapeutics, 2003 - AACR
... and Methods Animals The MX-1 human breast cancer xenograft studies were performed
at the preclinical contract research organization Piedmont ...

… Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor … -
N Suh, WW Lamph, AL Glasebrook, TA Grese, AD … - Clinical Cancer Research, 2002 - AACR
... for Cancer Research Experimental Therapeutics, Preclinical Pharmacology. Prevention
and Treatment of Experimental Breast Cancer with the Combination of a New ...

Translating basic cancer research into new cancer therapeutics -
P Workman, SB Kaye - Trends in Molecular Medicine, 2002 - Elsevier
... result of adjuvant drug treatment of breast and colorectal ... CDK inhibitors are now
entering preclinical and clinical ... control or induce apoptosis in cancer cells ...

Source: Google Scholar

Breast Cancer : A New Preclinical Research Tool
At the Institut Curie, Inserm researchers and physicians have established the largest ever panel of human breast cancer xenografts in animal models. Because of their similarity to patient tumors, these models are an exceptional tool for testing the efficacy of new drugs, adapting treatments to tumor characteristics, unraveling resistance to certain treatments, and as a result limiting the need for clinical trials in patients. Institut Curie and Inserm medical oncologists, surgeons, pathologists and biologists collaborated on this work on mouse models which can now be extended to other types of cancers. The 25 breast tumor models are described in a study published in the 1 July 2007 issue of Clinical Cancer Research.
To help clinicians in their search for more effective treatments, Marie-France Poupon and her team in Institut Curie Inserm Unit 612 "Genotoxicology, signaling and experimental radiotherapy" have developed the largest ever series of human breasts cancers grafted into mice. This six-year study would not have been successful without close collaboration between Institut Curie and Inserm medical oncologists, surgeons, pathologists, and biologists.

These breast cancer xenografts in mice reproduce the genetic, genomic, and histological characteristics of the patient-derived tumor tissues. So they recapitulate features of the original tumors, such as overexpression of HER2 receptors, absence or presence of estrogen receptors, mutation of P53, and react identically to chemotherapy.

Twenty-five models of breast tumors in mice of different biological profiles have been established. These models are an excellent preclinical research tool and can be used to test the efficacy of new drugs and novel therapeutic combinations, as well as analyze the response to treatment and adapt it to the tumor characteristics. This will help in the design of clinical trials and hasten the development of new treatments.

This work is continuing within the framework of the creation of a Preclinical Investigation Laboratory in the Translational Research Department at the Institut Curie, with a view to extending this series of tumor models to other types of cancers, such as pediatric cancers, melanoma, lung cancer, ovarian cancer, and cancers of the bronchi, prostate, and colon.

Breast cancer

Breast cancer is the most frequent cancer in women and affects one in ten women in the developed world. Every year in France there are 42 000 new cases. Between 1980 and 2000, the number of cases increased by almost 60%, largely as a result of increasingly efficient detection and because people are living longer. Breast cancer is most commonly detected in women aged between 50 and 69 years of age (half of all cases), but can occur at any age, albeit very rarely before the age of 25. Mortality has declined because of earlier detection and improved treatments combining surgery, radiotherapy, and chemotherapy, depending on the tumor characteristics. When the diagnosis is made early enough, conservative surgery is possible: the tumor is removed and the breast conserved. When the tumor is larger, or is accompanied by extensive precancerous lesions, it is sometimes essential to remove the breast (mastectomy).
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http://www.curie.fr
 
 
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