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Recent News and Articles on the Keywords: breast cancer + brca1 mutations + women  Related to the article below (Last Update: 7/1/2008)

Survey Reveals Cancer Links ; In Association With the NHS North East
RedOrbit, TX -
The median survival time for BRCA1 carriers was eight years. Both genes greatly increase the risk of women developing breast cancer and are also linked to ...
Experimental Imaging System Helps Detect Breast Cancer
U.S. News & World Report, DC - Jun 26, 2008
Last year, the American Cancer Society issued recommendations that women at high risk for breast cancer (such as those with the BRCA1 or BRCA2 gene mutation ...
When you need a shoulder to lean on
Jerusalem Post, Israel - Jun 21, 2008
"I had ductal breast cancer in situ, treated with 33 radiation treatments and Tamoxifen." She was tested for BRCA mutations and found to be free of them. ...
Highlights of the Week's Men's Health News
U.S. News & World Report, DC - Jun 27, 2008
Both those gene mutations significantly increase the risk that a man's female relatives?and that he himself?will develop breast cancer. ...
A supercomputer takes on a killer
Globe and Mail, Canada - Jun 27, 2008
For example, women can now be tested for mutations in the BRCA1 and BRCA2 genes that signal a higher chance of getting breast or ovarian cancer - and some ...
Polygenic Analysis May Aid Breast Cancer Diagnosis
GenomeWeb News (subscription), NY - Jun 26, 2008
The most well-known single genes associated with high increases in breast cancer risk are BRCA1 and BRCA2. But just a quarter of inherited breast cancer can ...
Baptist hopes new breast cancer center will help women better ...
commercialappeal.com (subscription), TN - Jun 15, 2008
Only a small fraction of the estimated 900000 US women with a BRCA1 or BRCA2 gene mutation, the gene changes most associated with breast cancer, ...
Woman copes with rare breast cancer that's unresponsive to common ...
KTKA.com, KS - Jun 17, 2008
"We know that women with a family history of breast cancer who have a BRCA-1 mutation are most at risk," Olopade said. However, researchers admit they still ...

The Money Times
Thousands Marched To Make The World Breast Cancer-Free
The Money Times, India - Jun 22, 2008
Besides accounting for 15% of all breast cancer, BRCA1 and BRCA2 mutations are associated with increased risk of variety of other cancer including ovarian ...
Women of Ashkenazi Jewish ancestry to be tested for cancer gene ...
Times and Transcript, Canada - May 28, 2008
About 70 per cent of women who are BRCA1 mutation carriers will develop breast cancer by age 70 while 40 per cent will develop ovarian cancer by the same ...
Source: Google News

BRCA1 Mutations in Women Attending Clinics That Evaluate the Risk of Breast Cancer -
FJ Couch, ML DeShano, MA Blackwood, K Calzone, J … - New England Journal of Medicine, 1997 - content.nejm.org
Original Article from The New England Journal of Medicine -- BRCA1 Mutations in
Women Attending Clinics That Evaluate the Risk of Breast Cancer. ...

Germ-Line BRCA1 Mutations in Jewish and Non-Jewish Women with Early-Onset Breast Cancer -
MG FitzGerald, DJ MacDonald, M Krainer, I Hoover, … - New England Journal of Medicine, 1996 - content.nejm.org
... We sought BRCA1 mutations in women who were given a diagnosis of breast cancer at
an early age, because early onset is characteristic of a genetic ...

BRCA1 Mutations in a Population-Based Sample of Young Women with Breast Cancer -
AA Langston, KE Malone, JD Thompson, JR Daling, EA … - New England Journal of Medicine, 1996 - content.nejm.org
... in a population-based study of early-onset breast cancer to assess the spectrum
and frequency of germ-line BRCA1 mutations in young women with breast cancer. ...

Risk-Reducing Salpingo-Oophorectomy in Women With a BRCA1 or BRCA2 Mutation. -
ND Kauff, JM Satagopan, ME Robson, L Scheuer, M … - Obstetrical & Gynecological Survey, 2002 - obgynsurvey.com
... in rates of development of breast cancer and other gynecologic cancers related to
the BRCA mutation found a significantly higher proportion of women in the ...

… and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2 National … -
MC King, S Wieand, K Hale, M Lee, T Walsh, K Owens … - JAMA, 2001 - Am Med Assoc
... treatment, and if oophorectomy is performed before age 35 years and is effective
in reducing breast cancer incidence among women with BRCA1 mutations, 38 then ...

Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation -
H Meijers-Heijboer, B van Geel, WLJ van Putten, SC … - New England Journal of Medicine, 2001 - content.nejm.org
... Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1
and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1 ...

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations -
TR Rebbeck, HT Lynch, SL Neuhausen, SA Narod, L … - New England Journal of Medicine, 2002 - content.nejm.org
... Conclusions Bilateral prophylactic oophorectomy reduces the risk of coelomic epithelial
cancer and breast cancer in women with BRCA1 or BRCA2 mutations. ...

… appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women -
D Abeliovich, L Kaduri, I Lerer, N Weinberg, G … - Am J Hum Genet, 1997 - pubmedcentral.nih.gov
... Schluger A, Hampel H, Brown K, Swensen J, Neuhausen S, Skolnick M, Norton L, Goldgar
D. Germline BRCA1 185delAG mutations in Jewish women with breast cancer. ...

Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers -
TR Rebbeck, AM Levin, A Eisen, C Snyder, P Watson, … - jnci, 1999 - jnci.oxfordjournals.org
... To evaluate whether bilateral prophylactic oophorectomy alters the risk of developing
breast cancer in women who have BRCA1 mutations, we compared the ...

Survival and Tumour Characteristics of Breast-Cancer Patients with Germline Mutations of BRCA1. -
LC Verhoog, CTM Brekelmans, C Seynaeve, LMC van … - Obstetrical & Gynecological Survey, 1998 - obgynsurvey.com
... risk of breast cancer at about 50 percent by age 50 in women with a BRCA1 mutation,
but BRCA1 is a very large gene and multiple different mutations have been ...

Source: Google Scholar

Breast Cancer Survival Rates No Worse For Women With BRCA Mutations
Breast cancer patients who possess one of the so-called "breast cancer" or BRCA genetic mutations do not have a higher risk of dying than patients with no BRCA mutations, according to a detailed study by researchers at the Technion-Israel Institute of Technology and the University of Toronto. The findings are published in the July 12 issue of the New England Journal of Medicine.

Since some BRCA-related breast cancers occur earlier in life and can be resistant to common hormone treatments due to lack of hormone receptors in the tumor, researchers have wondered whether patients with the mutations might have a worse prognosis than others.
With the new study, "we can offer the reassurance that in spite of a bad profile of prognostic factors in carriers, their survival rate is actually at least as good as for noncarriers," said Technion researcher Dr. Gad Rennert.

The researchers looked at 1,545 Israeli women's survival rates 10 years after diagnosis, and found that the prognosis was similar among those with a mutation and those without. Ten years later, 33 percent of non-carriers, 33 percent BRCA1 carriers and 44 percent of BRCA2 carriers had died.

Dr. Rennert and Dr. Steven Narod, Director of the Familial Breast Cancer Research Unit of Women's College Research Institute, Toronto, and their colleagues say their findings could help women with BRCA mutations decide whether to pursue surgery or continue with vigilant screenings to lessen their chances of developing cancer.

The researchers took advantage of a unique set of medical records and tumor tissue samples from 1,545 Israeli women diagnosed with invasive breast cancer in the late 1980s. Among Jewish women of Ashkenazi descent in the study, two mutations of the BRCA1 gene and one BRCA2 mutation are especially prevalent.

However, since these women were diagnosed before the discovery of BRCA genes and received no special care as a result, the researchers were able to compare their survival rates directly to survival rates among patients without the mutations.

"The study can probably not be repeated with these advantages anywhere in the world, as Israel is the only place with such a high concentration of mutation carriers," Rennert noted.
Chemotherapy boosted the overall survival rates of patients with BRCA1 mutations, compared to survival rates among patients with no mutation. BRCA2 patients and patients with no mutation had similar survival rates, regardless of whether chemotherapy was part of their treatment.

"BRCA1 carriers seem in fact to be unusually sensitive to chemotherapy," said Narod. "These findings suggest that chemotherapy may benefit all women with a BRCA1 mutation, regardless of age or tumor size."

BRCA mutations can interfere with a cell's normal mechanisms for repairing damaged DNA, which may partially explain why chemotherapy had a different effect among BRCA1 patients, according to Rennert. Chemotherapy's attacks on cancer cells may be more effective if these cells already have problems repairing damage, he explained.

"We definitely need to further evaluate the role of specific chemotherapy agents in BRCA carriers to be able to better offer specific chemotherapies to patients," Rennert said.

The Technion-Israel Institute of Technology is Israel's leading science and technology university. Home to the country's winners of the Nobel Prize in science, it commands a worldwide reputation for its pioneering work in nanotechnology, computer science, biotechnology, water-resource management, materials engineering, aerospace and medicine. The majority of the founders and managers of Israel's high-tech companies are alumni. Based in New York City, the American Technion Society is the leading American organization supporting higher education in Israel, with 17 offices around the country.

American Technion Society
Technion-Israel Institute of Technology 55 East 59th St.
New York, NY 10022
United States
http://www.ats.org
 
 
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