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Recent News and Articles on the Keywords: folic acid + congenital malformations + folic  Related to the article below (Last Update: 5/5/2008)

Renowned UC San Diego Researcher Receives Hartwell Foundation ...
UCSD Medical Center, CA - Apr 30, 2008
Jones says that even though this study is in the very early stage, its potential is similar to that of previous studies involving folic acid. ...
Healthy tips can pave the way for those months of pregnancy
Charleston Post Courier, SC - Apr 7, 2008
Folic acid is vital to fetal development and guards against several congenital malformations. He also suggests selenium, a trace mineral crucial for proper ...
Source: Google News

Folic Acid Antagonists During Pregnancy and the Risk of Birth Defects. -
S Hern?ndez-Diaz, MM Werler, AM Walker, AA … - Obstetrical & Gynecological Survey, 2001 - obgynsurvey.com
... took multivitamin supplements containing folic acid, the risks ... up to a 6% prevalence
of major congenital malformations. ... human studies relating folate levels in ...

Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs. -
Y Biale, H Lewenthal - Eur J Obstet Gynecol Reprod Biol, 1984 - ncbi.nlm.nih.gov
Eur J Obstet Gynecol Reprod Biol. 1984 Nov;18(4):211-6. Effect of folic acid
supplementation on congenital malformations due to anticonvulsive drugs. ...

Serum folic acid levels in epileptic mothers and their relationship to congenital malformations. -
Y Ogawa, S Kaneko, K Otani, Y Fukushima - Epilepsy Res, 1991 - ncbi.nlm.nih.gov
Epilepsy Res. 1991 Jan-Feb;8(1):75-8. Click here to read Serum folic acid levels
in epileptic mothers and their relationship to congenital malformations. ...

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development -
JA Piedrahita, B Oetama, GD Bennett, J van Waes, … - Nature Genetics, 1999 - nature.com
... Therapeutic abortions with a folic acid antagonist, 4 ... MF Jr Methotrexate induced
congenital malformations with a ... Evans, HM Pteroylglutamic acid and reproduction ...

… recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and … -
M Tolarova, J Harris - Teratology, 1995 - doi.wiley.com
... in a mother could cause congenital malformations in the ... Nonetheless, prevention of
congenital anomalies seemed impossible to ... 4 mg/day of folic acid from the ...

Case-Control Study of Periconceptional Folic Acid Supplementation and Oral Clefts -
C Hayes, MM Werter, WC Willett, AA Mitchell - American Journal of Epidemiology, 1996 - Oxford Univ Press
... containing multivitamin or a folic acid supple- ment ... family history of congenital
malformations, mother's medical ... es- timation of dietary folate intake during ...

Neural Tube Defects in Relation to Use of Folic Acid Antagonists during Pregnancy. -
S Hernandez-Diaz, MM Werler, AM Walker, AA … - American Journal of Epidemiology, 2001 - pt.wkhealth.com
... JB, Seattle W. Therapeutic abortions with a folic acid antagonist, 4-
aminopteroylglutamic acid (4-amino PGA ... Methotrexate-induced congenital malformations. ...

Use of Multivitamins and Folic Acid in Early Pregnancy and Multiple Births in Sweden -
A Ericson, B Kallen, A Aberg - Twin Research and Human Genetics, 2001 - Aus Acad Press
... acid for the prevention of congenital anomalies. ... Multivitamin/folic acid supplementation
in early pregnancy reduces the ... folate intake and malformations of the ...

Effect of Reducing Interns' Weekly Work Hours on Sleep and Attentional Failures. -
SW Lockley, JW Cronin, EE Evans, BE Cade, CJ Lee, … - Obstetrical & Gynecological Survey, 2005 - obgynsurvey.com
... of periconceptional folic acid and folate fortification of certain foods, spina
bifida continues to be 1 of the most common congenital malformations, affecting ...

Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 … -
N Biotechnology, N Methods, N Conferences, D … - Nature Genetics, 1996 - nature.com
... Prenatal treatment of Cart1 homozygous mutants with folic acid suppresses the ... James,
LM Temporal trends in the prevalence of congenital malformations at birth ...

Source: Google Scholar

Adding Folic Acid To Flour Significantly Reduces Congenital Malformations
Dr. Philippe De Wals of Universite Laval's Department of Social and Preventive Medicine today publishes a study clearly indicating that the addition of folic acid to flours has led to a 46% drop in the incidence of congenital neural tube deformation (mainly anencephaly and spina bifida) in Canada. Such deformations either result in the child's death or in major health problems, including physical and learning disabilities. Dr. De Wals's work as head of a team of a dozen Canadian researchers appears today in the New England Journal of Medicine.

The neural tube is the basis of the embryo's nervous system. Poor development of the neural tube, which is sometimes due to a lack of folic acid, can result in major health problems.
Folic acid is found in green vegetables, fruit, whole grains, and meat. However, even a balanced diet won't supply enough folic acid for a pregnant mother and the child she is carrying. Before1998, Canadian medical authorities were already recommending that women in their child-bearing years consume vitamin supplements containing folic acid. "Canada decided to add folic acid to all flour produced in the country because formation of the neural tube in embryos is particularly intense during the first four weeks of pregnancy, which is before a lot of women even know they're pregnant. Since half of Canadian pregnancies are unplanned and the human body can't store folic acid, it is better to integrate folic acid into the food chain than to focus exclusively on taking vitamin supplements," stated Dr. De Wals. Health Canada still recommends taking folic acid supplements to women in their child-bearing years.

Researchers Dr. Philippe De Wals and Fassiatou Tairou of Université Laval's Faculty of Medicine compared the incidence of neural tube deformations before and after the introduction of folic acid-enriched flours for over 2 million births in Canada. Between 1993 and 1997, the incidence was 1.58 per 1,000 births. Between 2000 and 2002, the rate dropped 46% to 0.86. The biggest improvement occurred in the parts of Canada that had the highest rates of neural tube deformation before 1998-Newfoundland, Prince Edward Island, and Nova Scotia. In Québec, the drop was also pronounced, but closer to the Canadian average.

Currently, only Canada, the United States, and Chile require that folic acid be added to flour. The effectiveness of this practice, as demonstrated by Dr. De Wals's team, could encourage other countries to follow suit. Every year, approximately 200,000 cases of spina bifida and anencephaly occur worldwide. Adding folic acid to food could reduce that number by half.

Université Laval
 
 
 
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