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Recent News and Articles on the Keywords: heavy hearts + sudden death + heart  Related to the article below (Last Update: 7/8/2008)

Death Shows We Must Learn About Heart
The Ledger, FL -
He died of a sudden massive heart attack at age 52 while running in Vermont. He had no symptoms, though he regularly ran 10 miles daily. ...
Neil Young, Hop Farm Festival, Kent
Independent, UK -
There are singalongs to the acoustic country harmonies of "Oh Lonesome Me, "Heart of Gold", "Old Man" and even "The Needle and the Damage Done", ...

Chatter Shmatter
HEALTH JOURNAL
Wall Street Journal Blogs, NY - Jun 17, 2008
What lessons can we learn from Tim Russert's death? Share your thoughts. Everybody knows somebody who has had a sudden, fatal heart attack, and it's many ...
AssociatedPress
all 776 news articles »
Jamie Nesbitt: John Ware, pioneer black rancher Jamie Nesbitt
Brooks Bulletin,  Canada -
The next spring, however, saw a sudden move two miles south to higher ground when the river flooded out the family during the night. ...
Hearts are heavy without Shays in Oregon
Detroit Free Press, United States - Jun 27, 2008
At the Central Lake Invitational in early May, Joe Shay, Ryan's father, was moved to tears when the track team from Mt. Pleasant Sacred Heart arrived at the ...
Showing heart - the life-and-death kind
Globe and Mail, Canada - Jun 19, 2008
The sudden death of NBC's Meet the Press moderator Tim Russert last week, felled by a heart attack at the age of 58 at his Washington workplace, ...

The Plain Dealer - cleveland.com
Matthew McConaughey has a son; Paris Hilton has an idea for a ...
The Plain Dealer - cleveland.com, OH -
An ABC producer is crediting Tim Russert's sudden death with nudging him to the hospital before a severe heart attack could kill him. ...
Certain drugs can cause problems in heat
News-Leader.com, MO - Jul 5, 2008
As a person heats up, the heart pumps more blood to vessels, the blood circulates closer to the skin's surface and excess heat drains off into the cooler ...
Giving up alcohol could have caused drinker's death
Bucks Free Press, UK - Jun 11, 2008
He said: "One is a sudden circulatory event. A sudden drop in blood pressure to the heart but we do normally see evidence of that. ...
French students were bound, gagged and stabbed 250 times
Independent, UK - Jul 3, 2008
I love you from the bottom of my heart." Before his death, she had left messages saying how much she missed him. "Come back quickly, mon chou! ...
Source: Google News

Expression of Protein Kinase C ? in the Heart Causes Hypertrophy in Adult Mice and Sudden Death in … -
JC Bowman, SF Steinberg, T Jiang, DL Geenen, GI … - Journal of Clinical Investigation, 1997 - pubmedcentral.nih.gov
... relaxation, whereas expression in newborns caused sudden death associated with ... of
a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells ...

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated … -
M Donoghue, H Wakimoto, CT Maguire, S Acton, P … - Journal of Molecular and Cellular Cardiology, 2003 - Elsevier
... into the SalI site of the 5.5 kb mouse cardiac a-myosin heavy chain (aMHC ... 3.1.
Transgenic expression of hACE2 in the mouse heart leads to sudden death. ...

… overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death -
IN Mungrue, R Gros, X You, A Pirani, A Azad, T … - Journal of Clinical Investigation, 2002 - pubmedcentral.nih.gov
... this study the a-myosin heavy chain (a ... fact that mice that developed overt heart
failure tended ... be older animals that had avoided sudden death, suggests that ...

Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. -
AG Shaper, G Wannamethee, PW Macfarlane, M Walker - British Medical Journal, 1993 - heart.bmj.com
... blood cholesterol, smoking, social class, heavy drinking, and ... seen in those with
increased heart rate was ... a significantly increased risk of sudden cardiac death ...

Cardiac failure and sudden death in the Framingham Study. -
WB Kannel, JF Plehn, LA Cupples - Am Heart J, 1988 - ncbi.nlm.nih.gov
... alone increased the risk of sudden death fivefold. ... who also had coronary heart disease
there ... hypertension, obesity, glucose intolerance, heavy smoking, cardiac ...

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction … -
R Marchioli, F Barzi, E Bomba, C Chieffo, D Di … - Circulation, 2002 - Am Heart Assoc
... of coronary heart disease morbidity and mortality among heavy smokers: the ... Prognostic
value of heart rate variability for sudden death and major ...

Hypertrophic Cardiomyopathy Histopathological Features of Sudden Death in Cardiac Troponin T Disease -
AM Varnava, PM Elliott, C Baboonian, F Davison, MJ … - Circulation, 2001 - Am Heart Assoc
... with two distinct mutations in the beta- myosin heavy chain gene: a ... Magnitude of
left ventricular hypertrophy and risk of sudden death in hypertrophic ... Heart. . ...

Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death -
AR Marks - Journal of Molecular and Cellular Cardiology, 2001 - Elsevier
... muscle, Ca 2+ release from heavy sarcoplasmic reticulum ... role in de- termining the
heart failure phenotype ... fatal cardiac arrhythmias that lead to sudden cardiac ...

Complete heart block and sudden death in mice overexpressing calreticulin -
K Nakamura, M Robertson, G Liu, P Dickie, K … - Journal of Clinical Investigation, 2001 - pubmedcentral.nih.gov
... containing the 5.5-kb mouse cardiac a-myosin heavy chain (a ... 5d, lower recording),
there was a complete heart block followed by sudden cardiac death. ...

[PDF] The failing heart -
JA Towbin, NE Bowles - Nature, 2002 - cmbi.bjmu.edu.cn
... death is divided evenly between sudden death and pump ... protein-encoding genes actin,
-myosin heavy chain, -tropomyosin ... to that seen in the hearts of individuals ...
-

Source: Google Scholar

Sudden Cardiac Death And Heavy Hearts
Those with heavy hearts - in the literal not figurative sense - long have been known to be prone to cardiac arrest and sudden death. But many are not, and who among them is subject to serious risk is a mystery. To find clues to the puzzle, the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health has just awarded $2 million to Sumeet Chugh, M.D., director of Oregon Health & Science University's cardiac arrhythmia center in the division of cardiovascular medicine.

The condition known as left ventricular hypertrophy (LVH), or a thickening and swelling of the heart wall, can be found, by some estimates, in up to 20 percent of the middle-aged population with heart disease in the United States. Some $3 billion to $5 billion worth of pocket defibrillators are being implanted under Medicare guidelines annually to jump start hearts at risk of a cardiac arrest.
Yet research studies show that only one out of 15 of the devices ever will be needed to save a life, which is why pinpointing who among those with LVH is at greatest risk of cardiac arrest is a multibillion dollar priority.

The five-year NHLBI grant will provide funds for Chugh, the principal investigator and an associate professor in the cardiovascular division of the OHSU School of Medicine, along with his team of clinicians, scientists and researchers, to continue the landmark Oregon Sudden Unexpected Death Study (Ore-SUDS), which Chugh initiated five years ago. The Ore-SUDS study is a community-based effort that includes a partnership with the emergency medical response system (Jonathan Jui, M.D., professor of emergency medicine, OHSU School of Medicine) the state medical examiner network (Karen Gunson, M.D.) and 16 area hospitals, thus enabling a systematic study of all sudden cardiac arrests that occur in the Portland metropolitan area. Several findings have been published earlier including the only U.S. data on the current burden of cardiac arrest obtained in a prospective manner. A separate collaborative effort with the Donald W. Reynolds Cardiovascular Clinical Research Center at Johns Hopkins University Reynolds Cardiovascular Center (Eduardo Marban, M.D., Ph.D., director) focusing on the link between cardiac arrest and the human genome is also ongoing.

"We found in analyzing the Ore-SUDS data," said Chugh, "that if you have left ventricular hypertrophy in Multnomah County your risk of cardiac arrest is increased at least twofold and, in combination with specific other conditions such as a weakened pumping ability of the heart muscle, the risk can be much higher. But that doesn't mean everybody with the condition is at risk. Left ventricular hypertrophy is associated with high blood pressure, and lots of people have high blood pressure but not all of them are prone to cardiac arrest.

Chugh reported in the Journal of the American College of Cardiology in March that less than a third of the sudden cardiac deaths where left ventricular dysfunction had previously been evaluated in the Ore-SUDS data had dysfunction that was severe enough to warrant implantation of a cardioverter-defibrillator. "These findings support the aggressive development of alternative screening methods to enhance identification of patients at risk," Chugh wrote.
Speaking about his team's plans going forward, Chugh said: "We want to figure out what will significantly improve our ability to predict cardiac arrest," Chugh continued. "Our ultimate aim is to nip it in the bud, which for patients that will suffer cardiac arrest means averting disaster before it happens. The evaluation of information that we have gathered in Ore-SUDS combined with what we learn at the bedside from patients together with bench research we are doing on the molecular mechanisms involved represent a comprehensive approach that we think hold great promise of solving the puzzle. If we can predict who the high risk patient with left ventricular hypertrophy is, that is likely to have huge significance for our patients."

According to the American Heart Association, about 250,000 Americans succumb each year to sudden cardiac death, which is defined as death within one hour of the time a person displays symptoms such as chest pain or difficult breathing. About half have shown no prior evidence of heart disease and about 40 percent are under age 65. In most cases, cardiac arrest results from arrhythmia, or abnormal heart rhythm. The survival rate ranges between 5 percent and 10 percent despite improvement in emergency medical services and widespread training in application of CPR.

Source: Harry Lenhart
Oregon Health & Science University
 
 
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