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Recent News and Articles on the Keywords: drug-resistant superbugs + superbug + drug-resistant  Related to the article below (Last Update: 5/19/2008)

Feeling fat? Brew a cup of green tea, recommends KU prof
Daily Times, Pakistan - May 15, 2008
Green tea also made 20% of drug-resistant bacteria susceptible to one of the cephalosporin antibiotics. These are important antibiotics that new drug ...
Steno superbug has been here for over a decade
Belfast Telegraph, United Kingdom - May 9, 2008
Experts in England this week added the microbe to what they described as an " ever-increasing list of antibiotic-resistant hospital superbugs" which also ...

BBC News
Patients warned of new superbug
ITV.com, UK - May 7, 2008
Hospital patients are being warned about a new drug resistant superbug which is sweeping through the wards. The bug known as Steno, clings to catheters and ...
New superbug threat to hospitals The Press Association
The new superbug ..are you at risk? Mirror.co.uk
A drug-resistant microbe that clings to catheters and ventilation ... Hospital Healthcare Europe
all 110 news articles »
Steno 'Superbug' Genome Shows Extreme Drug Resistance
Forbes, NY - May 9, 2008
FRIDAY, May 9 (HealthDay News) British research into Steno, one the most recent "superbugs" to claim lives, reveals that the bacterium has an incredible ...
Shining light on dirty subject Invention could solve resistant ...
Foster's Daily Democrat, NH - May 4, 2008
More importantly, it could help health care professionals tackle the increasing scourge of drug-resistant infections, saving billions of dollars and ...
Source: Google News

Patient perceptions of MRSA -
SMA Hamour, AO'Bichere, JL Peters, PJ McDonald - Annals of The Royal College of Surgeons of England, 2003 - ingentaconnect.com
... the search terms MRSA, surgery, superbug, public awareness ... had heard of either superbugs
or MRSA ... Drug-resistant nosocomial infections are an increasing problem. ...

'Superbugs': new antibacterials in the pipeline
K Bush, M Macielag, J Clancy - emd, 2000 - Expert Opinion
... ?Superbug? has become a byword for the anti ... agents effective against multi-drug
resistant Gram-positive ... activity against Gram-positive Superbugs are known ...

CQ R esearcher -
F Superbugs - CQ Researcher, 2007 - capna.com
... what doctors belatedly identified as the MRSA superbug. ... of all staph infections were
drug resistant in 2004. ... 688 How Superbugs Develop Resistance Quickly Speed ...
-

[PDF] THE SUPER BUGS
VRE MRSA, V VISA - camlt.org
... 2. Define the ?super bugs? (resistant gram positive ... Fortunately, this super bug was
susceptible to ... infection with a drug-resistant Staphylococcus aureus. ...

Colony Collapse Disorder May Affect Complementary and Alternative Medicine
CME Medscape, M Connect, C Care, G Surgery, M … - medscape.com
... Add a sprinkling of antibiotics and drug-resistant strains emerge -- the superbugs
that are ... respond to other drugs, was free of this superbug within 48 ...

MICROBIOLOGY: Deconstructing Vancomycin -
C Walsh - Science, 1999 - sciencemag.org
... raise the specter of the worst kind of antibiotic-resistant superbug (3). The ... all
may not be lost in the fight against multi-drug-resistant superbugs, at least ...

ANTIBIOTIC RESISTANCE: Superbugs on the Hoof? -
D Ferber - Science, 2000 - sciencemag.org
... person to succumb to a superbug resistant to ... Laboratory in Copenhagen traced the
drug-resistant strain of ... practice can spawn new superbugs, agencies worldwide ...

Resistant'Superbugs' Create Need for Novel Antibiotics -
HB Become?Superbugs - medscape.com
... MRSA) is probably the best known superbug. ... of 7. Next Page: Which Bacteria Are Called
?Superbugs'? ... Fact sheet: Drug-resistant streptococcus pneumoniae disease ...
-

The Staphylococcus aureus ?superbug.? -
TJ Foster - J Clin Invest, 2004 - pubmedcentral.nih.gov
... The Staphylococcus aureus ?superbug?. ... particularly virulent genotypes, or ?superbugs.?
A study ... novel hypervirulent or epidemic drug-resistant S. aureus ...

Miracle Drugs vs. Superbugs. -
T Nordenberg - FDA Consumer, 1998 - questia.com
... Superbugs. ... trend, most people aren't likely to encounter a "superbug" that can ... These
surviving genes can multiply quickly, creating drug-resistant strains. ...

Source: Google Scholar

Disrupt An Enzyme, Destroy Drug-Resistant Superbugs

New method prevents the transfer of antibiotic resistance (killing the stronger bacteria in the process)
By Nikhil Swaminathan
In the continuing battle to counter growing antibiotic resistance, a new finding may help keep our current arsenal of antibacterial agents from having to be scrapped and replaced by an as yet unrealized new infection-fighting therapy.

By targeting an enzyme that bacteria use to swap genetic material, researchers at the University of North Carolina at Chapel Hill, have stopped the microbes' ability to spread, among other advantageous mutations, resistance to antibiotics.

"It turns out bacteria are very social," says Matthew Redinbo, a U.N.C. associate professor of chemistry, biochemistry and biophysics. "They pass genes between one another that keep one another intact." He adds that this transfer can occur between bacteria of either the same or different species.
But as Redinbo and colleagues report in this week's Proceedings of the National Academy of Sciences USA, if the mechanism for this genetic transfer is blocked, the selective death of the antibiotic-resistant members of a bacterial culture is somehow triggered.

"We designed the whole thing to stop [the] transfer of genes," Redinbo says. "The biggest surprise was that stopping transfer also killed the resistant bacteria." He notes that his group does not know exactly how antibiotic resistant bacteria are killed off, but that interfering with the way a cell manipulates its DNA often causes cell death.

The DNA process disrupted by the U.N.C. team is called conjugation, which occurs when two bacteria sidle up to one another and punch holes in each of their outer membranes, allowing one microbe to shoot a single strand of DNA into the other. This mechanism is achieved via an enzyme called DNA relaxase, they noted, which acts as a gatekeeper, both initiating and ending the movement of the genetic material between the bacteria.

Scott Lujan, a graduate student in Redinbo's lab, made a key discovery: The DNA relaxase molecule has two "catalytic weapons" that allow it to perform its duties of breaking apart DNA strands. (Most other enzymes only have one; DNA relaxase needs two in order to contact the strands of DNA in the donating bacterial cell.) This finding alerted the team that in order for a chemical to disrupt DNA relaxase, it would need to block both catalytic sites on the enzyme.

They settled on bisphosphonates, which have already been approved by the Food and Drug Administration (FDA) to battle osteoporosis, a bone-thinning disease. Two drugs, clodronate and etidronate (aka Didronel), blocked DNA relaxase and, as a result, conjugation. An unexpected result of this disruption, however, was the fact that the antibiotic-resistant Escherichia coli bacteria that were trying to pass their genes along, actually died when their DNA relaxase was shielded.

Redinbo says that his group is studying mice carrying infections in their gastrointestinal tract, skin and muscle tissue to see if the new mechanism for disrupting DNA relaxase is effective in the mammalian body. But he adds that "a clinician could use these approved drugs right away if faced with a resistant bacteria."
"New method prevents the transfer of antibiotic resistance (killing the stronger bacteria in the process)"
By Nikhil Swaminathan
Scientific American
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