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Recent News and Articles on the Keywords: older women + study confirmed + hrt  Related to the article below (Last Update: 5/12/2008)

Hormone Therapy Linked to Stroke Regardless of Timing
MedPage Today, NJ - Apr 28, 2008
The results, the authors said, were virtually identical to those seen in the Women's Health Initiative study, and Wyeth, the maker of Premarin (conjugated ...
Source: Google News

Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women The Cache County Study -
PP Zandi, MC Carlson, BL Plassman, KA Welsh-Bohmer … - JAMA, 2002 - Am Med Assoc
... logical conclusion, our findings suggest that if women were to ... of AD over that of
men in late old age might ... A new finding in this study is an apparent limited ...

HRT preserves increases in bone mineral density and reductions in body fat after a supervised … -
WM Kohrt, AA Ehsani, SJ Birge - Journal of Applied Physiology, 1998 - Am Physiological Soc
... The aims of this study were to confirm our previous ... therapy (HRT) augments
exercise-induced increases in bone mineral density (BMD) in older women and to ...

Hormone Replacement Therapy, Inflammation, and Hemostasis in Elderly Women -
M Cushman, EN Meilahn, BM Psaty, LH Kuller, AS … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1999 - Am Heart Assoc
... on hemostatic balance, at doses usually used by older women. ... light of recent reports,
8 13 requires further study. ... the markers need to be confirmed in ongoing ...

Hormone replacement therapy and reduced cognitive decline in older women The Cache County Study -
MC Carlson, PP Zandi, BL Plassman, JT Tschanz, KA … - Neurology, 2001 - AAN Enterprises
... in modified MMSE score over the study interval ... onto lifetime use of HRT in all older
women who were ... These cross-sectional associations are confirmed in the model ...

… of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study -
M Komulainen, MT Tuppurainen, H Kr?ger, AM … - Osteoporosis International, 1997 - Springer
... these studies were designed for much older people (mean ... the results of our study
confirm the beneficial ... in non-osteoporotic early postmenopausal women and does ...

The effect of hormone replacement therapy on the sensitivity of screening mammograms -
JC Litherland, S Stallard, D Hole, C Cordiner - Clinical Radiology, 1999 - Elsevier
... times the risk of the lowest group (older women not taking ... This is likely to be because
women in the ... However, our study may still underestimate the effect of ...

Mortality associated with hormone replacement therapy in younger and older women -
SR Salpeter, JME Walsh, E Greyber, TM Ormiston, EE … - Journal of General Internal Medicine, 2004 - Springer
... Inclusion: Postmenopausal women at least 45 years old with elevated ... Study (Reference #) ...
Inclusion: Postmenopausal women with 3 or more confirmed urinary tract ...

Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled … -
MR Blackman, JD Sorkin, T Munzer, MF Bellantoni, J … - JAMA: The Journal of the American Medical Association, 2002 - jama.waldenu.edu
... improves body composition, 2 but studies have not ... prescription of GH for healthy
older persons to ... HRT) in healthy postmenopausal women decreases abdominal ...
-

… therapy: Review, update, and remaining questions after the women?s health initiative study -
JC Stevenson - Current Osteoporosis Reports, 2004 - Springer
... but is inappropriately high for women 20 years older. ... Ran- domized clinical trials
start women in their 60s ... is more promising, and further studies are awaited. ...

Hormone Replacement Therapy and Prevention of Nonvertebral Fractures A Meta-analysis of Randomized … -
DJ Torgerson, SEM Bell-Syer - JAMA, 2001 - Am Med Assoc
... effective to offer HRT for fracture prevention in older women. ... 3 trials were undertaken
among women with low ... HERS study dominates the longer studies and this ...

Source: Google Scholar

Study Confirms No HRT Benefit For Older Women
New evidence published on bmj.com confirms that hormone replacement therapy (HRT) should not be prescribed to older women who are many years past menopause to help prevent chronic conditions such as heart disease.

But the authors support the view that HRT is a safe short term treatment for younger women in early menopause to relieve symptoms and improve quality of life.

In 2002, the Women's Health Initiative (WHI) trial found that postmenopausal women taking HRT had more heart attacks and strokes than non-HRT users. The trial was halted early and millions of women around the world stopped taking HRT. But scientists now believe that these risks may only apply to older women who do not normally use HRT.
In 1999, another trial (WISDOM) began to assess the long-term risks and benefits of HRT after the menopause. This trial was also stopped after the first WHI results appeared, but the WISDOM findings, published today, make an important contribution to the body of knowledge about HRT when it is initiated in older postmenopausal women.

The WISDOM team identified 5,692 healthy women registered at general practices in the UK, Australia and New Zealand with an average age of 63 years and 15 years after the menopause.

The women who had not had a hysterectomy were split at random into two groups. One was given a daily dose of combined hormone therapy (oestrogen and progestogen) and the other group was given a placebo pill. Women who had had a hysterectomy were split between combined hormone treatment, oestrogen only and a placebo.

All women were monitored for an average of 12 months and main outcomes such as cardiovascular disease, osteoporotic fractures, breast cancer and deaths, were recorded.

There was a significant increase in the number of major cardiovascular events (angina, heart attack or sudden coronary death) and blood clots (venous thromboembolisms) in the combined hormone therapy group compared to the placebo group. However, rates for cerebrovascular disease, breast or other cancers, fractures and overall deaths were not significantly different in these two groups.

This study confirms an early increase in thromboembolic and cardiovascular risk in older women starting hormone replacement therapy many years after the menopause, say the authors.

It shows that there is no overall disease prevention benefit, and some potential risk, for women who start hormone replacement therapy many years after menopause.
The results are also consistent with the early findings of the WHI and other trials, and support the conclusion that combined oestrogen and progestogen therapy should not be initiated to prevent cardiovascular disease in older postmenopausal women.

However, the authors stress that these results cannot necessarily be applied to younger menopausal women starting hormone replacement therapy to relieve symptoms such as hot flushes and night sweats. For these women, recent studies suggest there may be cardiovascular benefits of taking HRT around the time of menopause. The authors say that more research is needed to assess conclusively the long term benefits and risks among these women.

Those helping women make choices about treatment should consider both the results and limitations of the WHI and WISDOM trials, particularly those women who may be influenced by the timing of initiation of hormone replacement therapy, they conclude.

In an accompanying editorial, Dr Helen Roberts at the University of Auckland says that this study does not change current advice to postmenopausal women. Healthy women in early menopause are unlikely to face substantially increased risks when using hormones for a few years, she writes. However, long term use of hormone replacement therapy to prevent chronic disease is no longer recommended as the available randomised evidence shows that the negative outcomes outweigh the positive benefits.

"Women's International Study of long Duration Oestrogen after Menopause (WISDOM): a multi-centre randomised controlled trial of hormone replacement therapy in postmenopausal women - Main Morbidities"
BMJ Online First

"Editorial: Hormone replacement therapy comes full circle"
BMJ Online First

http://www.bmj.com
 
 
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