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Recent News and Articles on the Keywords: acute myeloid + more lethal + leukemia  Related to the article below (Last Update: 5/5/2008)

Genetic Changes May Dictate Course of Acute Myeloid Leukemia
U.S. News & World Report, DC - Apr 30, 2008
By Amanda Gardner WEDNESDAY, April 30 (HealthDay News) -- Breakthroughs in understanding the extremely fine genetic underpinnings of acute myeloid leukemia ...
Genetic Differences Associated with Outcomes in Acute Myeloid Leukemia
Cancer Consultants, ID - May 1, 2008
It appears that different genetic mutations (alterations) affect outcomes among patients with acute myeloid leukemia. These results were recently published ...
Genetic Variants, MicroRNA Linked to Acute Myeloid Leukemia Outcomes
GenomeWeb News (subscription), NY - May 1, 2008
Acute myeloid leukemia or AML is a cancer of white-blood cell, red-blood cell, or platelet-making cell precursors. It typically affects older adults, ...
Mutations and Treatment Outcome in Cytogenetically Normal Acute ...
New England Journal of Medicine (subscription), MA - Apr 30, 2008
... MD, for the German?Austrian Acute Myeloid Leukemia Study Group by L?wenberg, B. Background Mutations occur in several genes in cytogenetically normal ...
MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia
New England Journal of Medicine (subscription), MA - Apr 30, 2008
However, little is known about the role of microRNAs in acute myeloid leukemia (AML). Methods Using microRNA expression profiling, we studied samples of ...
Studies help predict relapse in acute leukemia
Reuters India, India - Apr 30, 2008
Each method only covers a fraction of patients with acute myeloid leukemia, or AML, the researchers caution in the New England Journal of Medicine. ...
9-year-old Wis. girl faces third bout with cancer
USA Today - Apr 21, 2008
Emily Miller was diagnosed with acute lymphocytic leukemia in 2002, T-cell lymphoma in 2007 and then acute myeloid leukemia this past week. ...
National Marrow Donor Program?s ?Thanks Mom? Campaign
MyFox Saint Louis, MO - May 2, 2008
By Bonita Cornute Seventeen year old Deshay Woods? life changed dramatically two years ago when she was diagnosed with acute myeloid leukemia. ...
Good news for leukemia survivors
Minnesota Public Radio, MN - May 2, 2008
More than 90 percent of children who survive acute myeloid leukemia for five years or longer are still alive 20 years later. That is according to a new ...
(Blood Cancers, Blood Disorders)
Canada.com, Canada - Apr 29, 2008
Acute myeloid leukemia (AML) causes uncontrolled production and buildup of cells called myeloblasts. This interferes with the levels of functioning red ...
Source: Google News

… cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 … -
D Grimwade, H Walker, G Harrison, F Oliver, S … - Blood, 2001 - bloodjournal.hematologylibrary.org
... Acute myeloid leukemia (AML) in older adults carries a poor prognosis, and the optimum ...
55 years or older, 7%), while complex abnormalities were more common (6 ...

[PDF] The molecular biology of chronic myeloid leukemia -
MW Deininger, JM Goldman, JV Melo? - Blood, 2000 - bloodjournal.hematologylibrary.org
... Note that this is a simplified diagram and that many more associations between
Bcr-Abl and signaling proteins have been reported. ... CHRONIC MYELOID LEUKEMIA 3345 ...
-

Vaccines with interleukin-12-transduced acute myeloid leukemia cells elicit very potent therapeutic … -
K Dunussi-Joannopoulos, K Runyon, J Erickson, RG … - Blood, 1999 - ncbi.nlm.nih.gov
... properties of IL-12 in acute myeloid leukemia (AML) have ... but is incapable of rescuing
mice from lethal leukemia. ... wild-type AML cells and, more importantly, can ...

Stem Cell Transplantation for Secondary Acute Myeloid Leukemia: Evaluation of Transplantation as … -
JE Anderson, TA Gooley, G Schoch, C Anasetti, WI … - Blood, 1997 - bloodjournal.hematologylibrary.org
... prevent or detect early such lethal complications are ... myelodysplasia (MDS) and secondary
acute myeloid leukemia (sAML) following MDS of more than 6 ...

Management of Acute Myeloid Leukemia in Elderly Patients -
W Hiddemann, W Kern, C Schoch, C Fonatsch, A … - Journal of Clinical Oncology, 1999 - jcojournal.org
... ACUTE MYELOID LEUKEMIA (AML) occurs predominantly in adults, and ... patients, the strategy
of more intensive treatment ... The majority of lethal events emerge from ...

… allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic … -
R Or, MY Shapira, I Resnick, A Amar, A Ackerstein, … - Blood, 2003 - bloodjournal.hematologylibrary.org
... that may mediate more potent antitumor ... transplantation for patients with chronic
myeloid leukemia. ... and Marrow Transplantation Working Party Chronic Leukemia. ...

… antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells -
D Bonnet, EH Warren, PD Greenberg, JE Dick, SR … - Proceedings of the National Academy of Sciences, 1999 - National Acad Sciences
... the engraftment of human acute myeloid leukemia cells in ... of patients with advanced
leukemia at the ... More effective immunotherapy will require the identification ...

The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score -
O Legrand, JY Perrot, M Baudard, A Cordier, R … - Blood, 2000 - bloodjournal.hematologylibrary.org
... patients who exhibited high lethal concentration of ... Interestingly, more of these
markers (CD10, CDw65 ... for the classification of acute myeloid leukemia: a report ...

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in … -
E Passegu?, W Jochum, M Schorpp-Kistner, U M?hle- … - Cell, 2001 - Elsevier
... from junB -/- ES cells contained more cells carrying ... since its absence results
in a myeloid leukemia. ... to the development of acute myeloid leukemia ( [35]). ...

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia -
D Traver, K Akashi, IL Weissman, E Lagasse - Immunity, 1998 - actxdownload.immunity.com
... lpr mice lacking T cells developed lethal B cell ... MDS patients in transition to more
advanced disease ... is important in the etiology of acute myeloid leukemia. ...

Source: Google Scholar

Activity Of Gene Points To More Lethal Subtype Of Acute Myeloid Leukemia
A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy.

The gene, called ERG (for ETS-related gene), has also been linked to chronic leukemia and to breast and prostate cancer.

The findings apply to acute myeloid leukemia (AML) patients with leukemia cells that have normal-looking chromosomes, a feature that occurs in about half of AML patients.
Among these patients, those with leukemia cells showing high ERG activity are almost six times more likely to relapse or die within five years than are patients with low ERG expression following standard therapy.

The Cancer and Leukemia Group B study was initiated by researchers at the Ohio State University Comprehensive Cancer Center, and their findings were published online in the Journal of Clinical Oncology.

"Our study shows that high ERG activity predicts a poor prognosis in these patients, even when other molecular markers are taken into consideration," says first author Guido Marcucci, associate professor of internal medicine and an AML specialist at Ohio State's James Cancer Hospital and Solove Research Institute.

"The findings mean that these patients require a stem-cell transplant or other aggressive therapy, and that patients with low ERG activity can be treated using standard therapy."

The research confirms a 2005 study led by the same Ohio State researchers in a completely independent set of patients, Marcucci says.

"Both studies together further refine the molecular classification of AML in this group of patients and should help us improve treatment outcomes," says principal investigator Clara D. Bloomfield, professor of internal medicine, and an internationally recognized specialist in AML.

About 13,400 new cases of AML are expected this year, and a little more than half will have leukemia cells with normal-looking chromosomes. The rest will have chromosomes that show distinctive damage. In these patients, the type of damage helps doctors determine the best therapy and an individual's prognosis.
In 2005, Bloomfield, Marcucci and colleagues were the first to show that high ERG levels predicted a poor response to therapy in patients whose cancer cells have normal-looking chromosomes.

The present study was designed to verify that finding in a separate group of 76 AML patients under 60 years of age. It also took into consideration other genetic markers that signal whether the disease will respond well or poorly to standard therapy.

"We showed very similar results in this completely separate group of patients," Marcucci says. "After two years, only 29 percent of patients with high ERG were disease-free and alive versus 53 percent of patients with low ERG activity."



Funding from the National Cancer Institute and The Coleman Leukemia Research Foundation supported this research.

Source: Darrell E. Ward
Ohio State University
 
 
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