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Recent News and Articles on the Keywords: you have + keyword you + search  Related to the article below (Last Update: 5/12/2008)


eFluxMedia
Not-Just-A-Search-Engine Powerset Launches Beta
BusinessWeek -
What you notice immediately when searching on something, whether it?s in the form of a question or the usual keyword combinations, is that Powerset?s engine ...
Powerset Unveils Test Version of Google-killer ABC News
Powerset Launches Showcase For User Search Experience Washington Post
Powerset shows semantic search solution ZDNet Blogs
TechNewsWorld - RedOrbit
all 133 news articles »  GOOG - MSFT

ZDNet Asia
Helping firms occupy more 'Yellow Pages'
ZDNet Asia, Asia - 34 minutes ago
When you register a domain you have to register many multiples of it to make sure that other people don't [squat], and that's the problem. ...
Relevancy is What Matters in SEM
Promotion World (press release), CA -
Keywords are just the tip of the search query iceberg: Advertise the keyword ?bicycle? on broad match and you could very well serve for searches on the ...
Making the most of being a certified disadvantaged firm
Los Angeles Times, CA -
Answer: There are professionals who do nothing but "optimize" websites for prominent search engine placement. If you can't afford one, here are some tips ...
SherpaBlog: 5 Ways to Improve Blog Results Today: How to Engage ...
MarketingSherpa.com (subscription), RI - May 11, 2008
While it?s fine to see how many visitors you get, the most useful report is actually the keyword analysis report. There, you?ll find a list of the terms ...
Good Old-Fashioned Link Building
ClickZ News, NY - May 11, 2008
You search for potential linking partners, approach them and ask for a link (and often you provide one in return). I refer to this approach as a "direct" ...
Search Engine News, An In-Depth Look At Google's Tools & The ...
Search Engine Land, CT - May 9, 2008
This week, there was an update of the Keyword Tool. "You may have noticed that we made a change the traffic estimates data in the Keyword Tool. ...GOOG
Microsoft IM Blocking YouTube Links
Slashdot - May 10, 2008
When you have a URL filtering system, somebody's bound to screw up and do something stupid. How would blocking youtube drive traffic to MSN TV? by Sibko ...
Opinion ? You have to optimise to evolve
InternetRetailing.net, UK - May 8, 2008
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DEP Secretary Reminds Pennsylvanians to Stay Out of Mines, Quarries
PR Newswire (press release), NY -
When you venture into these sites, you put your life and the lives of emergency personnel who conduct the search and rescue operations at risk. ...
Source: Google News

[CITATION] Inc
C Technology

Statistical analysis of cointegration vectors
S Johansen - Journal of Economic Dynamics and Control, 1988 - ideas.repec.org
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Measuring the efficiency of decision making units -
A Charnes, WW Cooper, E Rhodes - European Journal of Operational Research, 1978 - ideas.repec.org
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The Brazilian Cerrado Vegetation and Threats to its Biodiversity -
JA RATTER, JF RIBEIRO, S BRIDGEWATER - Annals of Botany, 1997 - Annals Botany Co
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The relationship between return and market value of common stocks
RW Banz - Journal of Financial Economics, 1981 - ideas.repec.org
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In search of a useful theory of innovation -
RR Nelson, SG Winter - Research Policy, 1977 - ideas.repec.org
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Pulmonary complications of bone marrow transplantation -
AO Soubani, KB Miller, PM Hassoun - Chest - Am Coll Chest Phys
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[PDF] Encyclopaedia Britannica -
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Staggered Prices in a Utility-Maximizing Framework
G Calvo - Journal of Monetary Economics, 1983 - ideas.repec.org
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Management Ownership and Market Valuation: An Empirical Analysis
R Morck, A Shleifer, R Vishny - Journal of Financial Economics, 1988 - ideas.repec.org
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Source: Google Scholar

Importance Of Neutral Genetic Drift As Opposed to Natural Evolution

 
Johns Hopkins researchers have added to the growing mound of evidence that many of the genetic bits and pieces that drive evolutionary changes do not confer any advantages or disadvantages to humans or other animals.

"For a long time, the basic belief of evolution was that all random genetic changes that manage to stick around have some selective advantage," says Nicholas Katsanis, Ph.D., Associate Professor at Hopkins' Institute of Genetic Medicine. "But our work adds to the case that frequently, we are what we are largely due to random changes that are completely neutral."
"I am not at all discounting the role of natural selection, the persistence of genetic changes that confer some advantage," Katsanis adds, "because it has been instrumental. What this study does is to reinforce and highlight the equal, and in some cases greater, importance of neutral genetic drift."

Describing their contributions to genetic drift online in PLoS Genetics, Katsanis says the Hopkins experiments demonstrate that one of the major architectural markers of the human genome, DNA repeat elements that make up over 40 percent of our genome, rose to prominence without offering any benefits to the organism it inhabits. Repeat elements are fragments of DNA containing the same repetitive sequence of chemical base pairs several hundred times.

Katsanis and his team first stumbled onto one type of repeat element while looking at genes associated with Bardet Biedl syndrome, a rare disorder of substantial interest to the lab. While hunting for new genes, they found portions of DNA that had been copied from the mitochondria, the energy-making apparatus of human cells that has its own small genome. These mitochondrial sequences are known as numts.

When they expanded their study across the whole human genome, they found more than 1200 such pieces of mitochondrial DNA of various lengths embedded into chromosomes. While chimps have a comparable number, mice and rats only have around 600 numts. Since they increase in frequency as species advance, it suggested there was some evolutionary purpose to keeping them around.

Strikingly, however, none of these numts contained the blueprint (an actual gene) to make a protein that does anything, nor did they seem to control the function of any nearby genes. "At best, it seems numts are a neutral part of our genome," says Katsanis. "If anything, they may be mildly negative since long repeat sequences can be unstable or get inserted inside genes and disrupt them."

The researchers believe they have uncovered a possible reason why these potentially damaging but mostly neutral bits of DNA accumulate over time by comparing the sequences of human numts with those in different animals. How closely the different species' sequences match can provide an estimate of when that particular sequence got inserted into the ancestor of the human genome.
Their calculations revealed that most numts became embedded in our genome over a 10-million-year period centered roughly 54 million years ago -- right around the time when the first primates emerged. "When new species emerge, their numbers and therefore their genetic differences are very small," Katsanis notes. "This creates a genetic bottleneck during which any changes in the genome will either get eliminated quickly or spread to the whole population quickly."

Katsanis proposes that numts, being "neutral," were generally at low levels in ancient mammals, but during the primate emergence 54 million years ago, they accumulated and spread through the small early primate populations precisely because they were not detrimental enough to be eliminated. Then, as these populations expanded, numts reached stable but higher frequencies.



The research was funded by the National Institute of Child Health and Human Development, the National Institute of Diabetes, Digestive and Kidney Disorders, and the National Institute of Neurological Disorders and Stroke

Authors on the paper are Adrian Gherman, Peter Chen, Tanya Teslovich, Carl Kashuk, Aravinda Chakravarti, David Cutler and Katsanis of Johns Hopkins, and Pawel Stankiewicz, Marjorie Withers and James Lupski of Baylor College of Medicine

On the Web:
http://katsanis.igm.jhmi.edu/index.shtmlhttp://katsanis.igm.jhmi.edu/index.shtml
http://genetics.plosjournals.org/perlserv/?request=index-html&issn=1553-7404

Source: Nick Zagorski
Johns Hopkins Medical Institutions
 
 
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