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Recent News and Articles on the Keywords: muscle wasting + news + muscle  Related to the article below (Last Update: 5/12/2008)

Viagra offers muscular dystrophy heart hope
Telegraph.co.uk, United Kingdom -
Muscular dystrophy comes in at least 20 forms - with Duchenne being the most common - and causes muscle wasting, progressive paralysis and eventually death ...
Viagra keeps ailing hearts pumping New Scientist (subscription)
Viagra 'may help MD patients' The Press Association
Viagra may help heart in muscular dystrophy: study Reuters
WebMD
all 27 news articles »
Training Method Uses Shorter Workouts, Multiple Muscle Groups
NewsNet5.com, OH -
Sleek machine engineered to make working your individual muscle groups a little easier have been standards in the fitness industry for decades. ...
GTx, Inc. Reports First Quarter 2008 Financial Results
WELT ONLINE, Germany -
The Merck-GTx SARM clinical development program is currently pursuing sarcopenia and cancer cachexia (muscle wasting). Merck and GTx are conducting several ...GTXI

UNR NevadaNews
Professor receives grant to study muscular dystrophy
UNR NevadaNews, NV -
Loss of dystrophin in DMD patients leads to progressive muscle wasting. ?Using state-of-the-art transgenic mouse technology, we have previously demonstrated ...
GTx ups losses for 2008
Bizjournals.com, NC -
... small molecules that selectively target hormone pathways to treat cancer, osteoporosis and bone loss, muscle wasting and other serious medical conditions.GTXI
Cytokinetics Announces Selection of Development Compound That ...
CNNMoney.com - Apr 17, 2008
In the contexts of aging, muscle wasting syndromes and various neuromuscular diseases, treatment options are quite limited and unmet clinical needs are ...CYTK
Golf Tournament to Benefit ALS Research at UAMS
ArkansasSports360.com, AR -
ALS destroys cells that control voluntary muscles, which leads to severe muscle wasting and paralysis. Death typically results within three to five years of ...
Neuropathy afflicts millions
DetNews.com, MI - May 11, 2008
Disruption of those nerves leads to loss of muscle strength and muscle wasting. Foot drop is a consequence of motor-nerve neuropathy. ...
GTx Appoints Kenneth S. Robinson, MD to the Board of Directors
FOXBusiness - May 6, 2008
... molecules that selectively target hormone pathways to treat cancer, osteoporosis and bone loss, muscle wasting and other serious medical conditions. ...GTXI
Researchers Discover Molecular Basis Of A Form Of Muscular Dystrophy
Science Daily (press release) - Apr 30, 2008
By targeting the cellular and molecular mechanisms responsible for creating this protein, scientists could develop new drugs to stop muscle wasting from ...
Source: Google News

Muscle wasting in emphysema -
WL Morrison, JNA Gibson, C Scrimgeour, MJ Rennie - Clin Sci, 1988 - cs.portlandpress.com
Clinical Science (1988) 75, (415?420) (Printed in Great Britain). Muscle wasting
in emphysema. Morrison WL, Gibson JN, Scrimgeour C, Rennie MJ. ...

NF-kappa B-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia -
DC Guttridge, MW Mayo, LV Madrid, CY Wang, AS … - Science, 2000 - sciencemag.org
... factor nuclear factor kappa B (NF- B) is activated by the cytokine tumor necrosis
factor (TNF), a mediator of skeletal muscle wasting in cachexia. ...

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy -
SC Bodine, E Latres, S Baumhueter, VKM Lai, L … - Science's STKE, 2001 - stke.sciencemag.org
... whether muscle atrophy caused by disparate perturbations is controlled by a common
signaling pathway or whether distinct pathways can lead to muscle wasting. ...

Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient … -
JA Rafael, JM Tinsley, AC Potter, AE Deconinck, KE … - Nat Genet, 1998 - nature.com
... Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease usually
resulting in death of patients by their early twenties 1 . In contrast, mice ...

Myofibrillar protein catabolic rates in cirrhotic patients with and without muscle wasting -
M Zoli, G Marchesini, C Dondi, GP Bianchi, E Pisi - Clin Sci, 1982 - cs.portlandpress.com
... Myofibrillar protein catabolic rates in cirrhotic patients with and without muscle
wasting. Zoli M, Marchesini G, Dondi C, Bianchi GP, Pisi E. ...

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle -
D Yaffe, O Saxel - Nature, 1977 - nature.com
... are a group of hereditary disorders manifested by a progressive wasting of the ... the
composition of which might differ in normal and dystrophic muscle cultures. ...

Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance -
MB REID - Acta Physiologica Scandinavica, 1998 - Blackwell Synergy
... Muscle wasting and differentiation induced by oxidative stress in a murine ... Reactive
oxygen and nitric oxide in skeletal muscle. News Physiol Sci 11, 114 119. ...

BIOMEDICINE: Protein Loss in Cancer Cachexia -
MJ Tisdale - Science, 2000 - sciencemag.org
... as AIDS or cancer (particularly those with tumors of the pancreas, stomach, colon,
and lung) often experience a life-threatening muscle wasting syndrome known ...

Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis -
B Williams, E Layward, J Walls - Clin Sci, 1991 - cs.portlandpress.com
... Britain). Skeletal muscle degradation and nitrogen wasting in rats with
chronic metabolic acidosis. Williams B, Layward E, Walls J. ...

US researchers find key link in muscle-wasting syndrome -
A Pirisi - The Lancet, 2000 - Elsevier
... tissues, we believe that this research may help to shed light on the muscle wasting
component of this syndrome?. ?This is very exciting news?, says Gail ...

Source: Google Scholar

Muscle Wasting More Bad News For Smokers
Researchers at The University of Nottingham have got more bad news for smokers. Not only does it cause cancer, heart attacks and strokes but smokers will also lose more muscle mass in old age than a non-smoker. The effect of this predisposes smokers to an accelerated decline in physical function and loss of independence.

Research has already established that smokers tend to have a lower muscle mass than non-smokers but no one has been able to explain why.
Now, Michael Rennie, a Professor of Clinical Physiology, and Dr Philip Atherton, a Research Fellow, both from the university's School of Graduate Entry Medicine and Health at Derby, have, with collaborators in Denmark and the USA, discovered that smoking impairs the day to day upkeep of muscle. Their research shows that smoking is likely to speed up a condition known as sarcopenia -- the loss of muscle mass with ageing which is linked to poor balance, gait speed, falls, and fractures.

Sixteen people took part in the study which was part funded by the Biotechnology and Biological Sciences Research Council. The men and woman in their mid sixties were selected because of their similar lifestyles in terms of alcohol consumption and physical activity. They were all considered to be healthy, with no symptoms of lung disease. They were studied in two equal groups: heavy smokers, who had smoked at least a pack of 20 cigarettes a day for at least 20 years: and non-smokers.

To measure the synthesis of muscle protein they were given an intravenous infusion of blood with a tagged amino acid (one of the building blocks of protein). Samples of muscle were taken from their thighs before and after the infusion to follow how much had "stuck" in muscle protein. This measured the rate of synthesis of muscle protein which contributes to the daily maintenance of the muscle mass. The researchers found that it was substantially less in smokers than non-smokers.

During extensive studies, carried out in collaboration with Washington University, St Louis and Copenhagen University, Professor Rennie and Dr Atherton discovered that the amounts of myostatin, a muscle growth inhibitor and MAFbx enzyme, which breaks down muscle protein, were higher in smokers than non-smokers.
Dr Philip Atherton said: "From our tests, we can conclude that smoking slows the muscle protein synthesis machinery -- probably impairing day to day upkeep of muscle. We are all well aware of the ill affects of smoking on the lungs but our study reveals yet another cause of ill-health associated with smoking. Hopefully the UK smoking ban will encourage people to quit while they are still young, helping them to keep in good health in later life".

Their research was presented by Dr Atherton at Life Sciences 2007. This is the first joint meeting of the Biochemical Society, the British Pharmacological Society and The Physiological Society. .

The full paper describing their work has been published on line in American Journal of Physiology.

The University of Nottingham is Britain's University of the Year (The Times Higher Awards 2006). It undertakes world-changing research, provides innovative teaching and a student experience of the highest quality. Ranked by Newsweek in the world's Top 75 universities, its academics have won two Nobel Prizes since 2003. The University is an international institution with campuses in the United Kingdom, Malaysia and China.

More information can be found at http://www.lifesciences2007.org/

Source: Professor Michael Rennie
University of Nottingham
 
 
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