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Recent News and Articles on the Keywords: heart disease + gene mutations + common  Related to the article below (Last Update: 5/5/2008)


AFP
Half of people carry 'fat gene'
Telegraph.co.uk, United Kingdom -
In recent times a wide range of genetic variations and mutations linked with expanding waistlines have been identified and scientists working in the field ...
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all 65 news articles »

Scientific American
Are There Missing Pieces to the Human Genome Project?
Scientific American - 15 minutes ago
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Bloomberg -
The mutations are close to a gene called MC4R that is the most common cause of inherited, severe obesity, said researchers led by Ruth Loos, ...
Health Watch: Bird-borne 'bugs' bring health worries
Utica Observer Dispatch, NY -
Behavioral problems, autism and self-injury are also common. Recent genetic discoveries of three gene mutations that cause the syndrome have led to more ...
DNA Testing's Double Bind
Washington Post, United States - Apr 23, 2008
... a mutated gene from each parent will develop the disease. Gessen cites intriguing evidence that certain recessive mutations common among Ashkenazi Jews ...
Tracing the Path from DNA to Dementia
New York Times, United States - Apr 13, 2008
Q. What gene mutations are involved in Alzheimer's disease? A. Three autosomal dominant genes have been identified for early-onset disease. ...
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Men's News Daily, CA - Apr 20, 2008
(As this gene mutation can be passed down to both men and women, men can also be affected by BRCA gene mutations, and they may experience an increased risk ...
Yale study shows how rare genes have big impact on blood pressure
EurekAlert (press release), DC - Apr 6, 2008
A major question in the field of many chronic diseases has been whether the risk of developing a disease is more closely linked to common or rare mutations. ...
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Gather.com, MA - Apr 15, 2008
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FOXBusiness - Apr 23, 2008
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Source: Google News

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate … -
P Frosst, HJ Blom, R Milos, P Goyette, CA Sheppard … - Nature Genetics, 1995 - nature.com
... A candidate genetic risk factor for vascular disease: a common mutation in
methylenetetrahydrofolate ... vascular and coronary heart disease 1-4 ...

Homocysteine and Risk of Premature Coronary Heart Disease Evidence for a Common Gene Mutation -
PM Gallagher, R Meleady, DC Shields, KS Tan, D … - Circulation, 1996 - Am Heart Assoc
... of MTHFR may be an independent risk factor for coronary heart disease. ... 20 Frosst
et al 19 identified a single common mutation of the MTHFR gene that causes ...

… Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease The Result of a … -
L Brattstrom, DEL Wilcken, J Ohrvik, L Brudin - Circulation, 1998 - Am Heart Assoc
... Homocysteine and risk of premature coronary heart disease: evidence for
a common gene mutation. Circulation. 1996;94:2154?2158. ...

… in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease … -
LA Kluijtmans, LP van den Heuvel, GH Boers, P … - American Journal of Human Genetics, 1996 - pubmedcentral.nih.gov
... risk factor for coronary heart disease determined by ... risk factor for vascular disease:
a common ... in the methylenetetrahydrofolate reductase gene and genotype ...

… Is a Risk Factor for Ischemic Heart Disease in White Women When Caused by a Common Mutation in the … -
B Agerholm-Larsen, BG Nordestgaard, R Steffensen, … - Circulation, 2000 - Am Heart Assoc
... HDL Cholesterol Is a Risk Factor for Ischemic Heart Disease in White Women When
Caused by a Common Mutation in the Cholesteryl Ester Transfer Protein Gene. ...

Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, … -
AR Folsom, FJ Nieto, PG McGovern, MY Tsai, MR … - Circulation, 1998 - Am Heart Assoc
... Homocysteine and risk of premature coronary heart disease: evidence for
a common gene mutation. Circulation. 1996;94:2154?2158. ...

… heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene … -
S Zhong, DS Sharp, JS Grove, C Bruce, K Yano, JD … - Journal of Clinical Investigation, 1996 - pubmedcentral.nih.gov
... Risk factors for coronary heart disease in adult female twins. ... lipoprotein levels
caused by a common cholesteryl-ester transfer protein gene mutation. ...

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes … -
… -Huerta, JC Ruiz Cabezas, J Common, PE Purkis, N … - Human Molecular Genetics, 2000 - Oxford Univ Press
... dilated cardiomyopathy often resulting in heart failure during ... is a good candidate
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… Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease -
B Christensen, P Frosst, S Lussier-Cacan, J Selhub … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1997 - Am Heart Assoc
... Polymorphism and Risk of Coronary Heart Disease: A Meta ... of the Methylenetetrahydrofolate
Reductase Gene: Incidence and ... Load Homocysteine in Vascular Disease Clin ...

… , but not of ischemic heart disease. A study of 9,127 individuals based on the Copenhagen City Heart … -
A Tybjaerg-Hansen, B Agerholm-Larsen, SE Humphries … - Journal of Clinical Investigation, 1997 - pubmedcentral.nih.gov
... Abstract. A common mutation (G-455--> A) in the promoter region of the beta-fibrinogen
gene has been ... levels and risk of ischemic heart disease in the ...

Source: Google Scholar

Common gene mutations affect heart disease

 

Last Updated: 2007-07-20 13:01:06 -0400 (Reuters Health)

By Michael Kahn

LONDON - Researchers say they have pinpointed six common genetic variations that may cause heart disease and the discovery may help to predict who is at greatest risk.

A study published on Wednesday in The New England Journal of Medicine said changes in the DNA on the chromosomes were associated with increased risk of developing coronary artery disease and heart attacks.

It confirmed the discovery of researchers who reported earlier this year that mutations on another chromosome raised the risk of heart disease, said Dr. Nilesh Samani, a researcher at Britain 's University of Leicester , who led the study.

 

Carrying one copy of the genetic change increased the chance of developing heart disease by at least 20 percent, while two copies increased the risk by more than 40 percent Samani said.

"Understanding the genetics that lead to heart disease is a powerful tool to tell us how much risk a person faces," Samani said. "We are not talking about rare genetic variants here, but rather variants that are very common in our population."

The findings added to research that might help explain why so many people suffered heart disease even if they had no clear risk factors such as smoking, high cholesterol or high blood pressure, the researchers said.

The research could also pave the way for more effective drugs and better treatment and screening, Samani said.

Scientists have known for years that genes, with environmental factors, play a role in increasing the risk that people will develop problems such as heart disease.

They are still trying to work out which parts of the genome -- the total collection of DNA, including the genes and other genetic material -- are actually responsible.

The researchers looked at 500,000 genetic changes in nearly 2,000 white Europeans with coronary artery disease and 3,000 healthy people.

They then compared the results with a similar German study to pick out the common genetic mutations that indicated a higher risk of heart disease.

"People have identified genetic variants which change risk but this is the best evidence of specific markers," Samani said in a telephone interview.

The next step, he added, was to study larger groups to see how genetic mutations fitted in with other risk factors such as high cholesterol.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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