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Recent News and Articles on the Keywords: hiv + immune + patients  Related to the article below (Last Update: 5/12/2008)


World Press Review
Africa: Getting Old on ARVs
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Venter advised his fellow clinicians to pay particular attention to risk factors like obesity, smoking, and depression in their HIV-positive patients, ...
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Business Wire (press release), CA -
?Although treatment with ART raises T-cell counts and improves patient immune function, its use does not improve the immune system?s ability to control HIV ...

Natural News.com
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Immune correlates of CD4 decline in HIV-infected patients ...
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Health Newstrack
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... care at two larger inner London HIV treatment centres. They also wanted to see what action was taken in order to improve the patients? immune status. ...
Source: Google News

… progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and … -
G Greub, B Ledergerber, M Battegay, P Grob, L … - The Lancet, 2000 - Elsevier
... to by: Why should hepatitis C affect immune reconstitution in HIV-1-infected patients?,
The Lancet, Volume 356, Issue 9245, 2 December 2000, Pages 1865-1866 ...

… hepatitis following treatment of HIV-infected patients with HIV protease inhibitors: an immune … -
M John, J Flexman, MAH French - AIDS, 1998 - aidsonline.com
... Hepatitis C virus-associated hepatitis following treatment of HIV-infected patients
with HIV protease inhibitors: an immune restoration disease? ...

The role of a mutant CCR 5 allele in HIV?1 transmission and disease progression -
Y Huang, WA Paxton, SM Wolinsky, AU Neumann, L … - Nature Medicine, 1996 - nature.com
... immunofluorescence assay, we examined serum samples from 913 patients for the ... 1
neutralizing monoclonal antibodies 2F5 and 2G12, and HIV immune globulin were ...

[PDF] … Virus (HIV)-1 Infection is Mainly Due to Immune Activation: a Longitudinal Analysis in Patients … -
AR Therapy - HIV and the immune system during highly active …, 2000 - igitur-archive.library.uu.nl
T-Cell Division in Human Immunodeficiency Virus (HIV)-1 Infection is Mainly Due
to Immune Activation: a Longitudinal Analysis in Patients Before and During ...
-

Immune Reconstitution in HIV-Infected Patients -
HH Hirsch, G Kaufmann, P Sendi, M Battegay - Clinical Infectious Diseases, 2004 - UChicago Press
All Journals > Clinical Infectious Diseases > 15 April 2004 > Immune Reconstitution
in HIV-Infected Patients. ... Immune Reconstitution in HIV-Infected Patients. ...

Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly … -
MA French, N Lenzo, M John, SA Mallal, EJ McKinnon … - HIV Medicine, 2000 - Blackwell Synergy
... (2005) The prevalence and risk of immune restoration disease in HIV-infected
patients treated with highly active antiretroviral therapy. ...

Temporal association of cellular immune responses with the initial control of viremia in primary … -
RA Koup, JT Safrit, Y Cao, CA Andrews, G McLeod, W … - J Virol, 1994 - pubmedcentral.nih.gov
... in all five patients. These findings suggest that cellular immunity is involved
in the initial control of virus replication in primary HIV-1 infection and ...

Toward an Understanding of the Correlates of Protective Immunity to HIV Infection -
BF Haynes, G Pantaleo, AS Fauci - Science, 1996 - sciencemag.org
... have hypothesized that patients whose immune systems recog- nize fewer immunodominant
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… depletions within the CD4 T-cell repertoire that are not immediately restored by antiviral or immune … -
M Connors, JA Kovacs, S Krevat, JC Gea-Banacloche, … - Nat Med, 1997 - palgrave-journals.com
... Qualitative analysis of immune function in patients with the ... Immunological abnormalities
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… in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune … -
F Miedema, AJ Petit, FG Terpstra, JK Schattenkerk, … - J Clin Invest, 1988 - pubmedcentral.nih.gov
... with the human immunodeficiency virus (HIV) is associated ... monocyte function in acquired
immune deficiency syndrome ... tissue from AIDS patients with encephalopathy ...

Source: Google Scholar

HIV patients build normal immune strength in study

Last Updated: 2007-07-19 13:41:15 -0400 (Reuters Health)

By Will Dunham

WASHINGTON - Combination drug regimens for HIV infection may be able to restore the ravaged immune systems of some patients, researchers reported on Wednesday.

Immune cells known as CD4 T-cells returned to normal levels in a specific group of patients, selected because they responded optimally to a combination of at least three anti-HIV drugs, the researchers reported in The Lancet medical journal.

The human immunodeficiency virus (HIV), which causes AIDS, plunders the immune system, leaving people vulnerable to a range of infections that may prove fatal.

 

 

AIDS can not be cured, but if patients are treated early enough doctors can protect the immune system from further damage with life-extending drug therapy aimed at reducing the amount of virus in the body.

The 5-year study involved 1,835 HIV-infected people drawn from a larger study involving more than 14,000 patients from across Europe , Israel and Argentina .

"I think it's very encouraging that if people can respond to treatment well enough and can suppress the virus for long enough, we have sufficient evidence to say their CD4 counts can return to normal," Dr. Amanda Mocroft of Royal Free and University College Medical School in London , one of the researchers, said in a telephone interview.

"Our previous understanding was that there was a plateau in CD4 counts so that CD4 counts would stop increasing after a sufficiently long time taking combination therapy," she added.

Mocroft said not all HIV patients respond as well to these drugs, and many, particularly in the hardest hit regions like sub-Saharan Africa , do not have access to them.

"This is sort of the best-case scenario, if you like, that we can identify a group of patients who we would expect to have a normal CD4 count with sufficient treatment," Mocroft said.

Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said doctors who care for HIV-infected patients have noticed this restoration of normal levels of CD4 cells in some of them.

Fauci credits Mocroft's team for documenting this phenomenon in a systematic way.

CD4 cells are a type of white blood cell that help protect the body from infection. But HIV targets CD4 cells, using their DNA to create more copies of the virus, thus undermining the immune system.

After initial infection, a person can produce more CD4 cells to take the place of those attacked by HIV. But in time, the body cannot make enough, and the immune system begins with weaken.

The AIDS virus has infected about 40 million people globally, most of them in Africa . It has killed more than 25 million.

 

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
 
 
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