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Recent News and Articles on the Keywords: stem cell + stem cells + treatment  Related to the article below (Last Update: 5/12/2008)

Stem cell treatment gives hope to former Hurst student
Fort Worth Star Telegram, TX -
But an experimental treatment using his own stem cells to stimulate tissue growth is giving the former LD Bell High School wide receiver hope after ...
StemCyte expands
Pasadena Star-News, CA -
The global cell therapy company, with a focus on umbilical cord blood stem cells, moved from a smaller facility in Arcadia. ...
Mesoblast Limited (ASX:MSB) Announce Near Term Commercialization ...
ABN Newswire (press release), Australia -
Indeed, we recently announced highly successful results from the clinical trial at The Royal Melbourne Hospital of our proprietary stem cells in 10 patients ...ASX:MSB - PINK:MBLTY
Adult stem cells safe in gene therapy
Checkbiotech.org (press release), Switzerland -
"These data are critical for advancing stem-cell research leading toward therapies," Nolta said in a statement. "We've shown that adult stem cells follow ...
New Venture For Therapy With Cord Blood And Adult Stem Cells
Medical News Today (press release), UK -
Novussanguis will try to help those patients who could benefit from treatment with adult and cord blood stem cells. Adult stem cells can be harvested from ...
Berglin, DFL push for constitutional amendment to stop raids on ...
Twin Cities Planet, Minnesota -
The bill lays the scientific and medical basis for stem-cell research and defines what can be studied, including embryonic stem cells and adult stem cells. ...
Arsenic-based Therapy Shown To Help Eradicate Leukemia-initiating ...
Science Daily (press release) -
"Leukemia initiating cells share many properties of normal hematopoetic stem cells," explains senior author Pier Paolo Pandolfi, MD, PhD, Director of the ...

Times Online
Nations divided by their view of human life
Times Online, UK - May 9, 2008
At the end of the day, scientists and doctors will have to find a safe way to use stem cells for treatment of diseases that have hitherto been incurable.?
Health & Medicine Investor's Business Daily (subscription)
MD Is Giving Money For Stem Cell Research WMDT
all 27 news articles »
Stem Cell Researchers Demonstrate Safety Of Gene Therapy Using ...
Science Daily (press release) - May 6, 2008
The therapy involves taking hematopoietic stem cells from a person who needs treatment, genetically modifying the cells ? perhaps by adding a missing gene ...
Former nurse is forced to sell her home after forking out ?100000 ...
This is London, UK -
She then forked out ?20000 for two courses of revolutionary stem cell treatment in Germany which has dramatically improved her health but is not approved ...
Source: Google News

Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone … -
S Slavin, A Nagler, E Naparstek, Y Kapelushnik, M … - Blood, 1998 - ncbi.nlm.nih.gov
... abnormal host hematopoietic cells by allogeneic nonmyeloablative stem cell
transplantation represents a potential new approach for safer treatment of a large ...

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem …
K Le Blanc, I Rasmusson, B Sundberg, C … - The Lancet, 2004 - Elsevier
... Our patient had progressive severe GVHD that was unresponsive to all therapy.
Mesenchymal stem-cell treatment had a striking immunosuppressive effect. ...

Multilineage Potential of Adult Human Mesenchymal Stem Cells -
MF Pittenger, AM Mackay, SC Beck, RK Jaiswal, R … - Science, 1999 - sciencemag.org
... was induced in the expanded mesenchymal cell cultures by treatment with 1 ... to
differentiate into multiple cell types in vitro, establishing their stem cell nature ...

Treatment of High-Risk Acute Leukemia with T-Cell-Depleted Stem Cells from Related Donors with One … -
F Aversa, A Tabilio, A Velardi, I Cunningham, A … - New England Journal of Medicine, 1998 - content.nejm.org
... Next Next. Treatment of High-Risk Acute Leukemia with T-Cell?Depleted Stem Cells
from Related Donors with One Fully Mismatched HLA Haplotype. ...

Embryonic Stem Cell Lines Derived from Human Blastocysts -
JA Thomson, J Itskovitz-Eldor, SS Shapiro, MA … - Science, 1998 - sciencemag.org
... link this progress even more closely to the prevention and treatment of human ...
Late-Adhering Human Embryonic Stem Cell Clumps During Serial Passage Can Yield ...

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 -
A Peled, I Petit, O Kollet, M Magid, T Ponomaryov, … - Science, 1999 - sciencemag.org
... Treatment of human cells with antibodies to CXCR4 prevented engraftment. ... 1 of CD34 +
CD38 /low cells correlated with in vivo engraftment and stem cell function ...

Bone marrow stem cells regenerate infarcted myocardium -
D Orlic, J Kajstura, S Chimenti, DM Bodine, A Leri … - Pediatric Transplantation, 2003 - Blackwell Synergy
... of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood
by treatment with granulocyte-colony stimulating factor and stem cell factor. ...

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium -
LB Balsam, AJ Wagers, JL Christensen, T Kofidis, … - Nature, 2004 - nature.com
... reported that an adult BM population enriched for haematopoietic stem cells (HSCs)
(Lin ... in cell-treated hearts, we hypothesized that cell treatment could still ...

[PDF] Stem cells, cancer, and cancer stem cells -
T Reya, SJ Morrison, MF Clarke, IL Weissman? - Nature, 2001 - microarray.princeton.edu
... Although it seems reasonable to propose that each tissue arises from a tissue-specific
stem cell, the rigorous identification and isolation of these somatic ...
-

… of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell -
GS Hodgson, TR Bradley - Nature, 1979 - nature.com
Properties of haematopoietic stem cells surviving 5-fluorouracil treatment:
evidence for a pre-CFU-S cell? GS Hodgson & TR Bradley. ...

Source: Google Scholar

A new method of adult stem cell growth efficacious in treatment of disorders of the cornea

A new method of adult stem cell growth, designed in the Area of Cellular Therapy of the University Clinic (University of Navarra), has demonstrated its efficacy for its capacity to grow cornea stem cells. So Ana Fernández Hortelano, ophthalmologist at the Hospital demonstrated on applying the growth technique in treating diseases of the cornea, using stem cells, in 70 test animals (rabbits). The aim of the procedure was to regain the damaged epithelium and thus restore transparency to the cornea.

In concrete, the thesis defended by doctor Fernández Hortelano at the Faculty of Medicine of the University of Navarra, proves the therapeutic efficiency in using corneal stem cells in patients with pathologies of the cornea, such as caustications or ocular herpes, by using stem cells from a healthy contralateral eye. The technique is being currently applied to patients with satisfactory results.

The research has two essential parts. On the one hand, it describes the design of a new method of cell growth and, on the other, explains the clinical application of the procedure.

Growth in two stages

The research undertaken by the ophthalmologist has shown that, from a small biopsy sample, the new growth technique enables the growth of the number of stem cells thus obtained to the point of obtaining sufficient for the treatment to be effective. The cell sample is taken from the limb of the healthy eye – the ocular structure responsible for the transparency of the cornea.

The importance of this growth method lies in the fact that it enables the characterisation of the cells obtained, i.e. determining the quantity and viability of the units to be used.

The method developed combines culture on a plastic chip with that of an amniotic membrane one. The novelty of the technique focuses on the first stage – where the plastic chip is used. The fragment of tissue obtained from the healthy eye divides into smaller fractions which are grown on the chip. Thus a greater number of halos of stem cells are obtained (as many as the fragments of tissue). A sample of the cells obtained are then sent the Anatomic Pathology laboratory where the viability and quality of the cell units are verified.

The cells are transferred to the amniotic membrane growth culture, one that is highly suitable when dealing with stem cells that are to be transplanted for ocular regeneration treatment.

Once in the amniotic membrane, the stem cells expand in a homogeneous manner, enabling a better cell identification in order to select the most suitable units for the treatment. This method permits finding out with precision the cell population that we are implanting in the eye and to verify, thereby, both the quality and quantity of the cells transplanted.

Clínical application

The second part of the research involved the clinical application of the adult stem cells transplant in rabbits, which previously have had an epithelial corneal lesion induced, causing loss of corneal transparency. This is a pathology that does not respond to a corneal transplant nor to other conventional treatment.

The procedure used by Dr Fernández Hortelano involved obtaining this type of cell – corneal stem cells – by means of a biopsy of cells from a healthy eye of the rabbit. This is a small sample of cells - 3 by 4 mm - and so the contrateral eye is not in danger. A tiny number of cells thus being involved, it is necessary to grow the samples in order to obtain greater numbers of cells, an expansion achieved by transferring the culture to the amniotic membrane.

The adult stem cells obtained are implanted in the damaged eye and the limb is regenerated, this leading to the recovery of the corneal epithelium and, thereby, the transparency of the cornea. The results to date achieved amongst the group of rabbits, with induced limbic insufficiency and which then had a transplant of adult stem cells, showed recovery of the corneal epithelium in 60% of the treated animals. The corneal epithelium is the layer that is damaged with limbic insufficiency, a problem which, in the long term, results in opacity of the cornea.
 
 
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