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Recent News and Articles on the Keywords: angina + stimulation + relieve  Related to the article below (Last Update: 8/5/2008)


Angioplasty.Org
Prediman K. Shah, MD, FACC
Angioplasty.Org, NY - Jul 22, 2008
... or EECP, and spinal chord stimulation -- that is being used I think more in Europe than in this country for relief of refractory angina. ...
Source: Google News

Does pain relief with spinal cord stimulation for angina conceal myocardial infarction? -
C Andersen, P Hole, H Oxh?j - British Heart Journal, 1994 - pubmedcentral.nih.gov
... 419?421. Copyright notice. Does pain relief with spinal cord stimulation
for angina conceal myocardial infarction? C. Andersen, P ...

Dorsal column stimulation for pain relief from intractable angina pectoris. -
DF Murphy, KE Giles - Pain, 1987 - ncbi.nlm.nih.gov
Pain. 1987 Mar;28(3):365-8. Click here to read Dorsal column stimulation for pain
relief from intractable angina pectoris. Murphy DF, Giles KE. ...

Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanisms of … -
C Mannheimer, T Eliasson, B Andersson, CH Bergh, … - BMJ: British Medical Journal, 1993 - pubmedcentral.nih.gov
... Pain relief, increased blood flow, and a possible limb-saving effect ... Manhem K,
Wilhelmsson C. Epidural spinal electrical stimulation in severe angina pectoris ...

Epidural spinal electrical stimulation for severe angina: a study of its effects on symptoms, … -
JE SANDERSON, P BROOKSBY, D WATERHOUSE, RBG PALMER … - European Heart Journal, 1992 - Eur Soc Cardiology
... spinal electrical stimulation in severe angina pectoris. Br Heart J 1988; 59:
56-61. [10] Sanderson JE. Electrical neurostimulators for pain relief in angina. ...

Relief of angina pectoris by electrical stimulation of the carotid-sinus nerves.
E Braunwald, SE Epstein, G Glick, AS Wechsler, NS … - N Engl J Med, 1967 - ncbi.nlm.nih.gov
Relief of angina pectoris by electrical stimulation of the carotid-sinus nerves.
Braunwald E, Epstein SE, Glick G, Wechsler AS, Braunwald NS. ...

Electrical Stimulation Versus Coronary Artery Bypass Surgery in Severe Angina Pectoris The ESBY … -
C Mannheimer, T Eliasson, LE Augustinsson, C … - Circulation, 1998 - Am Heart Assoc
... cord stimulation on pacing-induced angina pectoris. Circulation. 1994;90(suppl
I):I-160. Abstract. Sanderson JE. Epidural neurostimulators for pain relief in ...

… of cardiac pain suppression by spinal cord stimulation: implications for patients with angina … -
MJ CHANDLER, TJ BRENNAN, DW GARRISON, KS KIM, PJ … - European Heart Journal, 1993 - Eur Soc Cardiology
... The clinical decision to employ spinal cord stimulation in patients with angina
should balance the obvious benefit of pain relief against the risk of depriving ...

Spinal electrical stimulation for intractable angina-long-term clinical outcome and safety -
JE SANDERSON, B IBRAHIM, D WATERHOUSE, RBG PALMER - European Heart Journal, 1994 - Eur Soc Cardiology
... as it is an obvious clinical observation that sympa- thetic stimulation, such as
by anxiety or fear, can induce or worsen angina; therefore the relief of pain ...

Epidural electrical stimulation in severe limb ischemia. Pain relief, increased blood flow, and a … -
LE Augustinsson, CA Carlsson, J Holm, L Jiveg?rd - Annals of Surgery, 1985 - pubmedcentral.nih.gov
... Ninety-four per cent of the patients experienced pain relief. ... Vedin A, Wilhelmsson
C. Transcutaneous electrical nerve stimulation in severe angina pectoris. ...

Spinal cord stimulation significantly decreases the need for acute hospital admission for chest pain … -
S Murray, KGS Carson, PD Ewings, PD Collins, MA … - British Medical Journal, 1999 - heart.bmj.com
... 10. Anderson C, Hole P, Oxhoj H. Does pain relief with spinal cord stimulation for
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Source: Google Scholar
 

Spinal cord stimulation relieves severe angina

Last Updated: 2007-05-11 13:36:13 -0400 (Reuters Health)

By David Douglas

NEW YORK (Reuters Health) - Heart-related chest pain or angina is usually treatable with drugs or heart surgery but for people who are not helped by these approaches, spinal cord stimulation may relieve symptoms, German researchers report.

Spinal cord stimulation "is performed by means of an electrode installed in the epidural space and connected to a neurostimulator typically implanted subcutaneously in the upper left abdominal region," the team explains in the May issue of the medical journal Heart.

Dr. Heinz Theres of Charite Hospital, Berlin and colleagues note that there have been no "blinded" studies of this approach because patients can feel whether the spinal cord stimulator is on or off.

Article continues below and (thank you)
 

Unless people cannot tell if they are receiving active or inactive treatment, the results can be compromised by the so-called placebo effect in which expectations lead to perceived benefits.

Spinal cord stimulation at a standard 3 to 5.5 volts induces a prickling sensation. On the other hand, "subthreshold" stimulation at 2 to 4 volts -- which can't be felt -- had not been tested because it was believed to be ineffective.

However, animal studies have shown that stimulation at the lower levels increase blood flow through the skin. So, the researchers studied 12 patients who had already been treated with spinal stimulation for angina and had responded.

They were given four kinds of treatment for 4 weeks at a stretch, in random order. These involved standard spinal cord stimulation for 24 hours per day or for three 2-hour sessions, subthreshold spinal cord stimulation for three 2-hour sessions daily, or a "control" phase using just 0.1 volts for 24 hours per day.

"Patients blinded to active spinal cord stimulation show an improvement in functional status and a reduction in angina," Theres told Reuters Health.

There were no significant differences between standard and subthreshold treatments in terms of the distance patients could walk without developing angina. However, there was a significant reduction in walking distance during the control phase when the stimulator was essentially inoperative.

The frequency of angina attacks and their severity were also significantly worse in the control phase. In fact, the control phase had to be ended early for three patients because of intolerable angina attacks.

The option to use subthreshold stimulation as an active but patient-blinded treatment facilitates future studies, say the investigators, and may extend its clinical application.

"This study opens a completely new field in spinal cord stimulation research," Theres said.

SOURCE: Heart, May 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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