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Recent News and Articles on the Keywords: enzyme + create + researchers  Related to the article below (Last Update: 8/5/2008)

HEC Chairman announces Rs.4 billion grant for SindhUniversity
Trading Markets (press release), CA -
Dr. Dahot said that necessity of Biotechnology was felt years back and in this regard Enzyme and Fermentation Biotechnology Research Laboratory was ...TSE:PSD - OTC:CMTX

Scientific American
Pill Enhances Out-of-Shape Mice's Endurance
Wired News - Jul 31, 2008
When ATP levels fall and AMP levels rise, British researchers have shown that the enzyme acts to crank up ATP production. AICAR mimics AMP, effectively ...
AICAR, GW1516 Are An Exercise In A Pill eMaxHealth.com
all 115 news articles »

Boston Globe
Drugs mimic exercise benefits in mice
Boston Globe, United States - Jul 31, 2008
They zeroed in on an enzyme activated during exercise that helps lower blood sugar and aids cells to burn fat and respond to insulin. ...
Personal Trainer in a Pill Science Now
all 678 news articles »
CNN?s ?Black in America? erroneously portrayed cause of health ...
Flesh and Stone, MN - Aug 2, 2008
Instead the enzyme produces another oxidative molecule, superoxide, which reacts with nitric oxide to create even more powerful and damaging oxiant, ...
Researchers Discover New DNA Binding Activity of E. coli Protein
innovations report (Pressemitteilungen), Germany - Aug 1, 2008
The alpha subunit is the enzyme that actually copies the DNA, and that activity is well-known. However, there are additional parts of the protein that were ...
Nanotechnology adds vital enzyme to water
ZDNet - Jul 26, 2008
This research work will be published in Aldrichimica Acta in September 2008. This paper will be co-signed by Subir Ghorai, a post-doctoral researcher in ...

NHS Choices
Frankincense for osteoarthritis
NHS Choices, UK - Jul 30, 2008
At baseline and 90 days, the patients had fluid taken from the knee joint to look at the concentration of matrix metalloproteinase-3 (MMP3) ? an enzyme ...
Zapping Microbes With Lasers And Enzymes
NBC 11.com, CA - Jul 28, 2008
Researchers fighting the rise of drug-resistant bacteria have found a new guiding light and tapped into the cleansing power of a good cry. ...
Early Findings Create Buzz for Potent Novel Hormone Blocker
MedPage Today, NJ - Jul 25, 2008
Abiraterone is a potent, selective, irreversible inhibitor of an enzyme -- cytochrome P or CYP 17 -- that "catalyzes two independently regulated steroid ...
Nanotechnology Delivers Vital Enzyme In Water
Hard OCP, TX - Jul 27, 2008
Researchers are using nanotechnology to deliver a coenzyme called CoQ10 (ubiquinone) which is ?as vital to our survival as vitamin C.? The nanotechnique ...
Source: Google News

Nanomaterials: A Membrane-Based Synthetic Approach -
CR Martin - Science, 1994 - sciencemag.org
... of nano- materials, can be found in (2, 4). My research group has ... It would be difficult
to make nanowires with diameters this small by lithographic methods. ...

Immobilizing enzymes: how to create more suitable biocatalysts -
UT Bornscheuer - Angew. Chem, 2003 - doi.wiley.com
... Immobilizing Enzymes: How to Create More ... 1] However, even when an enzyme is identified ...
in organic synthesis dating backalmost a century, researchers have tried ...

FUTURE FOOD: BIOENGINEERING: Genetic Engineers Aim to Soup Up Crop Photosynthesis -
CC Mann - Science, 1999 - sciencemag.org
... 1971 Ogren and two other researchers discovered to ... what is called photorespiration,
the enzyme combines with ... rather than carbon dioxide, to create a compound ...

Enzyme or protein immobilization techniques for applications in biosensor design -
WH Scouten, JHT Luong, R Stephen Brown - Trends in Biotechnology, 1995 - Elsevier
... so far, for a specific enzyme entrapped in N ... in protein engineering, may make direct
electron ... food quality control, environmental monitoring and research. ...

Directed evolution: Creating biocatalysts for the future -
FH Arnold - Chemical Engineering Science, 1996 - Elsevier
... Despite intense research into funda- mental features governing protein folding and
func ... on the gene (DNA sequence coding for the enzyme) to create a mutant ...

A brief look at three decades of research on cyanobacterial hydrogen evolution -
FA Lopes Pinto, O Troshina, P Lindblad - International Journal of Hydrogen Energy, 2002 - Elsevier
... engineering was used to create uptake hydrogenase ... Future research should include:
(a) screening for ... of active bidirectional hydrogenase enzyme and decreased ...

Directed evolution of industrial enzymes: an update -
JR Cherry, AL Fidantsef - Current Opinion in Biotechnology, 2003 - Elsevier
... In an attempt to make an enzyme with improved performance ... review, the rapidly expanding
database of new enzyme sequences now allows researchers to rapidly ...

BIOCHEMISTRY: DNA Cuts Its Teeth--As an Enzyme -
E Finkel - Science, 1999 - sciencemag.org
... DNA enzymes in the hands of any researchers who wanted to copy the catalytic sequence.
Explains Breaker, "These would be the simplest enzymes anyone can make. ...

Chemical Strategies for Functional Proteomics* -
GC Adam, EJ Sorensen, BF Cravatt - Molecular & Cellular Proteomics, 2002 - ASBMB
... studies associated with particular classes of enzymes to create chemical probes
with ... group well known affinity labeling reagents, researchers have succeeded ...

Molecular imprints make a mark -
F Flam - Science, 1994 - sciencemag.org
... Other researchers link the functional groups to the templates ... ter reactive chemical
groups in the enzyme molecule ... use the technique not only to create a binding ...

Source: Google Scholar
 

Researchers Create Model of Cancer-Preventing Enzyme, Study How It Works

Proline dehydrogenase is important because it plays a role in apoptosis, the process of cell death, by enabling the creation of superoxide, a highly reactive electron-rich oxygen species. Superoxide is involved in the destruction of damaged cells and therefore is important in preventing the development and spread of cancer. The protein proline dehydrogenase "opens up to allow oxygen to 'steal' electrons" and create a superoxide, said Tommi A. White, an MU doctoral student in biochemistry.

White worked with John J. Tanner, professor of chemistry and biochemistry in MU's College of Arts and Science, and Navasona Krishnan, a doctoral student at the Unviersity of Nebraska-Lincoln, and Donald F. Becker, an associate professor at the University of Nebraska-Lincoln, to create the first model of proline dehydrogenase. Because the human form of this enzyme is difficult to work with, the team studied proline dehydrogenase from the bacteria Thermus thermophilus. They used bioinformatics and biochemical studies to show that this enzyme is functionally similar to the human version, so their results can be generalized to the human version, as well as the bacterial version.

Article continues below and (thank you)
 
Using X-ray crystallography and biochemical analysis, the team created a model of proline dehydrogenase that can tell scientists more about the molecule's structure and functions.

"The three-dimensional model tells us a lot about the structure of the molecules and helps us understand how they work," Tanner said. "This protein is important in cancer prevention because it enables the creation of superoxide, which aid in cell death. Cells aren't meant to live forever, and at some point, they need to die and be destroyed. Cells that are damaged or diseased are usually destroyed in this process. Our structure tells us how oxygen gets access to electrons stored in the enzyme. We think we've identified a gate that opens to let oxygen into the enzyme where the electrons are stored."

In this way, proline dehydrogenase is important in preventing cancer. White said it's unusual for proline dehydrogenase to be involved in such a process because the usual job of this type of enzyme is to transfer electrons to the mitochondrial membrane, not allow them to be attached to oxygen to create highly reactive superoxides.

Tanner and White said they hope to continue to study proline dehydrogenase and the molecules that can inactivate it. They also plan to examine another protein they suspect works in collaboration with proline dehydrogenase to understand how that protein affects the cancer-preventing abilities of proline dehydrogenase.
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