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Recent News and Articles on the Keywords: peptic + nsaids + ulcers  Related to the article below (Last Update: 8/5/2008)

Helicobacter pylori and Peptic Ulcer The New Nation, Bangladesh - Aug 2, 2008 One cause of peptic ulcer is bacterial infection, but some ulcers are caused by long-term use of nonsteroidal anti-inflammatory agents (NSAIDs), ... Examine the World Peptic Ulcer Testing Market Market Wire (press release) - Jul 7, 2008 Conditions or Causes of Peptic Ulcers II-5 H. Pylori: The Major Cause of Peptic Ulcers II-5 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) II-5 Excess Acid ... POZEN Receives Initial FDA Response To PA32540 SPA FOXBusiness - Aug 2, 2008 ... single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers. ...POZN IDEA AG Gives an Update on the Development of Diractin, the ... PharmaLive.com (press release), PA - Jul 29, 2008 ... oral NSAIDs carry a risk of upper gastrointestinal (GI) side effects, with up to 30% of long-term NSAID users developing gastric ulcers, for example. ... SSRIs and Venlafaxine Linked to Greater Risk for Gastrointestinal ... Medscape (subscription) - Jul 14, 2008 Most patients had bleeding from a peptic ulcer, but others had gastric or duodenal erosions. The case-patients were matched by age and sex with 10000 ... Blood groups, health & nature Central Chronicle, India - Jul 24, 2008 Price's text book of medicine mentions that people belonging to O group of blood are prone to peptic ulcers and cataracts. Certain diseases are confined to ... Antidepressants tied to gastrointestinal bleeding Reuters India, India - Jul 7, 2008 Such risk factors for gastrointestinal bleeding include a peptic ulcer or being elderly, he said. Some SSRIs include: Forest Laboratories Inc's Celexa ... POZEN Reports Second Quarter 2008 Results Business Wire (press release), CA - Jul 29, 2008 ... single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers. ...POZN POZEN to Present at the 2008 BMO Capital Markets Focus on ... MarketWatch - Jul 24, 2008 ... single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers. ...POZN POZEN Announces July 29, 2008 Webcast of Second Quarter 2008 Results WELT ONLINE, Germany - Jul 15, 2008 ... single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers. ...POZN

NSAIDs and Peptic Ulcers

A peptic ulcer is a sore that forms in the lining of the stomach or the duodenum (the beginning of the small intestine). An ulcer can cause a gnawing, burning pain in the upper abdomen; nausea; vomiting; loss of appetite; weight loss; and fatigue. Most peptic ulcers are caused by infection with the bacterium Helicobacter pylori (H. pylori). But some peptic ulcers are caused by prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen sodium.

Normally the stomach has three defenses against digestive juices: mucus that coats the stomach lining and shields it from stomach acid, the chemical bicarbonate that neutralizes stomach acid, and blood circulation to the stomach lining that aids in cell renewal and repair. NSAIDs hinder all of these protective mechanisms, and with the stomach's defenses down, digestive juices can damage the sensitive stomach lining and cause ulcers.

NSAID-induced ulcers usually heal once the person stops taking the medication. To help the healing process and relieve symptoms in the meantime, the doctor may recommend taking antacids to neutralize the acid and drugs called H2-blockers or proton-pump inhibitors to decrease the amount of acid the stomach produces.

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Medicines that protect the stomach lining also help with healing. Examples are bismuth subsalicylate, which coats the entire stomach lining, and sucralfate, which sticks to and covers the ulcer.

If a person with an NSAID ulcer also tests positive for H. pylori, he or she will be treated with antibiotics to kill the bacteria. Surgery may be necessary if an ulcer recurs or fails to heal, or if complications like severe bleeding, perforation, or obstruction develop.

Anyone taking NSAIDs who experiences symptoms of peptic ulcer should see a doctor for prompt treatment. Delaying diagnosis and treatment can lead to complications and the need for surgery.

Additional Information on NSAIDs and Peptic Ulcers

The National Digestive Diseases Information Clearinghouse collects resource information on digestive diseases for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Reference Collection. This database provides titles, abstracts, and availability information for health information and health education resources. The NIDDK Reference Collection is a service of the National Institutes of Health.

To provide you with the most up-to-date resources, information specialists at the clearinghouse created an automatic search of the NIDDK Reference Collection. To obtain this information, you may view the results of the automatic search on NSAIDs and Peptic Ulcers.

If you wish to perform your own search of the database, you may access and search the NIDDK Reference Collection database online.

National Digestive Diseases Information Clearinghouse

2 Information Way
Bethesda, MD 20892–3570
Email: nddic@info.niddk.nih.gov

The National Digestive Diseases Information Clearinghouse (NDDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1980, the Clearinghouse provides information about digestive diseases to people with digestive disorders and to their families, health care professionals, and the public. The NDDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about digestive diseases.

Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts.

This publication is not copyrighted. The Clearinghouse encourages users of this publication to duplicate and distribute as many copies as desired.

NIH Publication No. 04–4644
September 2004