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Recent News and Articles on the Keywords: cancer + directly + target  Related to the article below (Last Update: 8/5/2008)

Nanomagnets tackle cancer
Science News -
This coating can also be studded with antibodies to selectively bind to receptors found on the surface of a target, such as a cancer cell. ...
Shape of nano particles adds edge to cancer therapy
Fresh News, India -
Studies have shown that drug-carrying nanoparticles can directly target tumours, thanks to their infinitesimal size - less than 100 nanometres (a nanometre ...
Blackbaud, Inc. Announces Second Quarter 2008 Results and Third ...
Business Wire (press release), CA -
Chardon continued, ?During the quarter, we added two new Enterprise CRM customers, including the upgrade of an existing Target Team Approach customer. ...
Blackbaud, Inc. Announces Second Quarter 2008 Results and Third ... TMC Net
all 17 news articles »  BLKB
Pentagon spends $300M to study troops' stress, trauma
USA Today -
The money ? the most spent in one year on military medical research since a $210 million breast cancer study in 1993 ? will fund 171 research projects on ...
The case for a regulated breast screening programme
Times of Malta, Malta - Aug 3, 2008
In that year, a breast cancer mortality reduction of approximately eight per cent among the entire UK female population was attributed directly to the UK ...
ASCO 2008: The Evolving Role of EGFR Inhibitors in Colorectal Cancer
Cancer Consultants, ID - Jul 31, 2008
Researchers have been hopeful that combining biologic therapies that target different pathways may provide additive benefit for the treatment of various ...
Target Presents Variety's Power of Youth: Q&A
Variety, CA - Jul 31, 2008
An unprecedented eighty-five cents of every dollar received by St. Jude goes directly to research and treatment. Q: What is Target's affiliation with St. ...
Researchers use magnetic nanoparticles to maneuver cancer cells
Neoseeker - Jul 16, 2008
"If you modify the nanoparticle and target it directly to the tumor cells using a small peptide, you are less likely to generate an undesirable immune ...
Scientists Develop Sensitive Salivary Sensor
Kansas City infoZine, MO - Aug 3, 2008
But as scientists now construct the first of these saliva tests for early signs of cancer and other diseases, they continue to push the technological ...
Houston Meeting Highlights: Physics and the Future of Medicine
Newswise (press release) - Jul 29, 2008
To treat cervical cancer, clinicians apply a high dose of radiation directly to diseased tissues, which may be administered using a device called an ...
AAPM Cancer Research Highlights Medical News Today (press release)
all 18 news articles »
Source: Google News

The phosphatidylinositol 3-Kinase?AKT pathway in human cancer -
I Vivanco, CL Sawyers - Nature Reviews Cancer, 2002 - computableplant.ics.uci.edu
... model systems, and therapeutic strategies that target the PI3K ... became a focus in
the cancer-research field ... p85 is directly associated with many active tyrosine ...

A cancer therapy resistant to resistance -
RS Kerbel - Nature, 1997 - nature.com
... is encountered in about 30 per cent of all cancer patients undergoing ... anti-tumour
agents such as cyclophosphamide, which directly target genetically unstable ...

NF-kappa B in cancer: from innocent bystander to major culprit -
M Karin, Y Cao, FR Greten, ZW Li? - Nature Reviews Cancer, 2002 - nature.com
... of tumorigenesis, including promoting cancer-cell proliferation ... cell proliferation
by activating target genes such ... has also been shown to directly stimulate the ...

… between the Phosphoinositide 3-Kinase-AKT Signaling Pathway and the Mammalian Target of Rapamycin in … -
A Sekulic, CC Hudson, JL Homme, P Yin, DM … - Cancer Research, 2000 - AACR
... These results demonstrate that mTOR is a direct target of the PI3K-AKT signaling ...
Furthermore, the activation status of the PI3K-AKT pathway in cancer cells may ...

The STATs of cancer?new molecular targets come of age -
H Yu, R Jove - Nat Rev Cancer, 2004 - devcell.bio.uci.edu
... to be shown at the chromosomal level that candidate target genes are directly regulated
by ... signalling pathways that are commonly activated in cancer cells ...

[PDF] COLORECTAL CANCER PREVENTION AND TREATMENT BY INHIBITION OF CYCLOOXYGENASE-2 -
RA Gupta, RN DuBois? - Nature Reviews Cancer, 2001 - nature.com
... identification of a molecular target ? cyclooxyge- nase-2 ... COX-2- generated products
directly modulate cellular ... do not reducecolorectal cancer growth entirely ...

Improving the efficacy of antibody-based cancer therapies -
P Carter - Nat Rev Cancer, 2001 - nature.com
... known as HER2/NEU) 8 ? in metastatic breast cancer, the OVERALL ... 9 . All clinically
approved and most experimental anti- bodydrugs directly target tumour cells ...

… Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer … -
F Chang, JT Lee, PM Navolanic, LS Steelman, JG … - Leukemia, 2003 - nature.com
... PI3K/Akt pathway is a viable target for novel ... tumors including breast cancer, 14
lung cancer, 15 melanomas ... was shown that Akt could directly phosphorylate both ...

Direct activation of the apoptosis machinery as a mechanism to target cancer cells -
JT Nguyen, JA Wells - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... BIOCHEMISTRY Direct activation of the apoptosis machinery as a mechanism to
target cancer cells. Jack T. Nguyen , and James A. Wells *. ...

Histone deacetylases and cancer: causes and therapies -
PA Marks, RA Rifkind, VM Richon, R Breslow, T … - Nature Reviews Cancer, 2001 - nature.com
... Cancer Lett. 78, 1?5 (1994). ... Histone deacetylase is a direct target of valproic acid,
a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. ...

Source: Google Scholar
 

Australian scientists directly target cancer cells

Last Updated: 2007-05-10 9:54:04 -0400 (Reuters Health)

SYDNEY - An Australian biotechnology firm said on Thursday it had developed a means of delivering anti-cancer drugs directly to cancer cells, which aims to avoid the debilitating toxicity associated with chemotherapy.

The method uses nanotechnology, which involves molecules far smaller than a human cell.Direct targeting of chemotherapy drugs would allow dosages thousands of times lower than that in conventional chemotherapy and be more easily tolerated by patients, said the firm.

Writing in the May issue of U.S.-based Cancer Cell journal, the biotech firm EnGeneIC said it had developed nano-cells containing chemotherapy drugs.

Article continues below and (thank you)
 

Via antibodies on their surface, these nano-cells target and latch on to cancer cells. Once attached, the nano-cell is engulfed and the drug is released directly inside the cancer cell.

The firm said the bacterially derived nano-cell, called EnGeneIC delivery vehicles, had proven safe in primate trials and resulted in significant cancer regression.

It hoped to carry out human trials later in 2007 if it gained approval from Australian, U.S., European and Japanese regulatory authorities.

"For the first time there is a real possibility that this technology could lead to the use of multi-drug combinations and eventual custom-made therapies in cancer patients," research scientist Jennifer MacDiarmid said in a statement.

"In terms of tumor therapy, most late-stage cancer patients carry tumor cells that exhibit various forms of drug resistance. Our technology may provide the first in-vivo (inside an organism) solution to this serious hurdle."

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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