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Recent News and Articles on the Keywords: breast + cancer + linked  Related to the article below (Last Update: 8/5/2008)


Times Colonist
Genetic discovery offers hope to family with legacy of cancer
Canada.com, Canada -
Luana Locke was 25 and eight months pregnant when she was diagnosed with breast cancer. Although she gave birth to a healthy son, she had no idea she had ...
Genetic discovery may lead to new blood test for people at high ... Canada NewsWire (press release)
all 48 news articles »
Early screening is crucial to improving recovery rates for breast ...
Orlando Sentinel, FL - 48 minutes ago
"One in eight women develops breast cancer by the age of 80." While obesity, alcohol intake and hormone-replacement therapy all have been linked to breast ...

TopNews
Strong Bones Linked to Breast Cancer
U.S. News & World Report, DC - Jul 28, 2008
A new study links having strong bones to an elevated risk of breast cancer. At first blush, that seems to put women in a bind: tumor if you do, ...
New Study Shows Bone Density Linked To Breast Cancer Risk dBTechno
Bone Density of Hip Connected to Breast Cancer Risk After Menopause MedPage Today
Study Finds Causal Relationship Between High Bone Density and ... eFluxMedia
all 54 news articles »
Nanomagnets tackle cancer
Science News -
His group attached antibodies that bind to receptors on breast cancer cells. Then they injected the nanomagnets into mice that had been seeded with those ...
BMI linked to cancer mortality
News24, South Africa - Jul 29, 2008
New York - A higher body mass index (BMI) is associated with lower survival rates in women with breast cancer, according to a report in the July 10th issue ...

eFluxMedia
Pan Mass Challenge Riders Raise Funds for Cancer Research
eFluxMedia -
Almost 4000 people are diagnosed with cancer daily in the US Breast cancer is the leading cause of cancer death among women worldwide. Cancer is more common ...

PhysOrg.com
Breakthrough: Scientists discover vital new link between radiation ...
Daily Mail, UK - Jul 31, 2008
The study sheds new light on a vital enzyme that could be linked to breast cancer susceptibility. The study sheds new light on a vital enzyme that enables ...
Exercise Found To Lower Risk Of Premenopausal Breast Cancer The Healthier Life
all 3 news articles »
Dragon boats race for a cause
BurlingtonFreePress.com, VT - Aug 4, 2008
Following a moment of silence, each of the women competing on the 13 breast cancer survivor teams ? who had battled the disease and survived ? set a pink ...

OverTheLimit.info
Hip Bones May Help Predict Breast
Oneindia, India - Jul 31, 2008
Assessing the hip-bone density may help predict breast cancer risk in older, postmenopausal women. Bone mineral density testing is done to diagnose ...
Study Shows Strong Bones Can Mean High Breast Cancer Risk E Canada Now
Strong Bones Linked to Breast Cancer in Older Women MedHeadlines
Bone Mineral Density Predicts Breast Cancer Risk eMaxHealth.com
all 20 news articles »
Sorting Out Coffee?s Contradictions
New York Times, United States -
... tea or caffeine consumption and breast cancer. Bone loss. Though some observational studies have linked caffeinated beverages to bone loss and fractures ...
Source: Google News

… of BRCA 1 by analysis of germline mutations linked to breast and ovarian cancer in ten families -
LS Friedman, EA Ostermeyer, CI Szabo, P Dowd, ED … - Nature Genetics, 1994 - nature.com
... ng1294-399 Confirmation of BRCA1 by analysis of germline mutations linked to
breast and ovarian cancer in ten families. Lori S. Friedman ...

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. -
DF Easton, D Ford, DT Bishop - American Journal of Human Genetics, 1995 - pubmedcentral.nih.gov
... lifetime-risk estimates are obtained by examining the risks of contralateral breast
cancer and of ovarian cancer, in breast cancer cases in linked families. ...

The complete BRCA 2 gene and mutations in chromosome 13 q-linked kindreds -
SV Tavtigian, J Simard, J Rommens, F Couch, D … - Nature Genetics, 1996 - nature.com
... al. A strong candidated for the 17q-linked breast and ovarian cancer
susceptibility gene BRCA1. Science. 266, 66-71 (1994). | PubMed ...

Cancer Risks in Two Large Breast Cancer Families Linked to BRCA2 on Chromosome 13q12-13 -
DF Easton, L Steele, P Fields, W Ormiston, D … - The American Journal of Human Genetics, 1997 - UChicago Press
Page 1. Am. J. Hum. Genet. 61:120?128, 1997 Cancer Risks in Two Large Breast
Cancer Families Linked to BRCA2 on Chromosome 13q12-13 ...

… linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer … -
DF Easton, DT Bishop, D Ford, GP Crockford - American Journal of Human Genetics, 1993 - pubmedcentral.nih.gov
... Under the genetic model used in the analysis, the best estimate of the proportion
of linked breast-ovarian cancer families was 1.0 (lower LOD-1 limit 0.79). ...

Germline mutations of the BRCA 1 gene in breast and ovarian cancer families provide evidence for a … -
SA Gayther, W Warren, S Mazoyer, PA Russell, PA … - Nature Genetics, 1995 - nature.com
... Goldgar, DE et al. A large kindred with 17q-linked breast and ovarian cancer genetic,
phenotypic and genealogic analysis. J. natnl. Cancer Inst. ...

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families -
D Ford, DF Easton, M Stratton, S Narod, D Goldgar, … - The American Journal of Human Genetics, 1998 - UChicago Press
... by the Breast Cancer Linkage Consortium. Families were included without regard to
the occurrence of ovarian or other cancers. Overall, disease was linked to ...

Decreased expression of BRCA 1 accelerates growth and is often present during sporadic breast cancer … -
ME Thompson, RA Jensen, PS Obermiller, DL Page, JT … - Nature Genetics, 1995 - nature.com
... | PubMed | ISI | ChemPort |; Friedman, LS et al.Confirmation of BRCA by analysis
of germline mutations linked to breast and ovarian cancer in ten families. ...

A single BRCA 2 mutation in male and female breast cancer families from Iceland with varied cancer … -
S Thorlacius, G Olafsdottir, L Tryggvadottir, S … - Nature Genetics, 1996 - palgrave-journals.com
... Linkage to BRCA2 region in hereditary male breast cancer. ... The complete BRCA2 gene
and mutations in chromosome 13q-linked kindreds. Nature Genet. ...

Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer. -
H Tulinius, V Egilsson, GH Olafsd?ttir, H … - BMJ: British Medical Journal, 1992 - pubmedcentral.nih.gov
... DESIGN--Cohort study of 947 pedigrees in which the proband had breast cancer,
linked with the Icelandic cancer registry. SETTING--Iceland. ...

Source: Google Scholar
 

Combination HRT linked to lower-risk breast cancers

Last Updated: 2007-05-09 15:54:58 -0400 (Reuters Health)

NEW YORK (Reuters Health) - The types of breast tumors that occur after combination hormone replacement therapy in women going through menopause and in post-menopausal women tend to have a better prognosis than those that occur after estrogen-only replacement therapy, Swedish researchers report.

A team at Malmo University Hospital conducted a study involving 12,583 peri- or post-menopausal women whose medical records were linked to national cancer registries. Of the group, 513 had a history of breast cancer prior to enrollment. During an average of 4.5 years of follow-up, 332 cases of breast cancer were diagnosed, lead investigator Dr. Signe Borgquist and colleagues report in the International Journal of Cancer.

Tumor samples from 283 breast cancers were analyzed for tumor type, grade, estrogen and progesterone receptor status, expression of tumor suppressor genes and other factors.

Article continues below and (thank you)
 

Among the 2,369 current users of hormone replacement therapy, 1,347 used combined therapy and 984 used estrogen-only therapy; 38 women reported using progestin-only therapy. The incidence of breast cancer was higher in combination hormone replacement users than in non-users, and the estrogen replacement only users did not have a significantly increased risk of breast cancer.

The risk profile of breast cancers developing after combination hormone replacement therapy was more favorable than tumors that occurred in women who received estrogen replacement therapy alone.

Specifically, combination therapy was associated with more grade 1 tumors and more tumors that divided slowly than tumors that recurred after estrogen-only hormone replacement therapy.

Borgquist and colleagues conclude, "These findings correspond well with the image of combination hormone replacement therapy as related to tumors with a favorable prognosis."

"To date," they add, "no other study has reported on the association between combination hormone replacement therapy and cell cycle regulators."

SOURCE: International Journal of Cancer, May 15, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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