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Recent News and Articles on the Keywords: osteoporosis treatment + osteoporosis + without  Related to the article below (Last Update: 8/5/2008)

Evaluation of Patients with a recent Clinical Fracture and ...
7thSpace Interactive (press release), NY -
The purpose of this study was to determine the prevalence of contributors to secondary osteoporosis in patients presenting with a clinical vertebral or ...

Daily Mail
Doctor, I've got a bone to pick with you... The bone problems that ...
Daily Mail, UK -
Meanwhile, a recent study by the University of Derby has highlighted shortfalls in treatment for those with osteoporosis, finding that as few as one in ...
MDRNA lays off 23 more employees
Seattle Post Intelligencer -
... since early November, when partner Procter & Gamble pulled out of an agreement to co-develop a nasal treatment for osteoporosis with the company. ...
MDRNA laying off 30% of its staff, including president Seattle Times
all 13 news articles »
LOCAL UPDATES
Grand Forks Herald, ND -
My New View: RiverView Health?s My New View program will host ?Osteoporosis: It?s Beatable. It?s Treatable? from 3 to 6 pm Thursday on the main RiverView ...
UPDATE: Amgen Bone-Drug Study Cuts Failure Risk;Data Awaited
CNNMoney.com - Jul 28, 2008
Those data are vital because denosumab will attempt to enter a crowded osteoporosis market that already includes a popular and cheap generic version of ...AMGN
Amgen Rises After Bone-Drug Test, Analyst Upgrades (Update2)
Bloomberg - Jul 28, 2008
A three-year trial of 7800 women with osteoporosis found that the medicine, denosumab, strengthened bones and reduced fractures in the spine, hip and other ...AMGN
Amgen shares, propped by bone drug, may move higher
guardian.co.uk, UK - Aug 1, 2008
But the magnitude of the improvement -- which investors are eager to compare to existing osteoporosis drugs -- won't be known until mid-September when ...AMGN
Amgen 2nd-qtr profit falls but tops Wall Street
guardian.co.uk, UK - Jul 28, 2008
Treatment with the drug resulted in a statistically significant reduction in new vertebral fractures compared to placebo. "I have to say I'm extremely ...AMGN
Amgen reports 8% drop in profit, but lifts forecast
MarketWatch - Jul 28, 2008
Earlier Monday, shares of Amgen soared in the wake of positive Phase III clinical data for its drug candidate denosumab, a treatment for osteoporosis in ...AMGN
Bone Drug's Trial Success Heals Amgen Shares
Smartmoney.com - Jul 28, 2008
Postmenopausal osteoporosis represented $6 billion in potential drug sales in 2005, and as the baby-boom generation ages, the disease will become more ...AMGN
Source: Google News

Alendronate Prevents Postmenopausal Bone Loss in Women without Osteoporosis: A Double-Blind, … -
M McClung, B Clemmesen, A Daifotis, NL Gilchrist, … - Annals of Internal Medicine, 1998 - annals.highwire.org
... However, half of women who would have sustained fractures without treatment still
do so with treatment. Thus, preventing rather than treating osteoporosis is a ...

… Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis. -
UA Liberman, SR Weiss, J Broll, HW Minne, H Quan, … - Obstetrical & Gynecological Survey, 1996 - obgynsurvey.com
... years of age and postmenopausal with osteoporosis were eligible ... of height in the
women without new vertebral ... was small and similar in the treatment and placebo ...

Fracture Risk Reduction with Alendronate in Women with Osteoporosis: The Fracture Intervention Trial -
DM Black, DE Thompson, DC Bauer, K Ensrud, T … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc
... existing vertebral fractures and those without such fractures ... is evident early in
the course of treatment. ... of alendronate in women with osteoporosis than that ...

… of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene … -
B Ettinger, DM Black, BH Mitlak, RK Knickerbocker, … - JAMA, 1999 - Am Med Assoc
... women without osteoporosis, 1 we found about a 2% to 3% increase in spine and hip
bone mineral density after 2 and 3 years of raloxifene treatment compared ...

Treatment of Osteoporosis: Are Physicians Missing an Opportunity?* -
KB Freedman, FS Kaplan, WB Bilker, BL Strom, RA … - The Journal of Bone and Joint Surgery, 2000 - JBJS
... treat- ment without bone-density testing. 5. The Food and Drug Administration-approved
pharmacological options for osteoporosis prevention or treatment, or both ...

… Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis A … -
ST Harris, NB Watts, HK Genant, CD McKeever, T … - JAMA, 1999 - Am Med Assoc
... Prevention of fractures is the primary goal of osteoporosis treatment.
In this study, risedronate therapy decreased the incidence ...

… of Osteoporotic Fractures in the United States in 1995: Report from the National Osteoporosis … -
NFOX RAY, JK CHAN, MAE THAMER, LJ MELTON III? - Journal of Bone and Mineral Research, 1997 - Am Soc Bone Min Res
... hospitalized 4.4 days longer than those without mention of ... physical therapy sessions
attributable to osteoporosis were either for the treatment of hip ...

… Fractures in Postmenopausal Women With Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) … -
JY Reginster, E Seeman, MC De Vernejoul, S Adami, … - Obstetrical & Gynecological Survey, 2005 - obgynsurvey.com
... or interven- tional radiologists) and put into clinical use without extensive clinical ...
trial, 3 different techniques of colposuspension for treatment of stress ...

Treatment of postmenopausal osteoporosis -
PD Delmas - The Lancet, 2002 - Elsevier
... which involved 7705 women with osteoporosis, indicate that ... in women with and without
prevalent vertebral ... respectively, happens after treatment with raloxifene. ...

The effect of raloxifene on risk of breast cancer in postmenopausal women -
SR Cummings, S Eckert, KA Krueger, D Grady, TJ … - feedback, 2005 - biomedcentral.com
... at the prospect of being able to treat osteoporosis without increasing the ... be considered
when evaluating the risks and benefits of treatment with raloxifene. ...

Source: Google Scholar
 

Osteoporosis Treatment -- Without Estrogen

A class of drugs called bisphosphonates has become the new mainstay treatment for postmenopausal women diagnosed with osteoporosis in the post-hormone-replacement era. Taking just one pill a week, or even one a month, may prevent, slow or stop the breakdown and progress of this bone-thinning condition, according to the May issue of Mayo Clinic Women’s HealthSource.

An estimated 10 million Americans, mostly women, have osteoporosis, where bones become weak and highly prone to fractures. Millions more have low bone density (osteopenia), which can increase the risk of fractures.

Bone -- a living tissue -- is constantly remodeling, with old bone breaking down and new bone replacing it. Bisphosphonates work by slowing the breakdown and reabsorption of old bone, an ongoing process that accelerates as estrogen levels fall during the first few years after menopause. By slowing the process, bisphosphonates help preserve bone density and reduce the risk of fractures.

Article continues below and (thank you)
 

Estrogen once was commonly prescribed to reduce bone loss. But when the landmark Women’s Health Initiative Study, released in 2002, showed that long-term estrogen use increased the risk of breast cancer, heart attacks, strokes and blood clots, hormone therapy fell out of favor.

Bisphosphonates have filled the void and perform as well as estrogen in preventing bone loss. Bisphosphonates available to treat osteoporosis include alendronate (Fosamax), ibandronate (Boniva) and risedronate (Actonel).

Patients should talk with a doctor about the best ways to prevent and treat osteoporosis. Bisphosphonates have potential side effects, most commonly heartburn and abdominal pain caused by irritation of the esophagus or stomach. Even when taking medications, patients should take steps to protect bones, including consuming adequate calcium and vitamin D; engaging in regular weight-bearing exercise such as walking and weight training; and avoiding smoking and excessive use of alcohol.
 
 
 
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