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Recent News and Articles on the Keywords: crohn's disease + crohn's disease: + disease  Related to the article below (Last Update: 8/5/2008)

Osiris Announces Second Quarter 2008 Financial Results Conference Call
Centre Daily Times, PA -
... including acute and steroid refractory Graft versus Host Disease and also Crohn's disease, and is the only stem cell therapeutic currently designated by ...OSIR
Hygiene may be tied to bowel disease
Stuff.co.nz, New Zealand - Aug 3, 2008
Researchers have already begun studying whether exposure to harmless parasitic worms might help treat Crohn's or colitis. Studies have not yet investigated ...
Dad hits the road for daughter
Berkeley Independent, SC -
Crohn?s disease and ulcerative colitis are collectively known as inflammatory bowel diseases (IBD). Crohn's disease is a chronic disorder that causes ...
UAB Inflammatory Bowel Disease Center draws patients from ...
The Birmingham News - al.com, AL - Aug 4, 2008
The center sees a wide variety of patients, but mostly those diagnosed with ulcerative colitis or Crohn's disease, both inflammatory bowel disease and both ...
Help Jordanne fight Crohn's Disease
WBIR-TV, TN - Jul 31, 2008
... PM Posted: 7/31/2008 5:20:42 PM Eight-year-old Jordanne Clabo is like any other eight year old except for one thing, she's fighting Crohn's Disease. ...
New drug on PBS for Crohn's disease
The Age, Australia - Jul 24, 2008
About 3000 Crohn's disease sufferers will be able to access a subsidised drug to treat the condition from next week. Crohn's disease is an inflammatory ...
Vanderbilt co-sponsoring free event on living with Crohn's disease ...
Vanderbilt University News, TN - Jul 30, 2008
"The Road to a Healthier Life with Crohn?s Disease & Ulcerative Colitis," a free event for patients, families and health care professionals about ...
Karting is 1st step for youth
Indianapolis Star, United States - Jul 31, 2008
In June 2007, just weeks before the Race for Riley, Brooks was diagnosed at Riley Hospital for Children with Crohn's disease, a chronic autoimmune disease ...

RTE.ie
RPT-UPDATE 1-Biogen, Elan report Tysabri brain disease cases
Forbes, NY - Jul 31, 2008
... Massachusetts-based Biogen, also won US approval this year to treat adults with moderate to severe Crohn's disease who have had a poor response to, ...
No mercy from a sceptical market Irish Times
Elan, Biogen Shares Plunge on New Tysabri Infections (Update3) Bloomberg
Despite risks, many staying with Tysabri Boston Globe
WebMD
all 217 news articles »  ELN - BIIB - PINK:ELNCF
Pregnancy & Crohn's Disease
Boston Channel.com,  USA - Jul 28, 2008
For Elizabeth Kelly, that meant more than eating right and exercising ? it meant bringing her Crohn?s Disease under control. ?I have always had the attitude ...
Source: Google News

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. -
JP Hugot, M Chamaillard, H Zouali, S Lesage, JP … - Nature, 2001 - ncbi.nlm.nih.gov
Click here to read Comment in: Nature. 2001 May 31;411(6837):537, 539. Association
of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. ...

… -Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor {alpha} for Crohn's Disease -
SR Targan, SB Hanauer, SJH van Deventer, L Mayer, … - New England Journal of Medicine, 1997 - content.nejm.org
... Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases. ...
mucosal tumour necrosis factor {alpha} production in Crohn's disease can be ...

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease -
DH Present, P Rutgeerts, S Targan, SB Hanauer, L … - New England Journal of Medicine, 1999 - content.nejm.org
... Treating Crohn's Disease by Inducing T Lymphocyte Apoptosis. Ann. NY Acad. ... Potential
therapeutic uses of interleukin 1 receptor antagonists in human diseases. ...

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease -
Y Ogura, DK Bonen, N Inohara, DL Nicolae, FF Chen, … - Nature, 2001 - nature.com
... NPG Library. Nature. A frameshift mutation in NOD2 associated with
susceptibility to Crohn's disease. Ogura, Y., Bonen, DK, Inohara ...

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
WR Best, JM Becktel, JW Singleton, F Kern Jr - Gastroenterology, 1976 - ncbi.nlm.nih.gov
Development of a Crohn's disease activity index. National Cooperative Crohn's
Disease Study. Best WR, Becktel JM, Singleton JW, Kern F Jr. ...

A simple classification of Crohn's disease: report of the Working Party for the World Congresses of …
C Gasche, J Scholmerich, J Brynskov, GD'Haens, SB … - Inflamm Bowel Dis, 2000 - ncbi.nlm.nih.gov
2000 Feb;6(1):8-15. A simple classification of Crohn's disease: report of the Working
Party for the World Congresses of Gastroenterology, Vienna 1998. ...

Methotrexate for the Treatment of Crohn's Disease -
BG Feagan, J Rochon, RN Fedorak, EJ Irvine, G Wild … - New England Journal of Medicine, 1995 - content.nejm.org
... METHOTREXATE FOR CROHN'S DISEASE. JWatch General 1995: 3-3 [Full Text]; Weinblatt,
ME (1995). Methotrexate for Chronic Diseases in Adults. ...

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British … -
J Hampe, A Cuthbert, PJP Croucher, MM Mirza, S … - The Lancet, 2001 - Elsevier
... Association between insertion mutation in NOD2 gene and Crohn's disease in German
and British populations. ... Cohort, Crohn's disease, Ulcerative colitis, Total. Cases ...

Mapping of a susceptibility locus for Crohn's disease on chromosome 16 -
JP Hugot, P Laurent-Puig, C Gower-Rousseau, JM … - Nature, 1996 - nature.com
... CROHN'S disease (CD) and ulcerative colitis are the major forms of chronic inflammatory
bowel diseases in the western world, and occur in young adults with an ...

European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment. -
H Malchow, K Ewe, JW Brandes, H Goebell, H Ehms, H … - Gastroenterology, 1984 - ncbi.nlm.nih.gov
Gastroenterology. 1984 Feb;86(2):249-66. European Cooperative Crohn's
Disease Study (ECCDS): results of drug treatment. Malchow ...

Source: Google Scholar
 

Crohn's Disease

Crohn's disease is an inflammatory bowel disease (IBD) that causes painful swelling in the lining of the affected organ. Crohn's disease normally affects the small intestine, but it can occur anywhere along the digestive tract. The condition is sometimes called ileitis or enteritis.

Crohn's Disease Symptoms

The most common signs are pain in the stomach area (usually on the right side) and diarrhea. Others include rectal bleeding, weight loss and fever. Bleeding may be serious and lead to anemia. Children with Crohn's disease may experience delayed or stunted growth.

Causes and Risk Factors

Although the exact cause of Crohn's disease is unknown, many professionals believe that the body's immune system reacts to a virus or certain type of bacteria, which results in inflammation. People with Crohn's tend to have abnormal immune systems, but doctors do not know whether these problems are a cause or a result of the disease.

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The disease affects men and women equally and seems to run in some families. About 20% of patients with Crohn's disease have a blood relative with some form of IBD, usually a brother or sister, parent or child. Crohn's disease in not caused by emotional stress.

Diagnosis

A thorough physical exam and a series of tests may be needed to confirm Crohn's disease. Blood tests can check for anemia (a sign of bleeding in the intestines) or a high white blood cell count (indicating inflammation in the body). A stool sample can reveal bleeding or infection in the intestines.

A patient may undergo an upper gastrointestinal (GI) series, which involves drinking barium (a chalky solution that coats the lining of the intestine) before X-rays are taken to expose inflammation or other problems. A colonoscopy (a long, lighted tube linked to a computer monitor) may be inserted into the anus to look for signs of bleeding or swelling inside of the large intestine. A biopsy may be performed during a colonoscopy to remove a sample of tissue from the lining of the intestine for inspection under a microscope.

Possible Complications

Patients with Crohn's disease may have these complications:

  • The most common complication is blockage of the intestine, which occurs because the intestinal wall tends to get thick with swelling and scar tissue, causing the passageway to become narrower.
  • Sores or ulcers may tunnel past the affected area and get into nearby areas, such as the bladder, vagina, rectum or skin around the anus. These passageways are called fistulas and can become infected. Usually they can be treated with medicine, but sometimes surgery is needed to remove them.
  • Poor nutrition is common among IBD patients. Too little protein, calories and vitamins may result from not eating enough food, intestinal loss of protein or poor absorption of food and nutrients.
Other complications include arthritis, skin problems, inflammation of the eyes and mouth, kidney stones, gallstones or other diseases of the liver and biliary (ductal) system. Some of these problems can be addressed during treatment for Crohn's disease, while others may need to be treated separately.

Treatment

At this time, treatment can control Crohn's disease but not cure it. Treatment depends on the location, severity, complications and response to earlier treatment. The goal of the Cedars-Sinai Inflammatory Bowel Disease (IBD) Center is to control inflammation, correct nutrition problems and relieve symptoms of pain, diarrhea and rectal bleeding.

Crohn's disease usually appears several times randomly over the course of a person's lifetime, but some patients have long periods (sometimes years) when the symptoms go away. This diversity makes knowing if treatment helped or not difficult. Patients may need medical care for a long time, including regular visits to the doctor's office.

Treatment options include:

  • Medication
  • Nutrition supplements
  • Surgery
 
 
 
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