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Recent News and Articles on the Keywords: bone + tumors + tumor  Related to the article below (Last Update: 8/5/2008)

New Research Results Explain How Dormant Tumor Cells Become Active ...
Media Newswire (press release), NY -
Scientists using a three-dimensional cell culture system have identified a mechanism by which dormant, metastatic tumor cells can begin growing again after ...
Library section dedicated for Aliso Viejo's Hudson Wyss, 3, who ...
OCRegister, CA -
After battling most of his life with a rare malignant brain tumor, Hudson, died June 16. In a cruel twist, his sister, Abella, was diagnosed with the same ...
For the men who develop prostate cancer, early testing can improve ...
Orlando Sentinel, FL - 41 minutes ago
"When you start to have symptoms, such as bleeding and bone pain, it's too late to provide a cure with surgery or conservative treatment," says Dr. Vipul ...
Craig W. Philips Takes Helm at CTI
MarketWatch -
... demonstrated activity in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical, experimental tumor models. ...
Craig W. Philips Takes Helm at CTI Trading Markets (press release)
all 9 news articles »  CTIC - OTC:CMTX
SuperGen Reports 2008 Second Quarter Financial Results
MSN Money -
Highlights of the presentations are included below: -- SGI-1776, our lead pre-clinical PIM kinase inhibitor, was found to cause tumor regression in acute ...SUPG
Three-year-old survives rare cancer
Monessen Valley Independent, PA - Aug 2, 2008
Jakacki, a pediatric neuro-oncologist at Children's Hospital in Pittsburgh who treated Isabella, said rarer still is that the girl's tumor was isolated to ...

TopNews
Strong Bones Linked to Breast Cancer
U.S. News & World Report, DC - Jul 28, 2008
At first blush, that seems to put women in a bind: tumor if you do, fracture if you don't. The temptation to punch a wall in frustration is totally ...
BMD Plus Gail Score May Help Predict Risk for Postmenopausal ... Medscape (subscription)
all 54 news articles »

Business Wire (press release)
Hollis-Eden Pharmaceuticals Commences Phase I/II Clinical Trial ...
Business Wire (press release), CA - Jul 30, 2008
The study was designed to see if APOPTONE could kill castrate-resistant prostate tumor cells transplanted directly to the bone of experimental animals. ...
ARIAD Announces Start of Phase 2 Clinical Trial of Oral ... MarketWatch
GTx Announces Phase III Clinical Development Of Toremifene 20 Mg ... Medical News Today (press release)
all 19 news articles »  GTXI - HEPH

New York Times
The Doctor?s World The Story Behind Kennedy?s Surgery
New York Times, United States - Jul 29, 2008
What is known is that a few days after Mr. Kennedy learned he had a malignant brain tumor in the left parietal lobe, he invited a group of national experts ...
You and Your Health
Nigerian Tribune, Nigeria - Aug 1, 2008
A cancer or a tumor is an abnormal body growth caused when body cells multiply uncontrollably, destroying healthy tissue. Cancer of the kidney is a ...
Source: Google News

Bone tumors: clinical, radiologic, and pahtologic correlations
JM MIRRA, P PICCI, RH GOLD, AM GOORIN - Journal of the National Cancer Institute, 1990 - cat.inist.fr
Bone tumors: clinical, radiologic, and pahtologic correlations. ... of the National Cancer
Institute 82:1111 ... Tumeur maligne; Malignant tumor; Tumor maligno; Critique ...

Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens -
AY Huang, P Golumbek, M Ahmadzadeh, E Jaffee, D … - Science, 1994 - sciencemag.org
... Many tumors express tumor-specific antigens capable of being presented ... Rather, tumor
antigens were exclusively presented by host bone marrow-derived ...

… recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor -
D Lyden, K Hattori, S Dias, C Costa, P Blaikie, L … - Nat Med, 2001 - palgrave-journals.com
... of a blood vessel in a day 14 B6RV2 tumor (n = 12 ... Nearly all vessels were LacZ +
in D14 B6RV2 tumors growing in ... in h and i (insets) BM cells (eosin for bone). ...

Bone tumors: Diagnosis, treatment and prognosis
AG Huvos - Philadelphia, WB Saunders, 1979 - osti.gov
... approaches to treatment for each tumor type and also covers benign and malignant
bone-forming and cartilage-forming tumors, tumors of connective tissue origin ...

Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with … -
… TM Perl, S Nasraway, H Levy, R Bone, RP Wenzel, R … - JAMA, 1995 - Am Med Assoc
... H. Silverman, TM Perl, S. Nasraway, H. Levy, R. Bone, RP Wenzel ... To evaluate the efficacy
and safety of anti-tumor necrosis factor ... Mol Cancer Ther 2005;4:578-586 ...

Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia -
AR Perez-Atayde, SE Sallan, U Tedrow, S Connors, E … - American Journal of Pathology, 1997 - ASIP
... It has been shown that solid tumors progress in concert with an induction of tumor
angiogenesis. ... by factor VIII staining of bone marrow biopsies and ...

Giant-cell tumor of bone -
M Campanacci - The Journal of Bone and Joint Surgery, 1987 - JBJS
... The tumor on occasion invaded the articular space, also ... Extension to an adjacent
bone through the joint occurred in 5 per cent of the tumors. ...

… with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors -
DM Ashley, B Faiola, S Nair, LP Hale, DD Bigner, E … - Journal of Experimental Medicine, 1997 - Rockefeller Univ Press
... REPORT: Bone Marrow-generated Dendritic Cells Pulsed with Tumor Extracts or Tumor
RNA Induce Antitumor Immunity against Central Nervous System Tumors. ...

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by … -
M Gerhard, H Juhl, H Kalthoff, HW Schreiber, C … - Journal of Clinical Oncology, 1994 - jco.ascopubs.org
... and K. PANTEL RT-PCR-Based Detection of Occult Disseminated Tumor Cells in Peripheral
Blood and Bone Marrow of Patients with Solid Tumors: An Overview Ann. ...

Micrometastatic Breast Cancer Cells in Bone Marrow at Primary Surgery: Prognostic Value in … -
IJ Diel, M Kaufmann, SD Costa, R Holle, G von … - jnci, 1996 - jnci.oxfordjournals.org
... Tumor cells were detected in the bone marrow of ... TCD was associated with larger tumors
(P<.001), lymph node involvement (P = .001), and higher tumor grade (ie ...

Source: Google Scholar
 

Bone Tumors (Benign)

Most bone tumors are benign, and unlikely to spread. They can occur in any bone, but they usually are found in the biggest ones. These include the thighbone (femur), shinbone (tibia), upper arm bone (humerus) and pelvis. Some types are more common in specific places such as the spine or near the growth plates of the largest bones.

There are many specific types of tumors within the category of benign bone tumors. The most common ones are endochondromas, osteochondromas, nonossifying fibromas, chondroblastomas, osteoid osteomas, osteoblastomas, periosteal chondromas, giant cell tumors and chondromyxoid fibromas. Some conditions such as
aneurysmal bone cyst, unicameral bone cyst and fibrous dysplasia are grouped with benign bone tumors. They often are treated in a similar way, although they aren't truly tumors.

Article continues below and (thank you)

 
Symptoms of Benign Bone Tumors

A lump or swelling can be the first sign of a benign tumor. Another is ongoing or increasing aching or pain in the region of the tumor. Sometimes tumors are found only after a fracture occurs where the bone has been weakened by the growing tumor.

Causes and Risk Factors of Benign Bone Tumors

Benign bone tumors occur most often in children whose skeletons are still growing and people up to age 30. These tumors are often strongly affected by the hormones that cause growth. Many benign tumors stop growing once a child's bones do. This usually is between the ages 14 to 16 in girls and 16 to 19 in boys.

Treatment of Benign Bone Tumors

The type of tumor, its size, its location and how old the individual is all affect treatment decisions. Some tumors will heal after a fracture. Others may stop growing if the patient is near maturity when the tumor is discovered. Still other tumors are only discovered when an X-ray is taken for another reason. These may only need to be watched to make sure they aren't growing or becoming aggressive.

Usually, however, surgery is needed. Surgery removes the tumor and rebuilds new, healthy bone where the tumor was removed. At the Cedars-Sinai Orthopedic Center, specialized, minimally invasive techniques are used to protect the surrounding healthy tissue. This gives young patients the greatest chance of returning to full and unlimited activities.

Benign bone tumors include:

  • Osteoblastomas, which affect children and adolescents. These tumors can be large, aggressive and painful. They are best treated by a multidisciplinary team of oncologists, orthopedic surgeons and pain management specialists. They sometimes cause spinal deformity and paralysis. Treatment of depends on the tumor's size and location.

  • Osteoid osteoma, which is a small bone tumor (smaller than two centimeters). It usually affects adolescents, causing pain at night. It may also result in spinal deformity. Treatment depends the tumor's size and location. Surgery may be necessary if spine stability is compromised.
 

Bone Tumors (Malignant)

Malignant (cancerous) tumors are more rare than benign tumors - and more dangerous. The term malignant means there is moderate to high probability the tumor will spread beyond where it first develops. The cancer cells spread by traveling in the blood or through the lymph vessels. Malignant bone tumors most commonly spread to the lungs or to other bones.

In the past 15 years, dramatic improvements have been made in treating malignant bone tumors. There has been an increase of five to 10 times in the likelihood of a cure for high-grade osteosarcoma, the most common malignant bone tumor. Today the chance of a cure is approaching 80%. In addition, the combination of better surgical techniques and better ways to reconstruct function after surgery now means patients lead fuller, more active lives after surgery. Spinal tumors can be treated with stereotactic systems similar to brain surgery. Newly designed prosthesis allow for more than 90% of the limb to be saved with surgery. The orthopedic surgeons at Cedars-Sinai are specialists in this surgery.

Malignant bone tumors can occur at almost any age. Osteosarcoma and
Ewing's sarcoma, two of the most common malignant bone tumors, are usually found in people age 30 or younger. In contrast, chondrosarcoma, , malignant tumors that grow as cartilage-like tissue, usually occur after the age of 30.

In all cases, the best treatment requires a thorough evaluation by an experienced doctor. Optimal treatment demands the combined skills of an exceptional surgeon, pathologist, radiologist, radiotherapist, medical oncologist and sometimes a plastic surgeon.

Malignant bone tumors include:

  • Chondrosarcoma
  • Chordoma
  • Ewing's sarcoma
  • Neuroblastoma
  • Osteosarcoma
 
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