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Recent News and Articles on the Keywords: hypersensitivity pneumonitis: + pneumonitis + hypersensitivity  Related to the article below (Last Update: 8/5/2008)

Top-Line Results of Boceprevir Phase II Study Showed High Rate of ... CNNMoney.com (press release) - PEGINTRON is contraindicated in patients with hypersensitivity to PEGINTRON or any other component of the product, autoimmune hepatitis, ...SGP FDA Advisory Committee Provides Opinion of DORIBAX(TM) for the ... MarketWatch - Jul 16, 2008 When DORIBAX has been used investigationally via inhalation, pneumonitis has occurred. DORIBAX should not be administered by this route. ... Midwestern Floods Leave Toxins Behind Daily Green - Jul 8, 2008 Hypersensitivity Pneumonitis: Hypersensitivity pneumonitis may develop following either short-term (acute) or long-term (chronic) exposure to molds. ... Alkermes Announces Approval of VIVITROL ? for the Treatment of ... Business Wire (press release), CA - Consider the diagnosis of eosinophilic pneumonia if patients develop progressive dyspnea and hypoxemia. Injection site reactions not improving may require ...ALKS - JNJ Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III ... FOXBusiness - Jul 11, 2008 PEGINTRON(TM) is contraindicated in patients with hypersensitivity to PEGINTRON(TM) or any other component of the product, autoimmune hepatitis, ...SGP - SGP-B - OTC:CMTX Microbial Solutions Scoops Ford Engineering Excellence Award For ... Medical News Today (press release), UK - Jul 8, 2008 ... metalworking fluids and has been linked to hypersensitivity pneumonitis, a serious respiratory illness affecting workers in the machining industry. ... Tobacco: What Is It and Why Do People Continue to Use It? RedOrbit, TX - Jul 27, 2008 Animal models have shown that once these receptors become sensitized to nicotine, they will remain hypersensitive to the psychomotor activating effects of ... Investigation of Mycobacterium Tuberculosis Transmission Aboard ... RedOrbit, TX - Jul 15, 2008 He was diagnosed with communityacquired pneumonia, treated with a fluoroquinolone antibi-. otic, and restricted for 1 week to his berthing compartment ...

Hypersensitivity Pneumonitis

Hypersensitivity pneumonitis is an allergic reaction that causes inflammation (swelling and tenderness) in and around the air sacs (alveoli) of the lungs and the smallest airways (bronchioles).

Dust, tiny organisms or chemicals can cause the allergic reaction. Not everyone exposed to these materials develops an allergic reaction. It usually takes exposure to large amounts of these materials (allergens) frequently over a period of time before a sensitivity and reaction develop. Only a small percentage of those who develop allergic reactions suffer permanent damage to the lungs.

In the most serious cases the combination of the allergic reaction and the immune system's reactions can cause lung damage. With more and more exposure, the immune system reacts against the allergic reaction, causing chronic inflammation. The inflammation is a result of white blood cells building up in the walls of the alveoli and bronchioles. As the buildup increases, symptoms increase and damage to the lungs grows.

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Once a person has developed hypersensitivity to a material or organism, he or she may experience symptoms the next time exposure occurs. These symptoms usually develop in four to eight hours and include:

• Fever
• Cough
• Chills
• Shortness of breath

In one form of hypersensitivity pneumonitis, a cough and shortness of breath may take days or weeks to develop and be so severe that the person needs to be hospitalized. If a person is repeatedly in contact with an allergen over months or years, the lungs may become scarred (fibrosis). Symptoms in this case may include shortness of breath during exercise, coughing up of sputum, tiredness and a gradual weight loss. Eventually, respiratory failure can occur.

Many types of dust, organisms or chemicals can cause allergic reactions in the lungs, including:

• Heat-loving bacteria in moldy hay
• Contamination in humidifiers or air conditions (especially large systems in office buildings)
• Chemicals, such as urethanes (isocyanates)
• Wood dust
• Droppings from poultry or other birds
• Chemicals used in making polyrethane foam, molding, insulation, synthetic rubber and packaging materials
• Materials found in certain types of farming or food production or processing, including mushroom compost, moldy cork, infected maple bark, moldy barley or malt, cheese mold, sugar cane, unroasted coffee beans or weevil-infested wheat flour

Diagnosing hypersensitivity pneumonitis depends on the symptoms, identifying (if possible) the cause of the reaction and showing the person's exposure to the suspected agent.

In addition to a physical examination a doctor may order the following tests:

• Blood test to see if antibodies are present showing an immune system response to an allergen
• Chest X-ray. In some cases, an abnormal finding on an X-ray done for another reason may uncover the lung damage caused by hypersensitivity pneumonitis.
• Tests to measure the lungs' ability to hold and move air and to exchange oxygen and carbon dioxide

Avoiding exposure to dust or chemicals is important. If a person cannot change jobs, he or she should wear a protective masks and work in a well-ventilated place, if possible.

After an acute episode of hypersensitivity pneumonitis, a person can usually recover without treatment if he or she has no more contact with the allergen. In serious cases, it may be necessary to use corticosteroids, such as prednisone, to lessen the symptoms and reduce inflammation in the lungs. If episodes go on for a long period of time or come back often, a person may suffer permanent lung damage and growing difficulty with breathing (dyspnea).