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Recent News and Articles on the Keywords: blood + kidney + pressure  Related to the article below (Last Update: 8/5/2008)


Dividend.com
Single-Pill Combinations Diovan HCT and Exforge Approved in US as ...
MarketWatch - Aug 3, 2008
If left untreated, patients with high blood pressure are at risk of cardiovascular events, such as stroke, heart attack and heart failure, as well as kidney ...
Single-pill combinations Diovan HCT? and Exforge? approved in US ... Prdomain Business Register (press release)
Novartis says FDA OKs Diovan HCT and Exforge Single-Pill ... RTT News
all 35 news articles »  NVS
Medicines Receives FDA Approval To Market IV Blood Pressure Drug ...
RTT News, NY -
It is the first non-pill drug to receive approval for high blood pressure in 10 years, the company noted. Medicines Co. said Cleviprex is metabolized in the ...
Medicines Co. gets lift from drug approval The Star-Ledger - NJ.com
FDA OKs Medicines Co.'s Cleviprex (Update) TheStreet.com
The Medicines Company?s Cleviprex? Receives FDA Approval Business Wire (press release)
all 36 news articles »  MDCO
Hypertension is normal in south Louisiana, but it can be corrected
Houma Courier, Louisiana -
This is called systole (the high number in a blood pressure reading). Next, your heart will relax to allow more blood to fill the heart for the next beat. ...
Picture project helps MetroHealth patients reduce blood pressure
The Plain Dealer - cleveland.com, OH - 10 minutes ago
High blood pressure or hypertension leads to heart disease, stroke and kidney disease; 25 percent of Americans have it; many of them are black, ...
10 Warning Signs You Might Have Kidney Disease
MarketWatch -
"With so many people already diagnosed with conditions that can lead to kidney disease, such as diabetes and high blood pressure, educating the community is ...
Metabolic syndrome: An epidemic of the deadly quartet
Staten Island Advance - SILive.com, NY -
Elevated insulin levels also increase the reabsorption of salt and water by the kidney, and this retained fluid tends to increase blood pressure. ...
Alex "Iron Doc" McDonald: Water and Salt: Separate but Equal
Xtri.com -
It is true that those individual with high blood pressure, kidney or cardiac problems as well as some other medical conditions need to avoid sodium. ...
PAHO Rep. Highlights Chilling Effects of Non-Communicable Diseases
Government of Jamaica, Jamaica Information Service, Jamaica -
Dr. Samuels points out that the higher a person's blood pressure, the greater the chance of a heart attack, heart failure, stroke or kidney disease. ...
Natural Sources of Potassium Can Lower High Blood Pressure
Fitcommerce - Aug 3, 2008
Low potassium intake is thought to contribute to the prevalence of high blood pressure in Americans. Based on their review of published studies on the topic ...
Sorting Out Coffee?s Contradictions
New York Times, United States -
Heart patients, especially those with high blood pressure, are often told to avoid caffeine, a known stimulant. But an analysis of 10 studies of more than ...
Source: Google News

… the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure … -
MJ Sarnak, AS Levey, AC Schoolwerth, J Coresh, B … - Hypertension, 2003 - Am Heart Assoc
... A Statement From the American Heart Association Councils on Kidney in Cardiovascular
Disease, High Blood Pressure Research, Clinical Cardiology, and ...

Association of chronic kidney graft failure with recipient blood pressure. -
G Opelz, T Wujciak, E Ritz - Kidney International, 1998 - pt.wkhealth.com
... Context Link]. 10. Brazy PC, Stead WW, Fitzwilliam JF: Progression of renal
insufficiency: Role of blood pressure. Kidney Int 35:670-674, 1989 [Context Link]. ...

… of Blood Pressure Lowering and Antihypertensive Drug Class on Progression of Hypertensive Kidney … -
JT Wright, Jr, G Bakris, T Greene, LY Agodoa, LJ … - JAMA, 2002 - Am Med Assoc
... Effect of Blood Pressure Lowering and Antihypertensive Drug Class on Progression
of Hypertensive Kidney Disease Results From the AASK Trial. ...

Blood pressure control--special role of the kidneys and body fluids -
AC Guyton - Science, 1991 - sciencemag.org
... Hypertension 35: 699-703 | Abstract ? | Full Text ? | PDF ? Antihypertensive
Effect of 0.1-Hz Blood Pressure Oscillations to the Kidney. ...

Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and … -
TH Jafar, PC Stark, CH Schmid, M Landa, G Maschio, … - Annals of Internal Medicine, 2003 - annals.highwire.org
... Thus, the observed relationship between current blood pressure and kidney disease
progression might reflect "reverse causation" (more severe kidney disease ...

Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive …
G Bianchi, U Fox, GF Di Francesco, AM Giovanetti, … - Clin Sci Mol Med, 1974 - ncbi.nlm.nih.gov
1974 Nov;47(5):435-48. Blood pressure changes produced by kidney cross-transplantation
between spontaneously hypertensive rats and normotensive rats. ...

… with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and … -
GL Bakris, M Williams, L Dworkin, WJ Elliott, M … - Am J Kidney Dis, 2000 - ncbi.nlm.nih.gov
... National Kidney Foundation Hypertension and Diabetes Executive Committees Working
Group ... of clinical trial data has affirmed the original blood pressure goal of ...

Reactive oxygen species: Roles in blood pressure and kidney function -
CS Wilcox - Current Hypertension Reports, 2002 - Springer
Page 1. Reactive Oxygen Species: Roles in Blood Pressure and Kidney Function
Christopher S. Wilcox, MD, PhD Address Division of Nephrology ...

[CITATION] African American Study of Kidney Disease and Hypertension Study Group. Effect of blood pressure …
JT Wright Jr, G Bakris, T Greene, LY Agodoa, LJ … - JAMA, 2002

Progression of renal insufficiency: role of blood pressure -
PC Brazy, WW Stead, JF Fitzwilliam - Kidney Int, 1989 - nature.com
... Debrevi L, Cubela R, Whitly M, Johnston CI: Preservation of renal function in the
rat remnant kidney model of chronic renal failure by blood pressure reduction ...

Source: Google Scholar
 

While men and women both get high blood pressure and related kidney disease, the path to get there is shorter, steeper and just different for men, researchers say.

"They may end up at the same point, but the way they got there could be very different," says Dr. Jennifer C. Sullivan, pharmacologist/physiologist at the Medical College of Georgia Vascular Biology Center.

"It's known that men tend to develop hypertension earlier than women and the increase in blood pressure occurs more rapidly than it does in women, until they hit menopause. I look at our spontaneously hypertensive rats and see the same dichotomy in blood pressure," Dr. Sullivan says of the animal model she studies. "There are also differences in development of renal injury in the human population and chronic renal disease seems to be worse in men and I see the same thing in my animal model."

She's looking at these gender differences to find what protects females, at least for much of their life, work that led to her selection for the 2007 New Investigator Award of the American Physiological Society's Water and Electrolyte Homeostasis Section. She presented her work during the Experimental Biology Meeting Annual Meeting in Washington, D.C.

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Female hormones can't account for all the difference, she says. "It's not that easy. Men and women are more than just sex hormones." When she takes testicles out, for example, blood pressure and injury incidence drop some; when she takes ovaries out, blood pressure remains unchanged but kidney injury increases slightly. "There are fundamental differences, I believe, in the physiology. They are going to end up at the same point but the way there could be very different."

So she's comparing in males and females some major players in blood pressure regulation and renal injury: the potential for blood vessels to relax and constrict and the amount of damage-producing free radicals.

She's finding that nitric oxide synthase, which makes nitric oxide, a signaling molecule that tells smooth muscles cells to relax, may make more nitric oxide in females. Just how active an enzyme is depends on how it's phosphorylized, or turned on by adding phosphate groups. "Our preliminary data says that the phosphorylation status may increase nitric oxide production - and maintain kidney health - in females," Dr. Sullivan says.

In contrast is the powerful constrictor of blood vessels, angiotensin 2. In the outer most part of their kidneys, males have a lot of the AT1 receptors that enables angiotensin 2 to do harm. "It's a vasoconstrictor when it binds with AT1," she says. "It will cause proliferation, it will cause hypertrophy, it can stimulate the production of reactive oxygen species, so it does all sorts of bad things," she says.

Fortunately there are already drugs that block angiotensin 2's destructive action: angiotensin receptor blockers and ace inhibitors. Interestingly, clinical studies already have shown these drugs don't work as well in women. "A lot of women are on these drugs too and I'm not sure it's doing them a lot of good," she says. One of her goals is to find out.

When she looks in the outer most part of the kidney, called the renal cortex, she also finds males have too many highly reactive and potentially damaging free radicals. Free radicals or reactive oxygen species have important jobs in the body, like cell signaling, but as with anything, it's all about balance.

When there are too many, it creates oxidative stress, a contributor to most major diseases, such as cancer and cardiovascular disease, as well as aging in general. In high blood pressure, free radicals damage proteins critical to blood vessels and the kidneys.

The body has natural mechanisms for keeping free radicals in check, including endogenous antioxidants. "But if you get increases, it can overwhelm the natural ability of the body to take care of it," she says.

When she looks to see the toll all this takes on the kidneys, she finds about a 50 percent increase in the amount of protein excreted in the urine - a sure sign of kidney disease - in the males.

She notes that by age 70, the rates of cardiovascular disease and hypertension are similar in men and women and that older women tend to have higher blood pressures than age-matched men.
 
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