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Recent News and Articles on the Keywords: 0.31 + heart + decline  Related to the article below (Last Update: 8/5/2008)

Cambridge Bancorp Reports Solid Second Quarter Results
Trading Markets (press release), CA - Jul 22, 2008
Non-performing loans as a percentage of total loans stood at 0.23% at June 30, 2008, a decline from 0.27% at December 31, 2007. Loan quality remains strong ...OTC:CATC
08 CLARITY in numbers ANNUAL REPORT & ACCOUNTS 2008
Sydney Morning Herald, Australia - Jul 6, 2008
This represents In consumer finance, the balance of (2007: 0.31%) and for prime residential only 1.41% (2007: 1.43%) of the total accounts more than 30 days ...

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… with a sustained decline in brain natriuretic peptide levels in patients with congestive heart … -
RP Frantz, LJ Olson, D Grill, SK Moualla, SM … - American Heart Journal, 2005 - Elsevier
... change in LVEF was seen (r = -0.31, P = .08 ... NANP levels decline more gradually than
BNP levels after ... peptide levels in monitoring patients with heart failure. ...

Diminished nocturnal decline in blood pressure in elderly hypertensive patients with left … -
I Kuwajima, Y Suzuki, T Shimosawa, A Kanemaru, S … - Am Heart J, 1992 - ncbi.nlm.nih.gov
Am Heart J. 1992 May;123(5):1307-11 ... Click here to read Diminished nocturnal decline
in blood pressure in ... ns) or the SBP after handgrip exercise (r = 0.31, p = ns ...

Functional decline after congestive heart failure and acute myocardial infarction and the impact of … -
G Kempen, R Sanderman, I Miedema, B Meyboom-de … - Quality of Life Research, 2000 - Springer
... Key words: Acute myocardial infarction, Congestive heart failure, Functional decline,
Mastery, Neuroti- cism, Self-e?cacy expectancies Introduction ...

Socioeconomic inequalities in mobility decline in chronic disease groups (asthma/COPD, heart disease … -
A Koster, H Bosma, GIJM Kempen, FJ van Lenthe, JTM … - British Medical Journal, 2004 - jech.bmj.com
... 0.31 to 2.13 ... chronic diseases were over-represented: asthma/COPD, heart disease,
diabetes ... OR) and 95% confidence intervals (95% CI) for decline in mobility by ...

The effect of age on heart rate in subjects free of heart disease. Studies by ambulatory … -
JB Kostis, AE Moreyra, MT Amendo, J Di Pietro, N … - Circulation, 1982 - Am Heart Assoc
Page 1. ISSN: 1524-4539 Copyright ? 1982 American Heart Association. ... Page 2. The
Effect of Age on Heart Rate in Subjects Free of Heart Disease ...

… BEHAVIORS RELATED TO THE PREVENTION AND TREATMENT OF CORONORY HEART DISEASE: THE SAN ANTONIO HEART … -
HP HAZUDA, MP STERN, SP GASKILL, SM HAFFNER, LI … - American Journal of Epidemiology, 1983 - Oxford Univ Press
... Since the find- ing that the rate of decline in coronary ... 0.44 ? 0.04 0.31 ? 0.03 ...
Age-adjusted scores for behavior related to prevention of heart attacks (IND ...

Time Course of Heart Rate Variability Decline Following Particulate Matter Exposures in an … -
JM Cavallari - Inhalation Toxicology, 2008 - informaworld.com
... 2 48 -5.33 e (-10.97, 0.31) -3.21 (-8.78 ... abrief,yetsta- tistically significant,
decline in SDNN ... Using heart rate rather than HRV, studies demonstrate a ...

Effects of acidosis and ischemia on contractility and intracellular pH of rat heart -
C Steenbergen, G Deleeuw, T Rich, JR Williamson - Circulation Research, 1977 - Am Heart Assoc
... The decreased contractile activity of the heart induced by acidosis indicates a
decline in energy ... 0.01 ? 0.02 -0.24 ? 0.03 0.08 ? 0.02 -0.31 ? 0.03 ...

Exercise training restores ischemic preconditioning in the aging heart -
P Abete, C Calabrese, N Ferrara, A Cioppa, P … - Journal of the American College of Cardiology, 2000 - Am Coll Cardio Found
... 0.09 pmol/ml/g in adult hearts, 0.31 ? 0.05 to ... some endogenous protective mechanisms
against coronary heart disease that decline with advancing age. ...

… energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary … -
JR Benotti, W Grossman, E Braunwald, BA Carabello - Circulation, 1980 - Am Heart Assoc
... changes occurred in aortic mean pressure, heart rate, myocardial lactate extraction
or ECG, and no patient developed angina. In explaining the decline in MVO2 ...

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Some heart drugs may slow mental decline with age

Last Updated: 2007-05-07 13:00:10 -0400 (Reuters Health)

By Anne Harding

NEW YORK (Reuters Health) - Older people who take certain blood pressure-lowering drugs may also be protecting themselves from declines in memory and other brain function, research suggests.

The drugs that researchers believe are protective are part of a class known as ACE inhibitors -- specifically those types that enter the brain and may help curb inflammation that might contribute to dementia.

Article continues below and (thank you)
 

The study found a link between taking these "centrally acting" ACE inhibitors and lower rates of mental decline as measured by the Modified Mini-Mental State Exam, a test that evaluates memory, language, and other cognitive functions.

For each year that subjects were exposed to centrally acting ACE inhibitors that enter the brain, the decline in test results was 50 percent lower than the decline in people taking other kinds of high blood pressure pills.
 

While the actual difference was small, "after a few years of being on the drug, I'd say it's a relevant difference," Dr. Kaycee Sink of Wake Forest University School of Medicine in Winston-Salem, North Carolina told Reuters Health.

Centrally acting ACE inhibitors include captopril (Capoten), fosinopril (Monopril), lisinopril (Prinivil or Zestril), perindopril (Aceon), ramipril (Altace) and trandolapril (Mavik).

Sink decided to investigate the effect of centrally acting ACE inhibitors on dementia risk after her Wake Forest colleagues found the drugs protected rats from brain injury due to radiation. She presented her findings May 5 at the American Geriatrics Society's annual meeting in Seattle.

She and her colleagues looked at a subgroup of 1,074 men and women participating in a study of cardiovascular health who were taking drugs to treat hypertension and were dementia-free when the study began.

While the centrally acting ACE inhibitors did slow cognitive decline, as Sink had hypothesized, the non-centrally active ACE inhibitors that don't reach the brain actually boosted the risk of developing dementia by 20 percent, although the effect didn't reach statistical significance.

The centrally acting ACE inhibitors could be protecting the brain by reducing inflammation, which has been implicated in Alzheimer's disease, or they might be increasing blood flow to the brain, Sink said.

If she had to take an ACE inhibitor, Sink said, she'd ask to be prescribed a centrally acting one. "There doesn't seem to be any downside, and they may be benefiting you."

However, a clinical trial in which people taking centrally acting ACE inhibitors and people taking different blood pressure drugs are followed to determine who develops dementia will be necessary to confirm the results, she added.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
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