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Recent News and Articles on the Keywords: paget's disease + paget's disease: + pagets  Related to the article below (Last Update: 8/5/2008)

IntroductionHyperprolacinemia is an uncommon cause of erectile ... 7thSpace Interactive (press release), NY - Jul 18, 2008 This case proposes a rare example of a causative link between the two and how treatment of the Paget's disease with bisphosphonates helped the patient ... Daily Mail Doctor, I've got a bone to pick with you... The bone problems that ... Daily Mail, UK - This can lead to problems such as osteoporosis, while Paget's disease causes the cells that make new bone to work too quickly, throwing down new cells even ... Influence of Musculoskeletal Conditions on Oral Health Among Older ... RedOrbit, TX - Jul 10, 2008 Several musculoskeletal diseases, including osteoporosis, Paget's disease, and arthritic disorders, may directly involve the oral cavity and contiguous ... EU agency backs use of Novartis bone drug in men Reuters - Jul 25, 2008 Aclasta is currently indicated for the treatment of osteoporosis in post-menopausal women at increased risk of fracture and treatment of Paget's disease of ...NVS EU Panel Backs GSK's Pre-Pandemic Influenza Vaccine CNNMoney.com - Jul 25, 2008 Aclasta is currently indicated for the treatment of osteoporosis in post-menopausal women at increased risk of fracture and treatment of Paget's disease of ... You ain't crazy, it might be chronic fatigue syndrome Frost Illustrated, IN - Jul 8, 2008 Paget's disease, named after Sir James Paget (1814-1899), is characterized by deformities of long bones and the skull, usually occurring in old age. ... UVA Cancer Researcher First to Receive Premier Research Grant WCAV, VA - Jul 23, 2008 The Bone and Cancer Foundation of New York, NY, is a program of the Paget Foundation for Paget's Disease of Bone and Related Disorders. ... Aclasta, Veclade get CHMP nods FiercePharma, DC - Jul 25, 2008 It's currently approved only for use in post-menopausal women and for treatment of Paget's disease. Johnson & Johnson's blood cancer med Velcade got a ... Dignitaries Pay Final Respects to Former Senator Helms Washington Post, United States - Jul 8, 2008 ... Convalescent Center in Raleigh after a battle with illnesses that included heart ailments, prostate cancer, Paget's disease and vascular dementia. ... Once-yearly Aclasta? Recommended In EU To Treat Male Osteoporosis ... ABN Newswire (press release), Australia - Jul 25, 2008 It is now approved in more than 70 countries, and in more than 80 countries for the treatment of Paget's disease of bone, the second most common metabolic ...

Paget's disease, also know as osteitis deformans, occurs when the normal process of bones being broken down and rebuilt goes awry. With Paget's disease, the bone breaks down more quickly. When it is rebuilt, it is softer than normal bone.

The disease can affect any bone but usually affects the spine, pelvis, skull, thighbone (femur) and shinbone (tibia). In addition, Paget's disease can lead to other conditions including osteoarthritis, kidney stones and heart disease.

Signs of Paget's disease include:

• Soft, porous bones that are weak and easily bend. This can lead to shortening of the body in the affected area.
• Build-up of too much bone. As the bone is quickly replaced with Paget's disease, extra bone is formed, causing bones to get larger, be painful and break easily.
• An abnormal increase in the blood vessels in the bone affected by Paget's disease. This causes the area may feel warmer than usual.

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it is not yet known what exactly causes Paget's disease. A slow-acting virus may be involved, although it hasn't been identified yet. There may be a genetic element. Some studies have shown that up to 30% of those with Paget's disease have family members who also have the condition. The disease is more common in areas where many people are of Anglo-Saxon descent.

Often, Paget's disease can be diagnosed after your doctor has taken your medical history and done a physical exam. An X-ray of the affected bones, bone scans and blood and urine tests can confirm the diagnosis and show what parts of the bone are affected. Paget's disease is sometimes discovered during the course of a physical exam for another problem. There may not be any symptoms at the time, but routine tests may indicate that Paget's disease is present.

The doctors at the Cedars-Sinai Orthopedic Center specialize in diagnosing Paget's disease. Having a rheumatologist or endocrinologist (or both) on your healthcare team can also be helpful. A rheumatologist is a doctor trained in diagnosing and treating problems with the joints, muscles and other parts of the body. An endocrinologist is trained in diagnosing and treating metabolic and hormonal disorders. These disorders affect how fast body systems work and grow.

There is no cure for Paget's disease yet. Treatment can, however, slow the rate of bone loss, build up new bone and lessen pain. Treatment of Pagets disease includes:

• Bisphosphonates including Didronel, Fosamax and Actonel help the body produce normal bone.
• Calcitonin helps relieve pain, slow bone loss and help growth.
• Pain relievers such as acetaminophen (Tylenol, Panadol, Exdol) or pain-relieving anti-inflammatory drugs such as aspirin can help. Anti-inflammatory drugs also help reduce swelling and stiffness.
• Calcium supplements (1,000 to 1,500 mg of calcium a day)
• Vitamin D supplements. Persons with Paget's disease should get at least 400 units of vitamin D a day. This helps the bone absorb calcium and grow. People with Paget's disease often have too little vitamin D in their bodies.

• Makes the muscles around a joint stronger. This protects it and preserves the range of motion.
• Helps maintain a healthy weight. That puts less strain on the body and bones.
  

A physical therapist can show you the best types of exercise to safely do when you have Paget's disease.

• Applying heat (such as taking a hot shower) helps relax aching muscles, reducing the pain and stiffness.
• Applying cold (such as an ice pack) reduces the pain and swelling.
  

• After doing heavy or repetitive work, stop and rest. Switch regularly from heavy work to slower paced, easier tasks. The different tasks use different muscles and joints.
• Use your back, arms and legs in safe ways to avoid putting stress on joints. For example, carry a heavy load close to your body or use devices such as a cart to carry your grocery bags.
  

People with severe Paget's disease may need surgery, especially if a joint is badly damaged. Surgery can be done to repair or rebuild parts of the bone, fix fractures or replace a joint. After surgery, a person with Paget's disease is able to move better and with less pain.