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Recent News and Articles on the Keywords: dna + heart + risk  Related to the article below (Last Update: 8/5/2008)


dBTechno
Discovery may boost statin safety
BBC News, UK - Jul 23, 2008
"A DNA test based on these findings could guide doctors as to whether a patient at high risk of heart disease will cope with a high dose of a statin, ...
Rare side effect of statins studied The Press Association
Gene May Predict Cholesterol-Lowering Drug Risk, Study Says Bloomberg
Statin study could lead to test for gene variant The Associated Press
U.S. News & World Report - Washington Post
all 228 news articles »  GENE
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Brostallicin, a novel synthetic second- generation DNA minor groove binder, has potent cancer killing activity and has demonstrated activity in combination ...CTIC - OTC:CMTX
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Two large, separate international studies published in the journal Nature found that specific DNA deletions increased a person's risk of the disease 12- to ...

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Ont. introduces guidelines for coroners, pathologists
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They could also point to inherited life-threatening heart defects that can strike surviving family members. "Every month, we see parents who have lost a ...
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This is an issue in several significant health concerns, ranging from heart disease to Alzheimer?s disease, premature aging and cancer. ...
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Zinc on the other hand is essential in the manufacture of DNA, which determines one?s characteristics. A deficiency of the two therefore leads to ...
Montreal Heart Institute researchers contribute to the discovery ...
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In order to complete this study, the researchers examined the more than 20000 genes in the human genome by performing over 300000 genetic tests of DNA ...

BBC News
Decoding me
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"This corresponds to a 44.2% lifetime risk of developing heart attack, which is 10% less than for males of European ancestry in general." So far so good, ...
Source: Google News

… in Two Paraoxonase Genes (PON1 and PON2) Are Associated with the Risk of Coronary Heart Disease -
DK Sanghera, CE Aston, N Saha, MI Kamboh - The American Journal of Human Genetics, 1998 - UChicago Press
... DNA Polymorphisms in Two Paraoxonase Genes (PON1 and PON2) Are Associated with the
Risk of Coronary Heart Disease. Dharambir K. Sanghera,. Christopher E. Aston, ...

… -Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study -
RK Mattu, EWA Needham, DJ Galton, E Frangos, AJL … - Circulation, 1995 - Am Heart Assoc
... subjects from the Caerphilly Prospective Heart Disease Study ... Amplification of genomic
DNA using the polymerase ... specified following multiple risk factor analysis ...

Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. -
T Katsuya, G Koike, TW Yee, N Sharpe, R Jackson, R … - Lancet, 1995 - ncbi.nlm.nih.gov
... we examined the associations with coronary heart disease (CHD) of ... Risk factors for
CHD were assessed by standard ... Genomic DNA from leucocytes was analysed for ...

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry -
K Bachmaier, N Neu, LM de la Maza, S Pal, A Hessel … - Science, 1999 - sciencemag.org
... peptide. Chlamydia DNA functioned as an adjuvant in the triggering of
peptide-induced inflammatory heart disease. Infection with ...

… artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human … -
FJ Van Schooten, A Hirvonen, LM Maas, BA De Mol, … - FASEB J, 1998 - ncbi.nlm.nih.gov
... for lung cancer in smokers, we explored for the first time whether the GST
polymorphisms could also explain deviating heart DNA adduct levels and CAD risk. ...

Circulating chlamydia pneumoniae DNA as a predictor of coronary artery disease -
Y Wong, KD Dawkins, ME Ward - Journal of the American College of Cardiology, 1999 - Am Coll Cardio Found
... Home page, J Am Coll Cardiol Home page D. Taylor-Robinson and BJ Thomas Coronary
heart disease and chlamydia pneumoniae DNA in blood mononuclear cells J. Am. ...

DNA variants at the LPL gene locus associate with angiographically defined severity of … -
RK Mattu, EW Needham, R Morgan, A Rees, AK … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1994 - Am Heart Assoc
... Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease :
A Meta ... page XL Wang, RM McCredie, and DEL Wilcken Common DNA Polymorphisms at ...

Diseases of the Mitochondrial DNA -
DC Wallace - Annual Reviews in Biochemistry, 1992 - Annual Reviews
... the central nervous system, muscle, heart, pancreatic islets ... in mtDNA than in nuclear
DNA (3, 5, 6 ... eliminated by selection, mitochondrial genetic disease must be ...

DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene -
DA Nickerson, SL Taylor, KM Weiss, AG Clark, RG … - Nature Genetics, 1998 - nature.com
... are participants in the Rochester Family Heart Study of cardiovascular risk and
risk factor variation ... were selected for this survey of DNA sequence variation ...

[PDF] A DNA polymorphism discovery resource for research on human genetic variation -
FS Collins, LD Brooks, A Chakravarti? - Genome Res, 1998 - udl.es
... This DNA Polymorphism Discovery Re- source will be ... the genes contrib- uting to the
risk of common diseases such as diabetes, heart disease, cancers, and ...
-

Source: Google Scholar
 

One in 5 Britons has DNA that can double risk of a heart attack

By FIONA MacRAE

Genes which can double the risk of having a heart attack have been discovered by scientists.

It is thought that one in five of us carries two copies of the rogue DNA sequence - dramatically increasing our chances of being affected.

The findings could lead to new ways of treating and even preventing a condition which claims the lives of more than 100,000 Britons each year.

The breakthrough, reported in the respected journal Science, comes just weeks after British scientists discovered an obesity gene.

It could lead to the development of a generation of drugs tailored to an individual's genetic make-up.

Article continues below and (thank you)

 

But there are also fears that insurance companies could cash in on the advances by hiking premiums for those at risk - or even refusing to insure them altogether.

The discovery also raises the possibility that DIY genetic testing kits could be produced - allowing individuals a glimpse into their future health.

The latest findings centre around two research projects which, for the first time, have identified a common DNA sequence which greatly increases the risk of heart disease.

In the first study, Icelandic scientists compared the genetic make-up of 1,600 men and women who had heart attacks with almost 7,000 healthy people. They

discovered a particular stretch of DNA which greatly increased the risk of heart attacks - a conclusion they confirmed by screening the genes of thousands of Americans.

As all genetic sequences come in pairs - one inherited from the mother, the other from the father - the one in five people who carry two copies of the rogue strand of DNA are at greatest risk.

They are twice as likely to have a heart attack while still comparatively young - before the age of 50 for men and 60 for women - and 64 per cent more likely to have a heart attack at any age.

Those with one copy of the mutation are almost 50 per cent more likely to suffer an "early onset" heart attack than those with "normal" DNA and 26 per cent more likely to have a heart attack at any time.

The researchers, from Reykjavik biotechnology firm deCODE, calculated that the flawed DNA is behind almost a third of heart attacks in youngsters and a fifth of heart attacks overall.

They plan to create a test which would allow doctors to pinpoint those who are genetically programmed to suffer heart attacks.

The second study, carried out independently from the first, also picked out the same piece of DNA.

However the Canadian researchers, from the University of Ottawa calculated the risks as being slightly lower than the first set of scientists did.

They estimated that inheriting the genetic flaw increases the risk of heart disease - and strokes - by up to 40 per cent.

While both groups of scientists zeroed in on the same piece of DNA, it is not clear whether it forms a single gene or is part of several genes.

Alternatively, it may control nearby genes which are involved in cell growth, aging and death - all processes which play a role in the health of our circulation.

Even though it is not clear what the rogue DNA actually does, its discovery could pave the way for ways of treating and even preventing heart disease.

It also raises the possibility of creating genetic kits to test for the problem DNA.

However, experts warn the results of such tests are likely to be of little use until we can also test for other - as yet undiscovered - genes linked

to heart disease. Dr Helen Wallace, of watchdog GeneWatch UK, said genetic testing could give people the wrong impression about their chances of developing a disease.

She added that lack of regulation means companies could make also false claims about testing kits.

Experts stressed that while our genes are undoubtedly important in cardiac health, other factors such as smoking, poor diet and a lack of exercise play a much greater role in causing heart attacks.

Dr Tim Chico, a consultant cardiologist at Sheffield University, urged everyone to take control of their own health.

He said: "We must not forget that 90 per cent of the risk of heart attack comes from things like smoking, cholesterol, diet, lack of exercise and diabetes.

"The worst thing would be to think 'I haven't got this, so I'm safe', or 'I've got this, so I'm doomed'."

"The effect of smoking is double the effect of having this gene. If you smoke and are overweight and don't take enough exercise, that swamps the effect of your genes.

"Whatever our genetic make-up, we can all reduce our chances of heart disease by improving our lifestyle."

The breakthrough comes just weeks after scientists at Oxford University and the Peninsula Medical School in Exeter discovered an obesity gene.

The study revealed that the genetic make-up of one in six Britons increases their chance of becoming dangerously overweight by 70 per cent.

 
 
 
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