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Recent News and Articles on the Keywords: to treat + hamilton college + new  Related to the article below (Last Update: 7/8/2008)


Boston Globe
A Neponset Valley high note: Classical gets closer to home
Boston Globe, United States - Jul 6, 2008
The Long Island native studied at Northwestern University and has been a lifelong trombone player, having performed with the Hamilton Philharmonic in Canada ...
New Blood Clot Guidelines For Pregnant Women
Science Daily (press release) - Jun 24, 2008
Antithrombotic and thrombolytic therapies are used to prevent and treat thrombosis or blood clotting that arises in arteries, veins, and the heart. The new ...

FOXSports.com
Limbaugh's not that different from pro jocks
FOXSports.com - Jul 3, 2008
Limbaugh, 57, is dating a 31-year-old blonde party planner, Kathryn Rogers, who is a treat to admire. At first glance, she could pass for the little sister ...
Comprehensive Thrombosis Guidelines Published
Medscape (subscription) - Jul 1, 2008
Describe new evidence-based American College of Chest Physicians recommendations to prevent and treat thrombosis in pregnant women and children. ...
Professionals brainstorm on how to better prevent and treat depression
Chadron Record, NE - Jun 24, 2008
NET Television aired the conference at four sites across the state, including Chadron State College. The seminar allowed professionals and other individuals ...

CoStar Group
Expansions & Relocations (June 29-July 5): A Big Week in Texas for ...
CoStar Group, MD - Jul 3, 2008
A Texas community college has completed a deal to buy RadioShack's plush, 18.7 acre, 900000-square-foot headquarters campus in downtown Fort Worth, TX, ...T - BCSI - KALU
On The Town: Celebrities treat for tips
Toledo Blade, OH - Jun 16, 2008
THE University of Toledo College of Business Alumni Affiliate celebrity wait night was March 24 at Ciao! Restaurant with 138 diners in attendance. ...
Disrespecting the Federalist Papers
History News Network, WA - Jun 22, 2008
By Michael I. Meyerson Mr. Meyerson is the author of Liberty's Blueprint: How Madison and Hamilton Wrote The Federalist, Defined the Constitution, ...

Endocrine Today
Studies, data and dialogue needed to determine TSH range
Endocrine Today, NJ - Jun 10, 2008
Endocrine Today spoke with Hamilton and other thyroid experts to determine what has caused the controversy, where research stands and what it might take to ...
HW's Lanois, Prep's Brakeley named Moynihan Student-Athletes of ...
Gloucester Daily Times,  USA - Jun 10, 2008
PEABODY ? Emily Lanois has been running cross country and track since the day she showed up at Hamilton-Wenham Regional High School three years ago. ...
Source: Google News

A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their … -
MB Keller, JP McCullough, DN Klein, B Arnow, DL … - New England Journal of Medicine, 2000 - content.nejm.org
... of major depression are difficult to treat, and the ... 20 on the 24-item Hamilton Rating
Scale for ... of Psychiatry, Cornell University Medical College, New York (JCM ...

Treatment of Depressive Symptoms in Human Immunodeficiency Virus-Positive Patients -
JC Markowitz, JH Kocsis, B Fishman, LA Spielman, … - Archives of General Psychiatry, 1998 - archpsyc.highwire.org
... and Completer Samples (n=69), Hamilton Depression Rating ... 42% for the intent-to-treat
sample; and ... Research at Cornell University Medical College, New York, NY. ...
-

Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid … -
RA Hamilton - Rheumatology, 1997 - Br Soc Rheumatology
... across the dose range used to treat patients with ... to: JM Kremer, Albany Medical College,
New Scotland Avenue ... HAMILTON AND KREMER: WHY im MTX MAY WORK BETTER 87 ...

Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery … -
… -Waili, GJ Butler, J Beale, RW Hamilton, BY Lee, P … - Med Sci Monit, 2005 - journals.indexcopernicus.com
... J. Butler, Jorge Beale, Roger W. Hamilton, Bok Y ... Westchester Medical Center, New
York Medical College, New York, USA ... the 19 th century to treat caisson workers ...

REACH Clinical Feasibility of a Rural Telestroke Network -
DC Hess, S Wang, W Hamilton, S Lee, C Pardue, JL … - Stroke, 2005 - Am Heart Assoc
... C. Hess, MD ; Samuel Wang, MS ; William Hamilton, MBA, MHA ... Medical College of Georgia
(MCG) evidence-based stroke pathways ... A decision to treat or not to treat ...

Anemia is associated with worse symptoms, greater impairment in functional capacity and a … -
… Horwich, GC Fonarow, MA Hamilton, WR MacLellan, J … - Journal of the American College of Cardiology, 2002 - Am Coll Cardio Found
... 39:1780-1786 ? 2002 by the American College of Cardiology ... C. Fonarow, MD, FACC ,* ,
Michele A. Hamilton, MD, FACC ... it was not routine to treat these patients ...

… -based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat -
A Barratt, PC Wyer, R Hatala, T McGinn, AL Dans, S … - Canadian Medical Association Journal, 2004 - Can Med Assoc
... risk reduction and number needed to treat. ... and Biostatistics, McMaster University,
Hamilton, Ont. ... project director), Columbia University College of Physicians ...

[BOOK] Women's Mental Health: A Comprehensive Textbook -
SG Kornstein - 2005 - books.google.com
... symptoms, course of illness, treat- ment options ... Joseph's Hospital, Hamilton, Ontario,
Canada Marie Stoner, MEd ... of Pediatrics, Albert Einstein College of Medicine ...

[BOOK] German Baroque Poetry, 1618-1723
RM Browning - 1971 - Pennsylvania State University Press
-

Programming for Multicultural Competencies -
M Howard-Hamilton - New Directions for Student Services, 2000 - doi.wiley.com
... This question is handled in more detail in Howard-Hamilton, Phelps, and Torres ... How
will we treat the growing diverse populations on our college campuses ...

Source: Google Scholar
 

Hamilton College Researchers Discover New Molecules with the Potential to Treat Breast Cancer

Article published in Highly Cited Journal of the American Chemical Society

Contact: Holly Foster
Phone: (315) 859-4068
May 4, 2007

Hamilton College researchers have identified molecules that have been shown to be effective in the fight against breast cancer.

The Hamilton researchers used state-of-the-art computational techniques in a novel way to design molecules that they predicted would be effective lead compounds for breast cancer research. Scientists from the Albany Medical College subsequently synthesized the predicted molecules and showed that they were indeed potential anti-breast cancer compounds in animal systems.

A paper detailing the research, “Computational Design and Experimental Discovery of an Anti-estrogenic Peptide Derived from Alpha-Fetoprotein,” will be published in the May 16 issue of the Journal of American Chemical Society.

Article continues below and (thank you)
 

Figure of the an active 8 amino acid peptide. Solvent accessible surface is shown.

Figure of the an active 8 amino acid peptide. Solvent accessible surface is shown.
 
Winslow Professor of Chemistry George Shields and co-director of the Center for Molecular Design Karl Kirschner led the Hamilton research team with undergraduate students Katrina Lexa ‘05, Amanda Salisburg ‘08, Katherine Alser ‘09. The Albany team consisted of Leroy Joseph, Thomas Andersen, James Bennett, and Herbert Jacobsen of Albany Medical College.

Breast cancer is the most common cancer among women and tamoxifen is the preferred drug for estrogen receptor-positive breast cancer treatment. Many of these cancers are intrinsically resistant to tamoxifen or acquire resistance during treatment. Consequently, there is an ongoing need for breast cancer drugs that have different molecular targets.

Previous work by the Albany Medical College researchers had shown that 8-mer and cyclic 9-mer peptides inhibit breast cancer in mouse and rat models, interacting with an unsolved receptor, while peptides smaller than eight amino acids did not.

The Hamilton researchers used advanced computational methods to predict the structure and dynamics of active peptides, leading to discovery of smaller peptides with full biological activity. The results were used to identify smaller peptides with the three dimensional structure of the larger peptides. These peptides were synthesized and shown to inhibit estrogen-dependent cell growth in a mouse uterine growth assay, a test showing reliable correlation with human breast cancer inhibition.

This work was funded by the National Institutes of Health, the New York State Breast Cancer Research and Education fund, the Department of Defense's Breast Cancer program, and the National Science Foundation.

Founded in 1879, the Journal of the American Chemical Society is the flagship journal of the American Chemical Society and the premier medium for the worldwide publication of fundamental research in all areas of the chemical sciences. It is the most highly cited chemistry journal.

The results reported in the published article were first presented by Professor Shields at the 2006 International Symposium on Theory and Computations in Molecular and Materials Sciences, Biology and Pharmacology, on February 26, 2006, St. Simon’s Island, Ga.


The project was sponsored in part by the Department of the Army under contract # W81XWH-05-1-0441. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014 is the awarding and administering acquisition office. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.

It was supported by the New York State Breast Cancer Research and Education Fund through Department of Health Contract # C017922. Opinions expressed are solely those of the author and do not necessarily reflect those of the Health Research Science Board, the New York Department of Health, of the State of New York.

This material is based upon work supported by the National Science Foundation under Grant No. (CHE-0457275). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

Part of the Federal support came from the National Institutes of Health/National Cancer Institute. Federal money represents $475,870 or 82% of total project costs; non-federal funds equal $100,000 or 18% of total project costs.
 
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