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Recent News and Articles on the Keywords: fracture risk + osteoporosis risk + risk  Related to the article below (Last Update: 8/5/2008)

Evaluation of Patients with a recent Clinical Fracture and ...
7thSpace Interactive (press release), NY -
44%, p<0.05) and a higher calculated absolute 10-year risk for major (16.5 vs. 9.9%, p<0.01) and for hip fracture (6.9 vs. 2.4%, p<0.01) than patients ...
?Asians at high risk of deadly bone disease?
Daily Times, Pakistan - Aug 2, 2008
They said Asians were at high risk of osteoporosis, as by 2050 more than half of hip fracture cases due to decreased bone mass worldwide would be in Asia, ...
Osteoporosis rising in Asia: experts Pakistan Dawn
Asians at high risk of osteoporosis The News - International
all 4 news articles »
Osteoporosis affects 600000 Aussies
The Age, Australia -
Once a spinal fracture happened the risk of further spinal fractures dramatically increased and when vertebrae were weakened by osteoporosis, normal spinal ...
Drug Companies Exaggerate Benefits of Osteoporosis Drugs to Women
Natural News.com, AZ - Aug 3, 2008
"But in women with pre-osteoporosis, the risk of fracture is very low, say 1 percent a year, so if you lower that by half, you go down to an 0.5 percent ...
Over half million suffer osteoporosis
ScienceAlert, Australia -
At least 600000 Australians are affected by osteoporosis, a disease that causes bones to become fragile and weak and increasing the risk of fracture, ...
Osteoporosis?Not Just a Women?s Concern
Medfinds, WA - Aug 1, 2008
Androgen deprivation therapy, a prostate cancer therapy that reduces testosterone levels, was also found to significantly increase fracture risk. ...
Genetics, lifestyle affect bone density
Daytona Beach News-Journal, FL - Aug 3, 2008
Still, men have a 17 percent chance of experiencing an osteoporotic hip fracture in their lifetime. Some people are at greater risk of osteoporosis than ...
Amgen Gets Much Needed Denosumab Boost
Seeking Alpha, NY - Jul 29, 2008
Positive phase III data from Amgen (AMGN) on Denosumab, which significantly reduced the risk of bone fracture in post-menopausal women, has reinforced many ...AMGN

Los Angeles Business Journal (subscription)
Amgen Shares Jump on Osteoporosis Drug
Los Angeles Business Journal (subscription), CA - Jul 28, 2008
... late Friday that a late-stage study showed the osteoporosis drug denosumab significantly reduced the risk of bone fracture in post-menopausal women. ...AMGN
Amgen shares, propped by bone drug, may move higher
guardian.co.uk, UK - Aug 1, 2008
But he noted that the drug needs to clear a fairly high bar -- commonly used osteoporosis drugs cut fracture risk by about 50 percent -- and past trial ...AMGN
Source: Google News

Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With … -
B Ettinger, DM Black, BH Mitlak, RK Knickerbocker, … - JAMA, 1999 - Am Med Assoc
... Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated
With Raloxifene Results From a 3-Year Randomized Clinical Trial. ...

… Low Bone Mineral Density in Postmenopausal Women Results From the National Osteoporosis Risk … -
ES Siris, PD Miller, E Barrett-Connor, KG Faulkner … - JAMA, 2001 - Am Med Assoc
... Context Large segments of the population at risk for osteoporosis and fracture have
not been evaluated, and the usefulness of peripheral measurements for short ...

… ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis
CH CHESNUT, A SKAG, C CHRISTIANSEN, R RECKER, JA … - Journal of bone and mineral research(Print), 2004 - cat.inist.fr
Effects of Oral ibandronate administered daily or intermittently on fracture
risk in postmenopausal osteoporosis. Charles H CHESNUT ...

Diagnosis of osteoporosis and assessment of fracture risk -
JA Kanis - The Lancet, 2002 - Elsevier
... LM Salamone et al., The epidemiology of quantitative ultrasound: a review of the
relationship with bone mass, osteoporosis and fracture risk, Osteoporos Int 7 ...

Fracture Risk Reduction with Alendronate in Women with Osteoporosis: The Fracture Intervention Trial -
DM Black, DE Thompson, DC Bauer, K Ensrud, T … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc
... In addition, we examine the time course of the effect of alendronate on
clinical fracture risk in these women with osteoporosis. ...

Effect of Risedronate on the Risk of Hip Fracture in Elderly Women. -
MR McClung, P Geusens, PD Miller, H Zippel, WG … - Obstetrical & Gynecological Survey, 2001 - obgynsurvey.com
... Analysis of 1-year Vertebral Fracture Risk Reduction Data in Treatments for
Osteoporosis. Southern Medical Journal. 96(5):478-485, May 2003. ...

… of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a … -
JA Kanis, JA Kanis - Osteoporosis International, 1994 - Springer
... and evidence that such measurements improve the prediction of fracture risk. ... should
be determined in vivo in healthy individuals or patients with osteoporosis. ...

… of Fracture in Women With Low Bone Density but Without Vertebral Fractures Results From the Fracture … -
SR Cummings, DM Black, DE Thompson, WB Applegate, … - JAMA, 1998 - Am Med Assoc
... One needs to treat relatively few patients with osteoporosis, who have a high risk
of fractures, to prevent a radiographic vertebral fracture, clinical fracture ...

Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. -
O Johnell, B Gullberg, JA Kanis, E Allander, L … - J Bone Miner Res, 1995 - ncbi.nlm.nih.gov
J Bone Miner Res. 1995 Nov;10(11):1802-15. Risk factors for hip fracture in European
women: the MEDOS Study. Mediterranean Osteoporosis Study. ...

… White Women With Peripheral Bone Densitometry: Evidence From the National Osteoporosis Risk … -
PD MILLER, ES SIRIS, E BARRETT-CONNOR, KG FAULKNER … - Journal of Bone and Mineral Research, 2002 - Am Soc Bone Min Res
... Santora and Louis M Sherwood. (2005) Osteoporosis and Fracture Risk in Women
of Different Ethnic Groups. Journal of Bone and Mineral ...

Source: Google Scholar
 

Annual injection lowers osteoporosis fracture risk

Last Updated: 2007-05-02 17:00:26 -0400 (Reuters Health)

NEW YORK (Reuters Health) - A once-a-year infusion of zoledronate, which goes by the brand names Zometa and Reclast, can significantly reduce the risk of fractures of the spine and hip in postmenopausal women with brittle bones due to osteoporosis, according to a report in this week's New England Journal of Medicine.

In earlier studies, yearly treatment with zoledronate was shown to improve bone density, but it was unclear if this translated into a significant reduction in fracture risk.

In the current study, Dr. Dennis M. Black, from the University of California, San Francisco, and colleagues assessed the occurrence of fractures in 3889 women, average age 73 years, with postmenopausal osteoporosis who were randomly assigned to receive annual treatment with zoledronate or an inactive placebo.

Article continues below and (thank you)
 

Compared with placebo, zoledronate reduced the risks of vertebral, hip, and other fractures by 70 percent, 41 percent, and 25 percent, respectively.

In general, zoledronate therapy was not associated with any more adverse effects than the placebo. However, while uncommon, serious atrial fibrillation -- in which the upper chambers of the heart beat rapidly but weakly -- affected significantly more patients in the zoledronate group (50) compared with the placebo group (20).

In a related editorial, Dr. Juliet Compston, from the University of Cambridge School of Clinical Medicine in the UK, comments that while the findings are encouraging, "the practicality and acceptability of annual intravenous therapy in large numbers of women remain to be tested."

Nevertheless, she writes, "Increased treatment choices for patients are to be welcomed and may provide one means of improving adherence and treatment outcomes in osteoporosis."

SOURCE: New England Journal of Medicine, May 3, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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