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Recent News and Articles on the Keywords: heart + infection + increased  Related to the article below (Last Update: 8/5/2008)


Washington Post
Hand Washing: Time Well Spent
Washington Post, United States -
Reston Hospital Center has boosted its hand-hygiene compliance, which has led to a drop in the infection rate. (By Rui Vieira -- Press Association Via ...
The Germs Are Potent. But So Is a Kiss. New York Times
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Illicit-firework victim will undergo surgery today
Salt Lake Tribune, United States -
An 11-year-old is fighting a serious infection in a wound caused by a homemade firework, his family said. Bridger Hunt was to undergo surgery today tuesday ...

eFluxMedia
Growth Hormone Reduces Abdominal Fat, Cardiovascular Risk In HIV ...
Science Daily (press release) -
However, growth hormone treatment appeared to increase blood glucose levels, particularly in those already exhibiting glucose intolerance. ...
Daily Doses of Growth Hormone May Aid HIV Patients eFluxMedia
Mixed results for growth hormone in HIV patients The Associated Press
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Pupils save heart attack teacher
This is Wiltshire.co.uk, UK - 21 minutes ago
He has had a further two heart attacks and suffered from pneumonia and a kidney infection. When he regained consciousness Mr Wilson thought he was at his ...
North Iowan awaits heart transplant
Mason City Globe Gazette, IA -
Physicians discovered he had contracted a bacterial infection related to the LVAD device. Toomsen underwent daily infusions of a drug to kill the bacteria ...
On heart transplant anniversary, Hazlet survivor runs 20 miles
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Trained as a nurse, Harmer could not return to that field after his transplant because his immune suppressant medication made him susceptible to infection. ...
Entries in Weight Gain (7)
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Aptly named, these adhesions develop in response to a wide range of tissue injuries including infection, surgery, blunt trauma, and radiation treatment. ...
Lyme disease cases grow
Acton-The Beacon, MA - Aug 3, 2008
Children between the ages of 5 and 14 and adults between 45 and 54 are the most susceptible to infection and men are more likely to be infected than women, ...
Justice: a cry from the heart
Manly Daily, Australia -
The knife wound pierced his heart and lung and the St Luke's Grammar student was rushed to the Royal North Shore Hospital where he was fighting for his life ...
Foot Care for Diabetics
Diabetes Health (press release), CA -
If this increase in flow is unavailable, the injury will probably deteriorate, becoming gangrenous, and facilitate an infection that spreads up the leg. ...
Source: Google News

Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum … -
S Niemela, T Karttunen, T Korhonen, E Laara, R … - British Medical Journal, 1996 - heart.bmj.com
... YA concentrations? coronary heart disease by modifying serum lipid Could
Helicobacter pylori infection increase the risk of http ...

Do Protease Inhibitors Increase the Risk for Coronary Heart Disease in Patients With HIV-1 Infection … -
D Klein, LB Hurley, CP Quesenberry Jr, S Sidney - JAIDS Journal of Acquired Immune Deficiency Syndromes, 2002 - jaids.org
... NHIS) of the CDC/NCHS.CHD, coronary heart disease (ICD-9 410 ... that HIV-positive men
are at increased risk of ... higher rate among persons living with HIV infection. ...

Relation of Helicobacter pylori infection and coronary heart disease -
MA Mendall, PM Goggin, N Molineaux, J Levy, T … - British Medical Journal, 1994 - heart.bmj.com
... DB Howard, and BE Sobel Increased reactivity of ... Relation of Helicobacter pylori
Infection to 13-Year ... pylori Seropositivity and Coronary Heart Disease Incidence ...

Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 … -
J Danesh, R Peto - BMJ: British Medical Journal, 1998 - pubmedcentral.nih.gov
... PubMed]. 2. Karttunen T, Niemela S. Increased blood leukocytes ... Prospective relations
between Helicobacter pylori infection, coronary heart disease, and ...

Association of Virulent Helicobacter pylori Strains With Ischemic Heart Disease -
V Pasceri, G Cammarota, G Patti, L Cuoco, A … - Circulation, 1998 - Am Heart Assoc
... infection and mortality from ischemic heart disease: negative ... PH, Stemmermann GN,
Nomura A. Infection with Helicobacter ... is associated with an increased risk of ...

… of Helicobacter pylori Infection to 13-Year Mortality and Incident Ischemic Heart Disease in the … -
DP Strachan, MA Mendall, D Carrington, BK Butland, … - Circulation, 1998 - Am Heart Assoc
... they raise the possibility of an increased risk of ... However, because H pylori infection
is potentially treatable ... was supported by the British Heart Foundation (PG ...

Prospective relations between Helicobacter pylori infection, coronary heart disease, and stroke in … -
PH Whincup, MA Mendall, IJ Perry, DP Strachan, M … - British Medical Journal, 1996 - heart.bmj.com
... whether Helicobacter pylori, a chronic bacterial infection often acquired in childhood,
is associated with increased risk of coronary heart disease and stroke ...

… mortality and incidence of ischaemic heart disease over 13 years in the Caerphilly prospective heart … -
DP Strachan, D Carrington, MA Mendall, L Ballam, J … - BMJ: British Medical Journal, 1999 - pubmedcentral.nih.gov
... Saikku et al reported increased concentrations of IgG ... between markers of chronic
infection with C ... and various manifestations of ischaemic heart disease (angina ...

Chronic Chlamydia pneumoniae Infection Is Associated With a Serum Lipid Profile Known to Be a Risk … -
A Laurila, A Bloigu, S Nayha, J Hassi, M Leinonen, … - Arteriosclerosis, Thrombosis, and Vascular Biology, 1997 - Am Heart Assoc
... HDL cholesterol, and especially a decreased HDL cholesterol ... Helicobacter pylori
infections, with coronary heart disease in ... from the effect of infection on lipid ...

… pylori infection: relation with cardiovascular risk factors, ischaemic heart disease, and social … -
LJ Murray, KB Bamford, DP O'Reilly, EE McCrum, AE … - British Medical Journal, 1995 - heart.bmj.com
... is not through increased concen- tration of plasma fibrinogen. H pyloni infection
does not explain the social class inequality in ischaemic heart disease which ...

Source: Google Scholar
 

Heart at Increased Risk from HIV Infection

A new study has found that people who are HIV positive can face nearly double the risk of a heart attack than those who are not. The risk remains high across all ages, blood pressure conditions as well as high cholesterol and other cardiovascular risk factors.

The findings are shocking as they suggest that the virus itself or therapies used for treating HIV infection might be harming the heart in some manner. The findings of the study have been reported in the online edition of the Journal of Clinical Endocrinology and Metabolism.

Article continues below and (thank you)
 
The research team from Harvard Medical School, led by Associate Professor of Medicine Dr. Steven Grinspoon used demographic and diagnostic data for more than 1.7 million patients for their study. All the patients had been treated at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital, both in Boston, between 1993 and 2001.

The researchers analysed the data and compared outcomes for the nearly 4,000 HIV-infected patients with information on the remaining more than 1 million patients. The HIV-infected patients were aged between 18 and 84 years.

They found that the HIV-patients had overall risk of suffering a heart attack that was twice that of the age-matched control patients. Women were found to be especially at higher risk with heart attack odds nearly tripling after they became infected. Against that, infected men faced a 40% increase in their heart attack risk upon infection.

The research team took into account and adjusted for age and other heart disease risk factors such as high blood pressure, high blood cholesterol and diabetes.

“We don’t know why that is – whether women have more serious metabolic changes or not,” said Dr. Grinspoon, who also directs Massachusetts General Hospital’s Program in Nutritional Metabolism. “Traditional risk factors may be accounting for more of the (heart attack) rates in women than in men, and there may be other things related to body composition that we couldn’t factor in.”

“The link between HIV, the virus that causes AIDS, and heart disease isn’t new,” noted Rowena Johnston, Vice President of Research at the Foundation for AIDS Research (amfAR), based in New York City. “We have certainly suspected that for a long time,” she said.

In 2005, a major European Study, the Data Collection on Adverse Events of Anti-HIV Drugs (DAD) had reported that HIV-positive patients are at nearly twice the heart attack risk in comparison to uninfected individuals of the same age. However statistics from the new study are much more powerful.

The researchers also found a difference in the heart attack risk between black and white patients with black people being at comparatively higher risk. This led researchers and experts to the question of whether HIV is capable of increasing heart risk on its own. However the researchers haven’t been able to find an answer to the question yet.

“HIV is a virus, so (infection) is an inflammatory state,” Dr. Grinspoon said. Chronic inflammation has recently been linked to cardiovascular disease, so “one hypothesis would be that these patients have a pro-inflammatory condition,” he said.

The researchers noted that most of the HIV-infected patients in the study were also taking the powerful cocktail of HIV-suppressing drugs collectively known as “highly active antiretroviral therapy” (HAART).

On the one hand, “HAART suppresses inflammation, which can improve cardiovascular parameters,” Dr. Grinspoon noted. “But, on the other hand, treatment with HAART also leads to worsening changes in body composition and has even more adverse effects on (blood) glucose, lipids, etcetera. So, it’s a mixed bag.”

“We don’t mean to scare people off their meds – they need to take the meds to survive. But doctors should also be aware of this increased risk,” said Dr. Grinspoon. “Other factors may also boost heart risk for people with HIV,” Johnston added.

Commenting on the study population, she noted that the HIV-infected participants were more likely to smoke heavily. In her opinion this was not surprising considering the fact that they were living under the stress caused by the virus. And smoking in itself is a major risk factor for heart disease, she added.

Johnston emphasized that the findings should not make patients wary of taking their medications. “There’s no doubt that antiretroviral therapy is saving lives, regardless of whether there’s an increase in (heart attack),” she said. “The benefits of antiretroviral therapy certainly outweigh those risks.”

At the same time Johnston advised doctors caring for people living with HIV to be vigilant in tracking the cardiovascular health of their patients. Agreeing with Johnston’s advice, Dr. Grinspoon added, “Doctors need to be aware of this increased risk, and that it occurs even among young HIV patients.”

“Sometimes with (young) patients who might have chest pain, you might not ordinarily be concerned, but we are suggesting that doctors pay serious attention to that, because there is this increased risk of cardiovascular disease.”
 
 
 
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