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Recent News and Articles on the Keywords: sleeping + research + sickness  Related to the article below (Last Update: 8/5/2008)

Behavioral Comorbidities in Rheumatoid Arthritis
Psychiatric Times, NY -
Alternately, both sleep disturbance and depression may be manifestations of an underlying biological disturbance. To date, research on RA ?sickness ...
Neighbor in need
Russellville Courier, AR -
Even in her sickness, she is looking forward to the future, including her 30-year high school reunion (Richardson is a member of the Russellville High ...
Fruita Relay participants, supporters up all night for good cause
Grand Junction Free Press, Colorado - Aug 4, 2008
Martell doesn?t understand his sickness. Martell has spent much of the last year being treated at Phoenix Children?s Hospital. His dad is in the military, ...
Climber raises money for breast cancer research
Sammamish Review, wa - Jul 30, 2008
?As you descend, it starts getting better and better,? Gage said about her altitude sickness. ?Usually people are very excited, but that?s only half the ...

UK Trade & Investment
New Scottish medical lab opens
UK Trade & Investment, UK - Jul 29, 2008
The ?1-million facility will research a range of viral and parasitic diseases such as influenza and sleeping sickness, by providing a secure space for the ...
Column: Dental care part of healthy pregnancy
Wausau Daily Herald, WI -
If brushing aggravates your morning sickness, try a bland toothpaste or rinse your mouth out with water or a rinse you can tolerate. ...
Upstream Begins Animal Efficacy Testing for Leishmaniasis Treatment
MarketWatch - Jul 28, 2008
Leishmaniasis, Trypanaosomiasis (African sleeping sickness), and Malaria are caused by related parasites that have developed resistance to available ...
? Social Lives of Bacteria May Yield Benefits for Humans Social ...
Washington Post, United States - Jul 27, 2008
Malaria, Chagas' disease and sleeping sickness are just a few of the many human diseases caused by protozoa. There is also reason to think that some ...
Climate change, lack of research to exacerbate sickle cell disease ...
Africa Science News Service, Kenya - Jul 29, 2008
?Now we (Sanofi-Aventis) are now working on a new research on sleeping sickness, commissioned by WHO. Sebbag said the only hope for sickle cell disease is ...
Investment in research good for development ? Expert
The Tide, Nigeria - Jul 28, 2008
Nwaka explained that such diseases like malaria, African sleeping sickness and parasitic worms diseases were claiming the lives of many Africans. ...
Source: Google News

Waking up to sleeping sickness -
A Stich, MP Barrett, S Krishna - Trends in Parasitology, 2003 - Elsevier
... Fig. 1. Research articles for malaria and sleeping sickness. The research
outputs for Plasmodium falciparum (red) and Trypanosome ...

Comparison of three measures of quality of life outcome in the evaluation of continuous positive … -
C JENKINSON, J STRADLING, S PETERSEN - Journal of Sleep Research - Blackwell Synergy
... The FLP was developed from an American instrument, the Sickness Impact Profile
(SIP) (Bergner et al. 1976; Bergner et ... 1997 European Sleep Research Society, J ...

[PDF] Treatment of human African trypanosomiasis-present situation and needs for research and development. -
D Legros, G Ollivier, M Gastellu-Etchegorry, C … - Lancet Infectious Diseases, 2002 - dndi.org
... Trypanosoma brucei Personal view Sleeping sickness research agenda DL is ... pancytopenia,
diarrhoea, Personal view Sleeping sickness research agenda Table 1 ...

Is there a link between subjective daytime somnolence and sickness absenteeism? A study in a working … -
P Philip, J Taillard, I Niedhammer, C … - Journal of Sleep Research, 2001 - Blackwell Synergy
... B. (2001) Is there a link between subjective daytime somnolence and sickness
absenteeism? A study in a working population. Journal of Sleep Research 10 (2), ...

… studies on the animal reservoir of Gambiense sleeping sickness. Part III. Characterization of … -
D Mehlitz, U Zillmann, CM Scott, DG Godfrey - Tropenmed Parasitol, 1982 - ncbi.nlm.nih.gov
... resistant to normal human serum and had been previously associated with chronic
gambiense sleeping sickness. Publication Types: Research Support, Non-US Gov't. ...

Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by … -
SC Welburn, K Picozzi, EM F?vre, PG Coleman, M … - The Lancet, 2001 - Elsevier
... EMF is also supported by the UK Medical Research Council ... 1 T K?erner, P de Raadt
and I Maudlin, The 1901 Uganda sleeping sickness epidemic revisited: a case of ...

… prostaglandin D2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness … -
VW Pentreath, K Rees, OA Owolabi, KA Philip, F … - Trans R Soc Trop Med Hyg, 1990 - ncbi.nlm.nih.gov
... brucei gambiense in the central nervous system (CNS) in advanced sleeping sickness
patients, levels ... Publication Types: Research Support, Non-US Gov't. MeSH Terms ...

Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness -
A Hofer, D Steverding, A Chabes, R Brun, L … - Proceedings of the National Academy of Sciences of the …, 2001 - pubmedcentral.nih.gov
... or cytidine, might prove useful against both sleeping sickness and malaria.
Acknowledgments. We thank Anne Simmonds (Purine Research Laboratory, United Medical ...

The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda -
EM F?vre, PG Coleman, M Odiit, JW Magona, SC … - The Lancet, 2001 - Elsevier
... Acknowledgments. EMF is supported by the UK Medical Research Council. ... References.
1 MP Barrett, The fall and rise of sleeping sickness, Lancet 353 (1999), pp. ...

… of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma … -
C Burri, S Nkunku, A Merolle, T Smith, J Blum, R … - The Lancet, 2000 - Elsevier
... Articles. Efficacy of new, concise schedule for melarsoprol in treatment of sleeping
sickness caused by Trypanosoma brucei gambiense: a randomised trial. ...

Source: Google Scholar
 

Pioneering research on sleeping sickness wins MERIAL Award for Parasitology

Brussels, Belgium - Stefan Magez, a VIB researcher connected to the Vrije Universiteit Brussel,
has won this year’s MERIAL Award for Parasitology. For a number of years now, he has been
studying the parasite that causes sleeping sickness (African trypanosomiasis). This deadly
disease strikes about 300,000 new patients each year, thousands of whom die. Not only is
Stefan Magez trying to discover how the parasite makes us sick, he’s also searching for
methods to detect the disease more quickly, to treat it more effectively and, ultimately, to
prevent it. He has now laid the foundation for a possible therapy, and the initial results in mice
are very promising. MERIAL is rewarding Stefan Magez for his research to date with the
prestigious MERIAL Award for Parasitology, which includes a monetary award of €2500.
Sleeping sickness

Article continues below and (thank you)
 
Press Release - Science
Brussels, Belgium – 26 April 2007


Sleeping sickness afflicts both humans and livestock and occurs primarily in Sub-Sahara Africa. Every year,
thousands of people die of this disease. The death of livestock in the countries afflicted leads to an economic
loss of more than one billion euro. Today, vaccination against trypanosoma, the parasite that causes
sleeping sickness, is not at all effective, and the only remedy that works in all stages of infection is based on
arsenic, which has severe side effects and can be deadly itself. So, Stefan Magez and his colleagues are
seeking a possible alternative medicine.
An important role for TNF
Since 1992, this Flemish researcher has been focusing his attention on the role that TNF (Tumor Necrosis
Factor) plays in sleeping sickness. Our body produces TNF as a protection against a number of microorganisms.
About 20 years ago, scientists discovered that animals that have been infected with African
trypanosoma produce far too much TNF. Through his research, Stefan Magez has shown that a trypanosoma
infection prompts the immune system to produce TNF to eliminate the parasite from the body - but for
some reason the amount of TNF produced is excessive. This over-production of TNF leads to symptoms such
as anemia and extreme weight loss, which can result in death.
The search for a vaccine
These findings have led Magez and his colleagues to try to prevent the over-production of TNF. To do this,
they have formulated vaccines that target the components of trypanosoma that induce TNF production.
Initial results in mice are very encouraging, and the researchers will test the medicine this year in Kenya,
where the disease occurs primarily in cattle.
Rewarding innovative research in the Benelux
The MERIAL Award, which honors a medical or veterinary parasitologist, is awarded annually to a postdoctoral
researcher from the Benelux who has conducted outstanding innovative work. The prize is being
awarded for the tenth time this year. MERIAL, the Dutch Parasitology Association, and the Belgian
Parasitology Association distribute the prize.
Given that this research can raise a lot of questions for patients, we ask you to please refer questions in
your report or article to the email address that VIB makes available for this purpose: patienteninfo@vib.be.
Everyone can submit questions concerning this and other medically-oriented research directly to VIB via this
address.
 
Note to the Editor
VIB, the Flanders Institute for Biotechnology, is a non-profit research institute in the life sciences. Some
1000 scientists and technicians conduct strategic basic research on the molecular mechanisms that control
the functioning of the human body, plants, and micro-organisms. Through a close partnership with four
Flemish universities - Ghent University, the Katholieke Universiteit Leuven, the University of Antwerp, and
the Vrije Universiteit Brussel - and a solid investment program, VIB unites the forces of 65 research groups
in a single institute. Their research aims at fundamentally extending the frontiers of our knowledge. Through
its technology transfer activities, VIB strives to convert the research results into products for the benefit of
consumers and patients. VIB also develops and distributes a broad range of scientifically substantiated
information about all aspects of biotechnology. More info at: www.vib.be
Funding
A great deal of international collaboration has been necessary to achieve the present results, and a number
of entities and organizations have provided financial support. For the past 9 years, Stefan Magez has been a
post-doctoral researcher of the Fonds voor Wetenschappelijk Onderzoek – Vlaanderen (FWO). The
laboratory for Cellular and Molecular Immunology of the Vrije Universiteit Brussel, where most of the
awarded research was conducted, is a part of VIB. A portion of the work was carried out at the University of
Cape Town, under the form of a bilateral collaborative agreement between Flanders and South Africa. The
vaccination program is currently being funded by the European Union (FP6).
For more information
For more information, please contact VIB’s Communication service:
VIB Communication: +32 9 244 66 11
Stefan Magez leads the Immunoparasitology group in the VIB Department of Molecular and Cellular
Interactions, at the Vrije Universiteit Brussel, under the direction of Lode Wyns (for more inf
 
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