Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

Recent News and Articles on the Keywords: 10,900 + web + 0.30  Related to the article below (Last Update: 8/5/2008)

Post-Anthrax, Mail Sent Around Inconvenience Washington Post, United States - Aug 2, 2008 The average amount of mail irradiated each month has fallen from 23700 containers per month in 2002 to 10900 containers as of April, according to the ... Man fatally shot after dispute; 1 arrested Tulsa World, OK - Aug 3, 2008 Detectives arrested Lara at his home in the 10900 block of East 36th Street at 3 pm Saturday. He was booked into the Tulsa Jail on a first-degree murder ... CB Richard Ellis Group, Inc. Reports Second Quarter 2008 Revenue ... WELT ONLINE, Germany - Jul 29, 2008 A live webcast will be accessible through the Investor Relations section of the Company?s Web site at www.cbre.com. The direct dial-in number for the ...CBG Four local colleges offer higher education Inside NoVA, VA - Jul 31, 2008 The Prince William campus, at 10900 University Blvd. near the city of Manassas, houses programs in the life sciences, including bioscience, biotechnology, ... LB Foster Reports Record Second Quarter Operating Results MarketWatch - Jul 24, 2008 Listen via audio on the LB Foster web site: http://www.lbfoster.com, by accessing the Investor Relations page. The Company wishes to caution readers that ...FSTR Bellevue Reporter Community Calendar | July 26 Bellevue Reporter, WA - Jul 26, 2008 Skyline Tower, 10900 NE Fourth St., ninth floor conference room, Bellevue. www.wrytoastmasters.org. YMCA Seniors? Group: 10 am-2 pm Tuesdays and Thursdays. ... Colonial Heights Progress Index, VA - Jul 17, 2008 Quantisha M. Staton, 19, of the 10900 block of Timonium Drive, Chester, was charged with larceny: petit in the 600 block of Southpark Boulevard on June 30. ... North Palm Beach County events calendar: July 30 TCPalm, FL - Jul 30, 2008 John D. MacArthur Beach State Park: 10900 State Road 703, east of PGA Blvd., North Palm Beach. Admission is $4 per car load. Call (561) 624-6952 or visit ... Market Mayhem ADOTAS, NY - Jul 17, 2008 The most recent being June 14, 2008 to July 15, 2008 - 12300 to 10900. With the Dow down more than 2000 points this year and 4000 from the highs seen ... Engineers Practice Environmental Sustainability RedOrbit, TX - Jul 7, 2008 The institute has 10900 members including scientists, engineers, technologists, and organizations. The US Green Building Council in Washington, DC, ...

Post-Menopausal Females, The Elderly And Males Most Heavily Impacted
By A Chemical Component Of Diesel Exhaust Particles

Estrogen appears to provide protective effects in animal model

WASHINGTON – A new study finds that exposure to a chemical component of diesel exhaust particles can compromise the ability of resistance arteries to regulate blood flow to bone marrow. Post-menopausal females, the elderly and males are most likely to be impacted, according to a new vascular biology study– using an animal model – being presented at the 120^th Annual Meeting of The American Physiological Society (APS; www.The-APS.org) from April 28-May 2, 2007 in Washington, DC.

The study, Effects of Age, Gender, and Estrogen on Endothelium-Dependent Vasodilation Subsequent to Phenanthraquinone Exposure, was conducted by Rhonda D. Prisby, Judy Muller-Delp and Timothy R. Nurkiewicz, all of the Center for Interdisciplinary Research in Cardiovascular Sciences at the West Virginia University School of Medicine in Morgantown, WV, USA.  Dr. Nurkiewicz is presenting the findings on behalf of the University’s interdisciplinary cardiovascular research team. The research was funded by the Health Effects Institute and the National Institutes of Health.

Article continues below and (thank you)

Background

Diesel exhaust contributes significantly to the U.S. ambient air pollution burden. This form of air pollution is the product of diesel fuel combustion, commonly generated by buses, trucks, trains and ferries. The particles can remain airborne for extended time periods, and travel long distances prior to being inhaled.  When inhaled, chemical components such as polyaromatic hydrocarbons (PAH) attached to the particles can interact with the body. Quinones are PAHs and are among the more toxic components of diesel exhaust. In the current study, the investigators used phenanthraquinone (PQ) because previous research found PQ to compromise the ability of larger blood vessels to relax.  They have also noted that in certain populations, exposure to particle pollution may exacerbate various cardiovascular diseases.

The principal nutrient artery (PNA) is the major resistance vessel that regulates blood blow to the femoral bone marrow. The ability of arteries to dilate (widen) declines with age and this corresponds with reduced blood flow in an artery’s target organ. Impaired blood flow regulation in the bone marrow can have wide- and long-reaching health consequences. It is unclear what PQ does to the ability of this artery to dilate, and how age or gender alters any such effect.

Summary of Methodology

Against this backdrop the research team sought to determine whether PQ impairs vasodilation in the PNA and identify whether age, gender or estrogen alters the presumed effects of PQ.  The researchers isolated and cannulated femoral PNAs from intact and ovariectomized (OVX) female rats (6, 14 and 24 months) and male rats (6 and 24 months). To evaluate the ability of the PNA to dilate when it was incubated with PQ, researchers used the chemical acetylcholine (ACh). A series of ACh doses were administered over time, starting with low doses and graduating to higher doses to produce maximum dilation of the artery

Results

The researchers found that:

• exposure to PQ had greatly compromised – by approximately 65 percent – the ability of the blood vessels to effectively dilate in six month old male rats, but had no effect in female rats;

• at 14 months (female rats) and 24 months (female and male rats), PQ had impaired and abolished vasodilatation, respectively;

• in all OVX rats (i.e., the young females who had lost estrogen due to menopausal status), PQ abolished vasodilatation;

• following the loss of estrogen, particularly at six months where a cardioprotective effect was previously observed, PQ exposure had obliterated vasodilation.

Conclusion

This study demonstrates that exposure to the diesel particle component PQ, can compromise the ability of the PNA to regulate bone marrow blood flow in males, the elderly and post-menopausal females in an animal model. These findings may provide an important link to other discoveries involving the protective effects of estrogen to environmental pollutants.

***

The American Physiological Society (APS) has been an integral part of the scientific discovery process since it was established in 1887.  Physiology is the study of how molecules, cells, tissues and organs function to create health or disease.

# # #

NOTE TO EDITORS: The APS annual meeting is part of the Experimental Biology 2007 (EB ’07) gathering and will be held April 28-May 2, 2007 at the Washington, DC Convention Center. To schedule an interview with a member of the research team, please contact Donna Krupa at 301.634.7209 (direct dial), 703.967.2751 (cell) or DKrupa@the-APS.org.