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Recent News and Articles on the Keywords: genome + new + 855  Related to the article below (Last Update: 8/4/2008)

New genome sequencing projects announced
United Press International -
4 (UPI) -- The US Department of Energy's Joint Genome Institute has announced its 2009 sequencing projects, including pine trees and duck weed. ...
Next Generation Tool For Visualizing Genomic Data Introduced
Science Daily (press release) -
... and gives them the flexibility to zoom in on a specific genomic region of interest or to pan out for a broad, whole genome view. "This new tool offers a ...
Human Brains Pay A Price For Being Big
Science Daily (press release) -
Research published today in BioMed Central's open access journal Genome Biology adds weight to the theory that schizophrenia is a costly by-product of human ...
Schizophrenia costly byproduct of brain evolution IndiaEduNews.net
all 13 news articles »
NEW $8.9 MILLION PROJECT AIMS TO UNLOCK STEM CELL SECRETS
Wisbusiness.com, WI -
Using proteins found in embryonic stem cells, a group led by blood expert Igor Slukvin and Genome Center scientist Junying Yu will explore how the proteins, ...
Genetic Evidence Used To Trace Ancient African Migration
Science Daily (press release) -
Henn, Mountain and Underhill collaborated with scientists at the Stanford Genome Technology Center; the University of Regensburg, in Germany; ...
Typhoid genome cracked
Healthcare Today, UK -
... has finished sequencing the genome of Salmonelli typhi, the bacteria responsible for typhoid fever, paving the way for possible new vaccinations. ...

The Associated Press
Scientist: DNA led agents to anthrax suspect
The Associated Press - Aug 3, 2008
Using new genome technology, researchers looked at samples of cells from the victims to identify the kind of anthrax Ames strain that killed them, ...

Canada.com
Genetic discovery may lead to new blood test for people at high ...
Canada NewsWire (press release), Canada -
CNV refers to the variation in the number of copies (normally two) of a gene or sequences of DNA in the genome of an individual. The variations have been ...
HOSPITAL FOR SICK CHILDREN Canada NewsWire (press release)
all 38 news articles »

BBC News
Scientist: DNA led agents to anthrax suspect
The Associated Press - Aug 3, 2008
Using new genome technology to identify the type of Ames strain anthrax used in the attacks, the FBI began to focus on Ivins as its top suspect more than a ...
AssociatedPress
Q&A about anthrax and the investigation USA Today
DNA led to break in anthrax case Houston Chronicle
all 6,416 news articles »
Mystery Parrot Disease Virus Identified
ScienceBlogs -
Ultra high throughput sequencing was utilized to recover the complete viral genome sequence from one of the virus-positive PDD cases. ...
Source: Google News

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome -
T Nakagawa, Y Tanaka, E Matsuoka, S Kondo, Y Okada … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... Proteins (KIFs) in the Mouse Transcriptome Genome Res., June 1 ... Reprod, March 1, 2002;
66(3): 843 - 855. ... R. Lammers Characterization of KIF1C, a New Kinesin-like ...

Copy number variation: New insights in genome diversity -
JL Freeman, GH Perry, L Feuk, R Redon, SA … - Genome Research, 2006 - Cold Spring Harbor Lab
... Review. Copy number variation: New insights in genome diversity. Jennifer L.
Freeman 1 ,2 , George H. Perry 1 ,3 , Lars Feuk 4 , Richard ...

Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs -
WM Olivas, D Muhlrad, R Parker - Nucleic Acids Research - Oxford Univ Press
... currently predicted (1). Wehypothesizethatcarefulexaminationofotherregionsofthe
genome is likely ... of our 16 new RNAs correlated ... G. (1993) Cell, 75, 855?862. ...

A new DNA sequence assembly program -
JK Bonfield, KF Smith, R Staden - Nucleic Acids Res, 1995 - Oxford Univ Press
... The program also includes a new 'Directed Assembly' algorithm and ... Patterned Transcripts
in Drosophila Embryos Genome Res., July 1 ... April 1, 2002; 83(4): 855 - 872 ...

Proteome reference map of Pseudomonas putida strain KT2440 for genome expression profiling: distinct … -
S Heim, M Ferrer, H Heuer, D Regenhardt, M Nimtz, … - Environmental Microbiology, 2003 - Blackwell Synergy
... genome sequence (Nelson et al., 2002) provides a new framework for ... function (ECF)
sigma factors in the genome of Pseudomonas ... Environ Microbiol 4: 842? 855. ...

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and … -
DR Smith, LA Doucette-Stamm, C Deloughery, H Lee, … - J Bacteriol, 1997 - pubmedcentral.nih.gov
... 1994 Nov 11;243(5):846?855. ... genes in two regions of the Methanobacterium
thermoautotrophicum genome. ... winds of (evolutionary) change: breathing new life into ...

Sequence of the Bacillus subtilis genome region in the vicinity of the lev operon reveals two new … -
A Sorokin, A Bolotin, B Purnelle, H Hilbert, J … - Microbiology, 1997 - Soc General Microbiol
... The complete size of this ORF is 855 bp. ... The European Bacillus subtilis genome
sequencing project: current status and ... bility of the data from a new World Wide ...

Genome Dynamics, Evolution, and Protein Modeling in the Olfactory Receptor Gene Superfamily a -
D SHARON, G GLUSMAN, Y PILPEL, S HORN-SABARN, D … - Annals of the New York Academy of Sciences, 1998 - Blackwell Synergy
... LANCET (1998) Genome Dynamics, Evolution, and Protein Modeling in the Olfactory
Receptor Gene Superfamily a Annals of the New York Academy of Sciences 855 (1 ...

The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans -
BJ Loftus, E Fung, P Roncaglia, D Rowley, P Amedeo … - Science, 2005 - sciencemag.org
... Genome Technology Center, Stanford University, 855 California Avenue ... 5 Genome Sciences
Centre, 100-570 West 7th ... Hospital, 200 Henry Clay Avenue, New Orleans, LA ...

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus … -
D Gallahan, R Callahan - J. Virol, 1987 - pubmedcentral.nih.gov
... tumorigenesis in feral mice: identification of a new int locus ... in all species of
Mus, including mice lacking the virus proviral genome. ... 1982 Mar;41(3):855?867 ...

Source: Google Scholar
 

Highlights of the New Five-Year Plan (1998-2003) for the U.S. Human Genome Project

 

Human DNA Sequencing
  • Generate a working draft of 90 percent of the genome (2001) Obtain a complete, high-quality genomic sequence (2003)
  • Make all data publicly available
HGP planners at DOE and NIH emphasized that the highest priority of the Human Genome Project remains the same: to obtain and make publicly available a complete and highly accurate reference sequence. The new projected completion date was credited to recent advances achieved in technology and experience with pilot large-scale efforts as well as to the contributions of international partners in the sequencing effort, notably those of the Sanger Centre in the U.K., and research centers in Germany, Japan, and France.

NIH and DOE sequencing centers expect to generate about 60-70 percent of the human DNA sequence, which will be made available broadly and rapidly via the web to stimulate future research.

Article continues below and (thank you)
 

A new sequencing milestone expected by 2001 as a result of the scale-up is the generation of a "working draft" of 90 percent the genome that comprises shotgun sequence data from mapped clones, with gaps and ambiguities unresolved. If the data sets can be merged, private-sector sequencing efforts may help increase the depth of the mapped draft, which scientists expect will contain about half of the genes.

The continued emphasis on obtaining highly accurate sequence (1 error in 10,000 bases) that is largely continuous (few gaps) across each human chromosome, and the development of sustainable sequencing capacity underscores the critical importance of these resources for understanding human biology and for applications to other fields.

Sequencing Technology

  • Create a long-term, sustainable sequencing capacity by improving current technology and developing highly efficient novel technologies
Achieving the HGP goal will require current sequencing capacity to be expanded 2-3 times, demanding further incremental advances in standard sequencing technologies and improvements in efficiency and cost. For future sequencing applications, planners emphasize the importance of supporting novel technologies that may be 5-10 years in development.

Sequence Variation

  • Develop technologies for rapid identification of DNA sequence variants
A new priority for the HGP is examining regions of natural variation that occur among genomes (except those of identical twins). Goals specify development of methods to detect different types of variation, particularly the most common type called single nucleotide polymorphisms (SNPs) that occur about once every 1000 bases. Scientists believe SNP maps will help them identify genes associated with complex diseases such as cancer, diabetes, vascular disease and some forms of mental illness. These associations are difficult to make using conventional gene hunting methods because any individual gene may make only a small contribution to disease risk. DNA sequence variations also underlie many individual differences in responses to the environment and treatments.

Functional Genomics

  • Expand support for current approaches and innovative technologies
Efficient interpretation of the functions of human genes and other DNA sequences requires developing the resources and strategies to enable large-scale investigations across whole genomes. A technically challenging first priority is to generate complete sets of full-length cDNA clones and sequences for human and model organism genes. Other functional genomics goals include studies into gene expression and control, creation of mutations that cause loss or alteration of function in nonhuman organisms, and development of experimental and computational methods for protein analyses.

Comparative Genomics

  • Obtain complete genomic sequences for C. elegans (1998), Drosophila (2002), and mouse (2008).
A first clue toward identifying and understanding the functions of human genes or other DNA regions is often obtained by studying their parallels in nonhuman genomes. To enable efficient comparisons, complete genomic sequences already have been obtained for the bacterium E. coli and the yeast S. cerevisiae, and work continues on sequencing the genomes of the roundworm, fruit fly, and mouse. Planners note that other genomes will need to be sequenced to realize the full promise of comparative genomics, stressing the need to build a sustainable sequencing capacity.

Ethical, Legal and Social Implications (ELSI)

  • Analyze and address implications of identifying DNA sequence information for individuals, families, and communities.
  • Facilitate safe and effective integration of genetic technologies.
  • Facilitate education about genomics in nonclinical and research settings.
Rapid advances in genetics and applications present new and complex ethical and policy issues for individuals and society. ELSI programs that identify and address these implications have been an integral part of the US HGP since its inception. These programs have resulted in a body of work that promotes education and helps guide the conduct of genetic research and the development of related health professional and public policies.

Continuing and new challenges include safeguarding the privacy of individuals and groups who contribute samples for large-scale sequence variation studies; anticipating how resulting data may affect concepts of race and ethnicity; identifying how genetic data could potentially be used in workplaces, schools, and courts; commercial uses; and the impact of genetic advances on concepts of humanity and personal responsibility.

Bioinformatics and Computational Biology

  • Improve current databases and develop new databases and better tools for data generation and capture and comprehensive functional studies.
Continued investment in current and new databases and analytical tools is critical to the success of the Human Genome Project and to the future usefulness of the data. Databases must be structured to adapt to the evolving needs of the scientific community and allow queries to be answered easily. Planners suggest developing a human genome database analogous to model organism databases with links to phenotypic information. Also needed are databases and analytical tools for the expanding body of gene expression and function data, for modeling complex biological networks and interactions, and for collecting and analyzing sequence variation data.

Training

  • Nurture the training of genomic scientists and establish career paths.
  • Increase the number of scholars knowledgeable in genomics and ethics, law, or the social sciences.
Planners note that future genomics scientists will require training in interdisciplinary areas that include biology, computer science, engineering, mathematics, physics, and chemistry. Additionally, scientists with management skills will be needed for leading large data-production efforts.

Revised: October 29, 2003

Source: Office of Biological and Environmental Research, Human Genome Program
U.S. Department of Energy Office of Science
 
 
 
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