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Recent News and Articles on the Keywords: immunity boosts + boosts immunity + new  Related to the article below (Last Update: 8/5/2008)


Stuff.co.nz
Why breast is best
Stuff.co.nz, New Zealand - Aug 3, 2008
FEEDING TIME: Even the tiniest premature babies should get breast milk if possible because it boosts immunity against infections that can overwhelm their ...

The Beverage Network
Vital Action Performance Water: multi-functional flavored water ...
The Beverage Network -
Immunity: Echinacea is traditionally used to prevent infections and stimulates the immune system. In addition, the new action sports beverage also includes ...
History shows the value of vaccination
WA today, Australia -
... the resulting immunity is lifelong (as was the case with smallpox, one of the earliest vaccines ever trialled) but sometimes there is a need to "boost" ...
State boosts vaccination requirements for students
Wausau Daily Herald, WI - Aug 3, 2008
Researchers learned through additional studies that booster shots for chicken pox can help build immunity, Lamont said. Although older children and adults ...
Beneficial bacteria
Ottawa Citizen,  Canada - Aug 4, 2008
There's also data that some reduce the duration of the common cold and boost your general immunity. There are other things like a product I discovered, ...
3 Aug, 2008, 0221 hrs IST,Amitabh Baxi, ET Bureau
Economic Times, India - Aug 3, 2008
For instance, turmeric has direct anti-inflammatory properties, but also boosts the immunity in cancer patients. Most of the fruits, vegetables, ...
Broccoli and Cabbage Boost Immunity
Stop Aging Now, DC - Jul 17, 2008
The Anti-Aging Bottom Line: Maintaining robust immunity is critically important to living a long, healthy life. Try to include one serving a day of ...
FISA Bill Gets Unlikely Boost From Obama
The Conservative Voice, NC - Aug 1, 2008
What's better is that the reauthorization of FISA granted retroactive immunity to telecoms that cooperated with the government after the 9/11 attacks. ...
How Should the Next President Deal with the Bush White House's Crimes?
AlterNet, CA - Jul 26, 2008
So it actually gives privacy and civil liberties a big boost over the previous arrangement. It also does contain an immunity provision, which Senator Obama ...
ImClone says Bristol-Myers' bid is too low
Minneapolis Star Tribune, MN -
Sony Corp. said it will invest about 40 billion yen ($372 million) to boost its output capacity of lithium-ion batteries amid growing global demand. ...IMCL - BMY
Source: Google News

Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against … -
M Brisson, NJ Gay, WJ Edmunds, NJ Andrews - Vaccine, 2002 - Elsevier
... of herpes-zoster: a long-term study and a new hypothesis. ... Use of a live attenuated
varicella vaccine to boost varicella-specific immune responses in ...

… Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity … -
H McShane, AA Pathan, CR Sander, SM Keating, SC … - Nature Medicine, 2004 - nature.com
... might be used either after BCG in infants or to boost immunity in teenagers ... Another
target group for a new tuberculosis vaccine will be HIV-infected individuals ...

… and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses -
JW Hodge, JP McLaughlin, JA Kantor, J Schlom - Vaccine, 1997 - Elsevier
... 1 ,&i per well [3H]thymidine (New England Nuclear ... Enhanced antitumor immunity by
ALVAC-CEA: JW Hodge et al ... Prime and boost studies C57BW6 mice were immunized one ...

a-Fetoprotein-specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination … -
WS Meng, LH Butterfield, A Ribas, VB Dissette, JB … - Cancer Research, 2001 - AACR
... 4c) . View larger version (18K): [in this window] [in a new window], Fig. 4. DNA
prime and adenovirus boost immunization generate AFP-specific immunity. ...

The prime-boost strategy: exciting prospects for improved vaccination -
IA Ramshaw, AJ Ramsay - Immunology Today, 2000 - Elsevier
... human primate models for AIDS, New Orleans (1999). ... and S. Plotkin, The prime-boost
concept applied ... The relationship between humoral and cell-mediated immunity. ...

Nutritional Strategies to Boost Immunity and Prevent Infection in Elderly Individuals -
KP High - Clinical Infectious Diseases, 2001 - UChicago Press
... As we enter the new millennium, this ratio has increased to 1 in ... for many human
conditions, including heart disease and cancer, also boosts immune responses in ...

CD40 Activation Boosts T Cell Immunity In Vivo by Enhancing T Cell Clonal Expansion and Delaying … -
JR Maxwell, JD Campbell, CH Kim, AT Vella - The Journal of Immunology, 1999 - Am Assoc Immnol
... CD40 Activation Boosts T Cell Immunity In Vivo by ... 47K): [in this window] [in a new
window], FIGURE ... out to understand how SAg-induced T cell immunity is affected ...

INNATE IMMUNITY: Ancient System Gets New Respect -
T Gura - Science, 2001 - sciencemag.org
... If so, then something as simple as an amino acid supplement might boost immunity. ...
Download to Citation Manager. Alert me when: new articles cite this article. ...

… for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity … -
BJ Lamphear, JM Jilka, L Kesl, M Welter, JA Howard … - Vaccine, 2004 - Elsevier
... How to Cite or Link Using DOI (Opens New Window) Copyright ... an oral transmissible
gastroenteritis virus vaccine boosts lactogenic immunity in swine. ...

… Adenovirus Serotype 11 (Ad11) and Ad35 Vaccine Vectors in the Presence of Anti-Ad5 Immunity -
AAC Lemckert, SM Sumida, L Holterman, R Vogels, DM … - Journal of Virology, 2005 - Am Soc Microbiol
... reported that rAd35 vectors were immunogenic in the presence of anti-Ad5 immunity,
but the immunogenicity of heterologous rAd prime-boost regimens and the ...

Source: Google Scholar
 

New Peptide Boosts Body's Own Immunity

Article Date: 29 Mar 2007 - 4:00 PDT
Imagine the desperation of trying to fight lethal infections when antibiotics fail to work.

That scenario - commonly found with "hospital superbugs" - may well improve thanks to a discovery by a research team at the University of British Columbia, in collaboration with UBC spin-off company Inimex Pharmaceuticals, that has identified a peptide that can fight infection by boosting the body's own immune system.

"Antibiotics are now under threat because of the explosion in antibiotic-resistant bacteria. A third of all deaths on this planet are the result of infection so there is an urgent need to create new therapies," says Robert Hancock, principal investigator and Canada Research Chair in Pathogenomics and Antimicrobials. "The beauty of this peptide is that it acts on the host to trigger a protective response and doesn't act on bacteria directly. That means it's unlikely bacteria will become resistant to it."

The team found that a peptide, or chain of amino acids, they have dubbed innate defense regulator peptide (IDR-1), can increase innate immunity without triggering harmful inflammation, and offer protection both before and after infection is present.

Article continues below and (thank you)
 
The discovery, in animal models, is published in the journal Nature Biotechnology.

Researchers tested the peptide's effectiveness against Staphylococcus aureus including MRSA; a superbug called vancomycin-resistant Enterococcus (VRE); and Salmonella. In Staph and VRE infections, although bacteria were not completely eradicated, IDR-1 significantly reduced bacteria counts and mortality, when given either 24-48 hours before or four hours after infection began. In Salmonella, the peptide offered significant protection when administered prior to infection setting in.

Data showed that IDR-1 activates several signaling pathways to stimulate infection-clearing chemokines - a chemical mediator that mobilizes immune response.

In addition, the peptide did not produce harmful inflammation and toxicity often seen when the immune system is stimulated and, in fact, actually reduced the potentially harmful septic response. Sepsis, a consequence of a ravaging inflammatory response associated with infection, kills as many as 200,000 annually.

The innate immune response is the first line of defense against infection and comprises an interactive network of cellular and molecular systems that recognize and kill pathogens, as well as signaling pathways that trigger biological responses.

The researchers anticipate the therapy may be useful as a supplement to antibiotics in combating common hospital infections such as ventilator associated pneumonia, post-surgical infections, high dose chemotherapy and infections arising from insertion of catheters or other medical devices.

"We now have a powerful new tool that will allow us to stop infection before it starts - it's a new concept in treating infection," says Hancock.

The researchers estimate there are two million cases of antibiotic-resistant infection in hospitals that kill approximately 70,000 people annually in North America. Hospital-based methicillin-resistant Staphylococcus aureus (MRSA) alone causes an estimated 100,000 hard-to-treat infections annually and is now seen in community-based infections, such as boils and abscesses or life-threatening bloodstream infections.

"Salmonella causes 1.3 million infections and up to 100 deaths every year in the U.S. We're looking at a crisis in 10 years as most bugs will be resistant to most antibiotics. There's an urgent need to develop new tools," says Brett Finlay, a UBC microbiologist and an author on the paper. He and Hancock co-founded Inimex, which conducted many of the experiments required for the study.

Researchers expect it will be about 12-15 months before the discovery is introduced into human clinical trials.

###

Support for the research has been provided by the Canadian Institutes of Health Research (CIHR), Canada's major agency responsible for funding health research, and the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative, a U.S.-based project funded by the Bill & Melinda Gates Foundation, that has offered research grants totaling $436.6 million to achieve scientific breakthroughs against lethal diseases in the world's poorest countries.

Additional support has been provided by Genome Canada and Genome BC. Genome Canada is the primary funding and information resource relating to genomics and proteomics research in Canada. It has established six genome centres across the country, including Genome BC.

Inimex Pharmaceuticals, Inc. is a privately held biopharmaceutical company focused on development and commercialization of Innate Defense Regulator products, novel first-in-class drugs that selectively trigger the body's innate defenses without causing inflammation.

Contact: Hilary Thomson
University of British Columbia
 

Polish rally calls for even tougher abortion laws

Last Updated: 2007-03-28 13:40:54 -0400 (Reuters Health)

WARSAW - Thousands of demonstrators marched through Warsaw on Wednesday to demand Poland toughen its already strict abortion laws, pressing a case that has split the ruling conservative coalition government.

Police said 3,000 protesters from across the overwhelmingly Roman Catholic country attended the rally, calling for a change in the law to make it a crime to terminate a pregnancy even when a woman has been raped or her life is in danger.

The demonstration organised by the ultra-nationalist League of Polish Families, a minority party in the ruling coalition, and a fringe Catholic group, followed a decision by the European Court of Human Rights last week in favour of a Polish woman who nearly went blind after being denied an abortion.

The League and Catholic groups have called on the Polish government to fight the Strasbourg court's ruling and its decision to award compensation to the woman, saying abortion should be banned under any circumstances.

But the dominant conservative Law and Justice party has accepted the decision, opening up a split within the coalition.

Sociologist Marek Migalski at the University of Silesia said the turnout at the demonstration could be seen as a success for the organisers. A counter rally by supporters of women's groups arguing for more liberal abortion rules only drew around 1,000 in Warsaw on Wednesday, he said.

Poland has some of the toughest abortion laws in Europe. It allows a pregnancy to be interrupted only when it threatens the life or health of the mother, when the baby is likely to be permanently handicapped or when it originates from rape.

The League, which opposed Poland's European Union membership and has been accused of anti-Semitism by its opponents, wants even those exceptions closed and is pushing to change the constitution to this effect.

Prime Minister Jaroslaw Kaczynski's Law and Justice party has agreed to change the constitution to bolster the protection of unborn children but without making abortion rules tougher.

Police said both demonstrations were peaceful.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
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