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Recent News and Articles on the Keywords: new protein + autism + new  Related to the article below (Last Update: 7/1/2008)

Researchers Link Early Stem Cell Mutation To Autism
Science Daily (press release) -
The commonality is the protein's association in making new neurons." Collaborators were Drs. Hao Li, Shu-ichi Okamoto, Nobuki Nakanishi and Scott McKercher, ...
Early stem cell mutation linked to autism
Newstrack India, India -
"There's a yin and yang to this MEF2C protein. My laboratory recently showed that MEF2C induces embryonic stem cells to become neurons. In this new research ...
MicroRNAs Provide New Insight in Study of Autism, University of ...
AScribe (press release) - Jun 25, 2008
SANTA BARBARA, Calif., June 25 (AScribe Newswire) -- MicroRNAs may play an important role in the development of autism spectrum disorder, according to a new ...
Postech Unlocks Secret to Autism
코리아타임즈, South Korea - Jun 25, 2008
The new finding was published this week by Proceedings of the National Academy of Sciences. Professor Kim and his team have found that a shortage of protein ...
New drug offers hope for autism-related condition
The Post, Pakistan - Jun 23, 2008
The finding offers new hope for addressing learning disorders caused by autism. Using a mouse model for tuberous sclerosis complex (TSC), scientists at the ...
Researchers turn to genes to reduce heart damage Online - International News Network
all 5 news articles »

Washington Times
A new twist on autism education
Washington Times, DC - Jun 14, 2008
Many children on the autism spectrum are on a diet that eliminates gluten, the protein that is found in wheat and other grain products, and casein, ...
Missing Protein In Fragile X Syndrome Is Key To Transporting ...
Science Daily (press release) - Jun 9, 2008
A team of scientists has discovered new information about how FXS interferes with signaling between the nucleus of neurons and the synapse, ...
Losing sleep
Science News - Jun 26, 2008
... known as translational regulation. The new study may prompt more researchers to explore how protein production affects biological rhythms, she says.
Shedding New Light on Brain Evolution, Wellcome Trust Studies Role ...
Proteo Monitor, NY - Jun 12, 2008
... there?s no free lunch because the cost of having these new genes is mental illness. Some of these recently evolved genes went defective, produce autism, ...
Applied Biosystems/MDS Analytical Technologies Advance Proteomics ...
FOXBusiness - Jun 2, 2008
These new tools address the needs of scientists in industry and academia who are seeking to quantify many specific proteins and peptides in complex ...MDZ - ABI
Source: Google News

Autism New data suggest a new hypothesis -
GR DeLong - Neurology, 1999 - AAN Enterprises
... reviewed above, may shed some new light on ... CL, Steffenburg U, Kyllerman M. Autism
in Angelman ... syndrome : evidence for myelin basic protein haploinsufficiency. ...

The environment as an etiologic factor in autism: a new direction for research. -
EA London - Environmental Health Perspectives, 2000 - pubmedcentral.nih.gov
... Bolton P, Simonoff E, Yuzda E, Rutter M. Autism as a ... in X-linked MECP2, encoding
methyl-CpG-binding protein 2. Nat ... A new intellectual framework for psychiatry. ...

[CITATION] Autism and Autistic-like Conditions: Subclasses among Disorders of Empathy
CL Gillberg - Journal of Child Psychology and Psychiatry, 1992 - Blackwell Synergy

The neurobiology of autism: New pieces of the puzzle -
MT Acosta, PL Pearl - Current Neurology and Neuroscience Reports, 2003 - Springer
... E, Chakrabarti S: No evidence for a new variant of ... CK, Polley D, Robinson PD, et
al.: Autism and the ... HY: Rett syndrome: methyl-CpG-binding protein 2 mutations ...

… of 2q37. 3 deletion in autism and osteodystrophy: report of a case and of new markers for deletion … -
CC Genet - Logo, 2001 - content.karger.com
... Bryke CR: Deletion of 2q37 - a new syndrome ... sub-telomeric regions of children with
autism: Detection of ... neuronal cell death in KIF1A motor protein-deficient mice ...

DEVELOPMENT: New Hints Into the Biological Basis of Autism -
E Stokstad - Science, 2001 - sciencemag.org
... This gene codes for a protein that is thought to ... also have features that resemble
those of autism, such as ... School of Medicine and Dentistry in New York state ...

… scan for developmental dyslexia confirms linkage to chromosome 2p11 and suggests a new locus on 7q32 -
N Kaminen, K Hannula-Jouppi, M Kestila, P Lahermo, … - British Medical Journal, 2003 - jmg.bmj.com
... A new gene (DYX3) for dyslexia is located on ... Evidence supporting WNT2 as an autism
susceptibility gene. ... to the chicken neural cell surface protein Bravo/Nr-CAM ...

… of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family -
FA Cisternas, JB Vincent, SW Scherer, PN Ray - Genomics, 2003 - Elsevier
... of human CADPS and CADPS2, two new homologs of ... identify a C2 domain, a known protein
motif involved ... to contain a putative susceptibility locus for autism (AUTS1 ...

[PDF] Searching for genetic determinants in the new millennium -
NJ Risch - Nature, 2000 - hg-wen.uchicago.edu
... With the human genome sequence nearing completion, new opportunities are being
presented for ... on only a handful of blood group and serum protein markers with ...
-

Is autism a G-alpha protein defect reversible with natural vitamin A? -
MN Megson - Medical Hypotheses, 2000 - Elsevier
... both normal mice and blind mice easily learned the new path- way ... Autism may be a
disorder linked to the disruption of the G-alpha protein and the ...

Source: Google Scholar
 

New Protein Implicated In Autism

Article Date: 27 Mar 2007 - 15:00 PDT
Autism is a common neurodevelopmental disorder characterized by severely impaired social, communicative, and behavioral functions. It is thought that genetic make-up predisposes an individual to autism, and several genes have been associated with the development of autism. Although a region of human chromosome 7 has been identified to be associated with susceptibility to autism, none of the genes in this region had been directly implicated in the disorder until researchers from the RIKEN Brain Science Institute in Japan demonstrated that mice lacking the protein CADPS2 exhibited autistic-like characteristics.

In the study, which appears online in advance of publication in the April print issue of the Journal of Clinical Investigation, Teiichi Furuichi and colleagues show that mice lacking CADPS2, which is encoded by a gene in the autism susceptibility region of human chromosome 7, had impaired social interactions (when pairs of CADPS2-deficient mice that had never met were placed together they interacted substantially less frequently than pairs of wild-type mice that had never met), hyperactivity, and decreased exploration of a new environment; all of which are characteristics of individuals with autism. Importantly, an abnormal form of CADPS2 mRNA (which is an intermediate in the conversion of the CADPS2 gene to CADPS2 protein) was detected in some individuals with autism and was never detected in their healthy immediate relatives, leading to the suggestion that defects in CADPS2 function might predispose individuals to develop autism.

Article continues below and (thank you)
 
TITLE: Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

AUTHOR CONTACT:
Teiichi Furuichi
RIKEN Brain Science Institute, Wako, Saitama, Japan.

Contact: Karen Honey
Journal of Clinical Investigation
 

Tuberculosis: Fighting A Losing Battle - MSF Data Show Drug-Resistant TB Treatment Succeeds In Barely Half Of All Patients


Article Date: 27 Mar 2007 - 15:00 PDT
The international medical organization Doctors Without Borders/Médecins Sans Frontières (MSF) today released statistics showing that even under optimized conditions, treatment will succeed in barely more than half of patients with multi-drug resistant (MDR) Tuberculosis (TB). As insufficient research and development on new drugs and diagnostics has left health staff without the right tools to treat the disease, some patients will go on to develop extensively drug-resistant (XDR) TB regardless of the quality of care they are offered. The situation is particularly alarming when treating people co-infected with TB and HIV.

"When resistance emerges to the major TB drugs, we're forced to go back to using older, less effective ones", said Dr. Jessica Adam, a doctor in MSF's program in Uzbekistan. "This means a much longer, much more expensive treatment course that can cost up to US$15,000, and it means relying on drugs that are toxic: the side effects are simply horrible."

Since 1999, MSF has invested considerable resources and provided rigorous support to treat 570 patients with MDR TB in Armenia, Abkhazia, Georgia, Cambodia, Kenya, Thailand, Uganda, and Uzbekistan. Despite these efforts, only 55 percent of the patients completed the 18-24 month course of treatment. The remaining 45 percent died, did not improve with treatment, or defaulted because of side effects, isolation, and other difficulties in tolerating the treatment.

Diagnosing MDR-TB is also extremely difficult. Most resource-poor settings do not have access to the necessary sophisticated diagnostic equipment. But even in the best of settings that do possess the equipment, it can take up to eight weeks to obtain a result. For patients co-infected with HIV who are already ill, such delays can mean the difference between life and death.

"In places where we see a lot of HIV/AIDS, the risk of MDR-TB spreading like wildfire is a terrifying but all too likely prospect," said Dr. Liesbet Ohler, who works with MSF's program in Mathare, a slum near Nairobi, Kenya. "Treating MDR-TB and HIV simultaneously is incredibly frustrating because of drug interactions and the potential for many strong side effects, let alone the number of pills patients have to take every day. With the tools we have today, we're fighting a losing battle."

Last year's XDR epidemic in South Africa sparked international concern about the extent of the crisis and the urgency of finding solutions. Now, concrete actions need to be taken. The World Health Organization (WHO) needs to take the lead to develop new strategies against the disease.

Despite the urgency of the situation, current research efforts are not keeping pace with the need for better tests, drugs, and vaccines. An analysis conducted by MSF of the TB research and development pipeline found that none of the compounds under development today will be able to deliver the drastically shorter treatment that is needed to curb the disease. Similarly, the diagnostics under development will not be simple enough to use in resource-limited settings and will not reliably detect the disease. There is a critical funding gap for research and development for TB, with around $900 million needed annually, but only $206 million invested.

"MDR TB and now XDR TB are the tips of an iceberg of failing strategies to curb tuberculosis," said Dr. Tido von Schoen-Angerer, director of MSF's Campaign for Access to Essential Medicines. "We desperately need new tools and we need them now - we cannot just sit and wait. There is no quick, ready-made solution - but that is not an excuse not to act. One important step is to have all TB drugs in development tested in trials with MDR patients: this would be a quicker way to see whether new compounds are efficacious for patients with regular TB and give those with MDR a chance for better treatment," he said." At the moment, only one company has stated that it is planning to conduct an MDR trial while others sit on the fence. WHO needs to ensure that these trials will happen."

MSF is currently treating over 20,000 people with TB in more than 40 countries.

http://www.doctorswithoutborders.org
 
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Source for News : URL: http://www.medicalnewstoday.com and Reuters
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