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Article Date: 13 Mar 2007 - 4:00 PDT
Researchers from Harvard Medical School, Boston, have found that most individuals with acute myeloid leukemia (AML) inappropriately express a protein known as CDX2 in their leukemic cells. CDX2 regulates the expression of a number of genes that encode members of the HOX family of proteins, which might provide a new set of targets for the treatment of individuals with AML.
In the study, which appears online in advance of publication in the April print issue of the Journal of Clinical Investigation, Stefan Fröhling and colleagues show that the gene encoding CDX2 is expressed in 90% of the patients with AML that they analyzed. Moreover, reducing the amount of CDX2 in human AML cell lines decreased their ability to proliferate, indicating that CDX2 has a causal role in the pathogenesis of AML. Further evidence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 were induced to proliferate and were able to cause full-blown AML when transplanted into mice. Expression of CDX2 in the mouse hematopoietic cells induced altered expression of a number of genes that encode HOX family of proteins, leading the authors to conclude that aberrant expression of CDX2 drives the dysregulated HOX gene expression observed in most individuals with AML.
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TITLE: The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
AUTHOR CONTACT:
Stefan Fröhling
Brigham and Women's Hopsital, Harvard Medical School, Boston, Massachusetts, USA
Last Updated: 2007-03-12 13:59:45 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Helping frail older people to see more clearly may put them at increased risk of falls, according to a new study from Australia.
This could be because getting used to a new eyeglass prescription may throw people off balance, Dr. Robert G. Cumming, at Concord Hospital in New South Wales, and colleagues suggest. Whatever the explanation, they say the findings indicate that programs aimed at preventing falls among the elderly by improving their vision should be put on hold for now.
One previous study found that removing cataracts -- which allows people to see contrasts more clearly -- reduced falls among elderly people, but another found no effect, Cumming and his team note in the Journal of the American Geriatrics Society.
To better understand how improving elderly people's vision might affect fall risk, the researchers randomly assigned 616 men and women aged 70 and older to receive vision and eye exams, along with appropriate treatment, or to receive their usual care.
In the treatment group, 92 people got new eyeglasses, 24 had a home visit with an occupational therapist, 17 received glaucoma treatment, and 15 had cataract surgery.
However, during the following year, 65 percent of people in the treatment group fell at least once, compared to 50 percent of those in the control group. Thirty-one fractures occurred in the treatment group, while there were 18 among the untreated participants.
Overall, the men and women given vision treatment were 57 percent more likely to fall and 74 percent more likely to sustain fractures than those in the control group.
One explanation for the findings is that study participants needed a long time to adjust to new eyeglasses, Cumming and his team said. It's also possible, they add, that people in the treatment group who were given a clean bill of visual health became more active and took "unaccustomed risks."
While the findings must be confirmed by other researchers, Cumming and his team add, "it may be premature to implement the wide range of vision-related interventions to prevent falls proposed by others."
They also advise that eye care providers working with elderly people should be aware that their patients may be more prone to fall after receiving a new set of glasses. "They should prescribe conservatively and give appropriate advice about the need for caution during adaptation to new eyeglasses," the team concludes.
SOURCE: Journal of the American Geriatrics Society, February 2007.