Revolutionary new ways to tackle certain diseases could be provided by creating drugs which change the bugs in people's guts, according to a Perspective article published today in the journal Nature Reviews Drug Discovery.
Trillions of bugs known as gut microbes live symbiotically in the human gut. They play a key role in many of the processes that take place inside the body. Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity.
The authors of the Perspective argue that targeting gut microbes with new drug therapies, rather than concentrating on the mechanisms in the human body which are the current focus of most drug development programmes, could provide an array of uncharted possibilities for fighting disease. Much research is still needed to untangle the precise role played by each different type of bug.
Professor Jeremy Nicholson, one of the authors of the Perspective from the Department of Biomolecular Medicine at Imperial College London, explained: "It's only recently that we've discovered the huge influence that bugs in the gut have on people's health. The exciting thing about this is that it should be easier to create drugs that can change the bugs than it is to re-engineer human cells and signalling pathways inside the body. Also, if we're not interfering with the body's pathways, these drugs should have less toxic side-effects." |
