“The impact of cell cycle length on the formation of interneurons versus motoneurons was a surprising finding,” said Paul Trainor, Ph.D., Associate Investigator, and senior author on the publication. “Ongoing work involves global proteomic analyses aimed at identifying the complete set of Cux2-interacting partners. We believe these efforts will be essential to understanding how Cux2 elicits its multiple functions during neurogenesis.”
Further analysis of Cux2 will make it possible to extend these findings not only to spinal cord development, but also to the mammalian cortex, where Cux genes demarcate specific upper layers of cortical neurons and may have played a role in the expansion and increased complexity of the cortex during evolution.
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Additional contributing authors to this publication include Madhulik Sharma, Ph.D., University of Kansas Medical Center Postdoctoral Fellow; Michael Durnin, Stowers Institute Research Specialist II; and Greg Vanden Heuvel, Ph.D., University of Kansas Medical Center Associate Professor of Anatomy and Cell Biology.
Dr. Trainor also holds a faculty appointment in the Department of Anatomy & Cell Biology at The University of Kansas School of Medicine. Learn more about his research program at www.stowers-institute.org/labs/TrainorLab.asp.
About the Stowers Institute
Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.
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