They write: “We suggest Tax repression of replication-dependent histone gene expression will result in reactivation of viral gene expression, deregulation of cellular gene expression and genomic instability. All of these effects may contribute to the development of adult T-cell leukemia/lymphoma. To our knowledge, this is the first example of a reduction of histone levels correlating with viral infection and cancer development.”
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Notes to Editors
1. Human T-Lymphotropic Virus Type 1 Protein Tax Reduces Histone Levels
James M Bogenberger and Paul J Laybourn
Retrovirology (in press)
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