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York Mathematician Probes Geometric Route To Combat Viruses

Article Date: 08 Apr 2007 - 6:00 PDT
A mathematician at the University of York has been awarded a Research Leadership Award of more than £700,000 by the Leverhulme Trust to study the geometry of viruses.

Dr Reidun Twarock, an Anniversary Reader in the Departments of Biology and Mathematics, will study the structure and assembly of viruses, which will help to develop new anti-viral strategies.

Viruses have highly symmetrical external shells formed from proteins that encapsulate the viral genome. Dr Twarock has developed a method for encoding the structures of these protein shells that pinpoint the locations of the proteins and the bonds between them. With collaborators Professor Cristian Micheletti, from the International School for Advanced Studies (SISSA) in Trieste, Italy, and Professor Anne Taormina, from the University of Durham, she has used these results to model the assembly of viruses.

Subsequent work with collaborators Professor Peter Stockley, Dr Neil Ranson and their groups at the Astbury Centre for Structural Molecular Biology at the University of Leeds suggests that not only the geometry of the viral capsids themselves but also the full three-dimensional structures of the particles are constrained. The implications of this discovery on virus assembly are currently being investigated.

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