Iconocast Logo

Welcome To Iconocast

blank

Recent News on the Keywords, hiv spread + olive-pomace oil + hiv , Related to the Article Below:


RTE.ie
Finnish man wilfully spread HIV
RTE.ie, Ireland - 4 hours ago
A Finnish court has ruled that a man intentionally transmitted HIV, the virus that causes AIDS, to five women and had unprotected sex with at least 14 ...

The Cutting Edge
Country Marks World Malaria Day
AllAfrica.com, Washington - 6 hours ago
There are, however, no field studies that directly measure the effect of malaria on HIV spread. "HIV positive people living in malaria endemic areas and ...
Malaria-- New Tools Needed to Combat an Old Disease The Cutting Edge
all 4 news articles »
PEPFAR Reauthorization Bill To Benefit Malaria Efforts, Experts Say
Kaiser network.org, DC - 5 hours ago
... some global HIV/AIDS advocates say the PEPFAR reauthorization bill has "strayed too far from its original intent" of addressing the spread of HIV/AIDS ...
HIV+ man spread virus knowingly -Finnish court
Newsroom Finland, Finland - 8 hours ago
The Rovaniemi district court in northern Finland on Monday found that an HIV-positive man had knowingly infected five women with HIV. ...
Vietnam to offer heroin addicts methadone
Radio Australia, Australia - 4 hours ago
... has opened clinics offering drug users the substitute drug methadone, to help wean heroin addicts off injected drugs and reduce the spread of HIV/AIDS. ...
Remote service could halt HIV spread
The Age, Australia - Apr 9, 2008
A treatment model successful in reducing the transmission of HIV from mothers to their babies in remote Western Australia could be used in other countries, ...
PNG, Indonesia to cooperate in HIV spread
Radio Australia, Australia - Mar 31, 2008
Authorities in Papua New Guinea and Indonesia's neighbouring Papua province have agreed to cooperate in detecting and preventing the spread of HIV/AIDS. ...
South Africa: Women, Aids, And Violence, 1
AllAfrica.com, Washington - 2 minutes ago
... that while the immediate determinants of the spread of HIV relates to behaviours such as unprotected sexual intercourse, multiple sexual partnerships, ...

Afrik.com
Blackmen around the world victims of HIV spread
Afrik.com, France - Apr 18, 2008
This study observes the advantages of very comprehensive but short and accessible up-date information over its (HIV) spread, its prevention and its ...
Uganda: First Lady Warns On HIV Spread
AllAfrica.com, Washington - Mar 31, 2008
Mrs. Museveni said the ABC strategy is unique among policies to control the spread of HIV/AIDS because it emphasises behaviour change. ...
Source: Google News
 

A compound from olive-pomace oil gets 80% slowing down of HIV spread

- Researchers from the University of Granada and Hospital Carlos III in Madrid, verified that maslinic acid – found in wax from olive skin – inhibits serin-protease, the enzyme used by HIV to release itself from the infected cell into the extracellular environment.

C@MPUS DIGITAL Olive oil has become part of the fight against the Human Immunodeficiency Virus (HIV) – the cause of AIDS – thanks to the research carried out by the Bionat team, from the University of Granada, headed by Prof. Andrés García-Granados, senior lecturer in Organic Chemistry. Their work shows that maslinic acid – a natural product extracted from dry olive-pomace oil in oil mills – inhibits serin-protease, an enzyme used by HIV to release itself from the infected cell into the extracellular environment and, consequently, to spread the infection into the whole body. These scientists from Granada determined that the use of olive-pomace oil can produce an 80% slowing down in AIDS spreading in the body.

Maslinic or crataegolic acid is a pentacyclic terpene with antioxidant and anticancer effects found in wax from olive skin, alongside oleanolic acid. The effects of this compound in the fight against AIDS are simultaneously being studied in the UGR and in Hospital Carlos III in Madrid by a team headed by Prof. Vallejo Nájera.

Article continues below and (thank you)

 

Maslinic acid innovative properties stem from its powerful protease-inhibition activity, allowing researchers from Granada to register two patents on behalf of the UGR to produce drugs for treatment of diseases caused by protozoa Cryptosporidium – a parasite causing small intestine infection and diarrhoea – and by HIV. The University of Granada has already registered almost ten other patents related to this compound’s properties.

Maslinic acid is also a very active compound in opportunistic parasitic infections seriously affecting HIV patients.

In trials carried out by these researchers with the MT2 cell line, for concentrations of 25 and 30 µg/ml maslinic acid inhibited replication of a primary HIV-1 isolate. For 25 µg/ml a decrease in the cytopathic effect and in p24 antigen levels in the supernatant culture medium was detected. For 30 µg/ml, there was total absence of the cytopathic effect and also a decrease of p24 antigen levels.

Pilot Plant

The UGR Faculty of Sciences hosts a unique maslinic acid production pilot plant where the company MANINVEST S.L. – staffing scientists from the UGR departments of Organic Chemistry, Biochemistry and Parasitology, as well as a coordinating economist – is carrying out research on technology implementation and business programmes tuning aimed at making manitol and maslinic and oleanolic acids programmes more profitable.

Whilst manitol is obtained from olive oil waste water (alpechín) and olive-tree leaves, both acids are extracted from dry olive-pomace oil (orujo) produced at the olive-milling stage during olive oil elaboration process.

To this day, only oleanolic acid – produced in China – has been marketed. However, maslinic acid has gained importance as it is not still on the market and has a greater biological activity.

Prof. Andrés García-Granados’s team intends to continue working in the design and implementation of new maslinic acid by-products to fight against HIV, as well as in other innovative research projects financed by the Spanish Ministry of Science and Technology and the Andalusian Regional Government.


Reference:
Prof. Andrés García-Granados López de Hierro. Department of Organic Chemistry, University of Granada. Tel.: +34 958 24 33 64 / +34 958 24 33 20. E-mail: agarcia@ugr.es.

 

Peptide Found In Human Blood Inhibits 60 Strains Of HIV, Study Says

Article Date: 24 Apr 2007 - 3:00 PDT
A peptide found in human blood inhibited 60 strains of HIV from infecting cells in laboratory tests, according to a study published Thursday in the journal Cell, the San Francisco Chronicle reports. Researchers found the peptide can inhibit HIV strains that have developed resistance to existing medications --a discovery that could lead to the development of new HIV/AIDS drugs -- the Chronicle reports. Frank Kirchhoff of the University of Ulm in Germany and colleagues found the peptide, which they call VIRIP, in the residue left in filters used by kidney dialysis patients to clean their blood. According to Kirchhoff, by altering two amino acids, VIRIP's antiviral potency increased one hundredfold. VIRIP attacks a protein, called GP-41 and found on the surface of HIV, that the virus uses to penetrate the surface of human cells, the Chronicle reports. According to Warner Greene, director of the Gladstone Institute of Virology and Immunology who was not involved with the study, VIRIP stands out because it is collected from human blood. He added that the peptide might work synergistically with the antiretroviral drug Fuzeon, which also is known as enfuvirtide or T-20 and was approved by FDA in March 2003. Greene said that it is possible that VIRIP also has potential as an active ingredient for microbicides, which include gels, foams and creams that could be applied prior to sexual intercourse to prevent the sexual transmission of HIV and other sexually transmitted infections.

VIRIP can be manufactured in lab settings and has been licensed by the German biotechnology company Viro Pharmaceuticals, whose scientific director is a co-author of the study. According to the Chronicle, Viro is conducting animal studies to determine if VIRIP is safe to test among humans. Although the results so far "look promising," it will take at least five years of animal and human trials before a drug implementing VIRIP is available, according to Kirchhoff.

Reaction
According to the Chronicle, VIRIP likely will be more costly to produce and will have to be injected because it is a peptide -- a larger and more complex chemical structure than medications made up of chemical compounds. Although the "big advantage of [VIRIP] is that it is available in huge quantities," a "peptide is obviously not ideal" for treating HIV, Kirchhoff said. He added that he hopes additional research will determine how smaller chemical compounds can be created that would perform just as well and in the same way as VIRIP. "In the long-run, we must go away from peptides," he said (Russell, San Francisco Chronicle, 4/20). Roger Pebody, a treatment adviser at the Terrence Higgins Trust, said, "This is early stage research but may be very useful in developing a new class of HIV drugs." He added, "It may take years, but let's hope that this leads to an effective future treatment for HIV" (BBC News, 4/20).

The study is available online.

"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

 

New Insight Into HIV Infection

Article Date: 27 Apr 2007 - 1:00 PDT

Scientists provide new information about how HIV, the virus that causes AIDS, enters the nucleus of an infected cell. This study could help devise a new way to fight AIDS.

When HIV infects a cell, it carries its DNA into the nucleus of the cell, then the viral DNA mixes with the cell's DNA. The combined DNA produces proteins that make new viruses, which spread to neighboring cells. The mechanism by which HIV's DNA enters the nucleus is not yet fully understood and may offer new ways to fight HIV.

Xiaojian Yao and colleagues studied how various cellular proteins help the virus enter the infected cell's nucleus. They revealed new roles for these proteins that had not been fully established. The study also showed that by silencing genes that produce one of these proteins, HIV was three times less infectious than when the protein was present.

Article:
"Interaction of Human Immunodeficiency Virus Type 1 Integrase with Cellular Nuclear Import Receptor Importin 7 and its Impact on Viral Replication"
by Zhujun Ao, Guanyou Huang, Han Yao, Zaikun Xu, Meaghan Labine, Alan W. Cochrane, and Xiaojian Yao

The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 11,900 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society's student members attend undergraduate or graduate institutions.

Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.

For more information about ASBMB, see the Society's Web site at www.asbmb.org
 
Google
Web www.iconocast.com
 
 New Mailman School Study Shows Inevitability of Men’s Infidelity Across Cultures

--Marital sex single greatest HIV risk for women aound the world--


May 7, 2007 – For a growing number of women in rural Mexico – and around the world – marital sex represents their single greatest risk for HIV infection. According to a new Mailman School of Public Health Study, because marital infidelity by men is so deeply ingrained across many cultures, existing HIV prevention programs are putting a growing number of women at risk of developing the HIV virus. The findings, indicating that globally, prevention programs that take a “just say no” approach and encourage men to be monogamous are unlikely to be effective, underline the need for programs that make extramarital sex safer, rather than—unrealistically—trying to eradicate it. These findings are published in the June 2007 issue of the American Journal of Public Health .

The article’s lead author, Jennifer S. Hirsch, PhD, associate professor of Sociomedical Sciences at Columbia University Mailman School of Public Health, is principal investigator on a large comparative study showing that the inevitability of men’s infidelity in marriage is true across cultures. This was borne out in the research conducted in rural Mexico as well as in similar studies she is overseeing in rural New Guinea and southeastern Nigeria, which are published in the same issue of the American Journal of Public Health. Two additional studies underway, in Uganda and Vietnam, are expected to show similar results.

The Mexico study was based on six months of anthropological research, including participant observation, 20 marital case studies, 37 key informant interviews, and document analysis to explore the factors that shape HIV risk among married women in Degollado, one of the Mexico’s rural communities.

In rural Mexico, reputation is a critical aspect of sexual identity, and attention to reputation provides insight into why people act in ways that are socially safer, but physically risky. “What we found in our research was that culturally constructed notions of reputation in this community led to sexual behavior designed to minimize men’s social, rather than viral, risks,” said Dr. Hirsch. “We also saw that men’s desire for companionate intimacy actually increases women’s risk for HIV infection.”

A major factor in the study was that married men in the community left their homes to travel to the United States or large Mexican cities to find work. While away for long periods, they engaged in extra-marital and unsafe sex, which can lead to HIV infection. When men return home, they are said to be on honeymoon again, which includes resuming marital sexual relations.

“The result is that women are infected by their husbands, the very people with whom they are supposed to be having sex and, according to social conventions of Mexico, the only people with whom they are ever supposed to have sex,” said Dr. Hirsch. “This challenges existing approaches to HIV prevention. It renders abstinence impossible and unilateral monogamy ineffective. Marital condom use is also not a serious option, because of women’s deep, culturally supported commitment to the fiction of fidelity.”

In New Guinea, researchers also saw labor migration as a major contributor to infidelity. Moreover, many men did not view sexual fidelity as necessary for achieving a happy marriage, but they viewed drinking and “looking for women” as important for male friendships.

In the Nigerian study, the social organization of infidelity was shaped by economic inequality, aspirations for modern lifestyles, gender disparities, and contradictory moralities. There, it is men’s anxieties and ambivalence about masculinity, sexual morality, and social reputation in the context of seeking modern lifestyles – rather than immoral sexual behavior and traditional culture – that exacerbate the risks of HIV/AIDS.

According to Dr. Hirsch, the policy implications of these findings are clear. “This study has direct implications for the types of prevention programs we should be supporting,” she observes. “We might find men’s persistent and widespread participation extramarital sex to be troubling – but it’s a deeply rooted aspect of social organization, and one that is unlikely to be easily changed. Public health programs alone can’t stop extramarital sex, so we need to think about how to reduce the risk. Saying that ‘be faithful’ will protect married women is not true – unilateral monogamy is not an effective prevention strategy.”

About the Mailman School of Public Health
The only accredited school of public health in New York City, and among the first in the nation, Columbia University's Mailman School of Public Health provides instruction and research opportunities to more than 950 graduate students in pursuit of masters and doctoral degrees. Its students and more than 300 multi-disciplinary faculty engage in research and service in the city, nation, and around the world, concentrating on biostatistics, environmental health sciences, epidemiology, health policy and management, population and family health, and sociomedical sciences. www.mailman.hs.columbia.edu

 

Stephanie Berger
212-305-4372
sb2247@columbia.edu

 

 
Source for News : URL: http://www.medicalnewstoday.com and Reuters
 


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Disclaimer

Negación

Home

Contact Iconocast

Keywords: