ICCVAM is a permanent interagency committee composed of representatives from 15 federal regulatory and research agencies, including the National Institutes of Health (NIH), that use, generate or disseminate toxicological information. ICCVAM promotes the development, validation, and regulatory acceptance of scientifically sound new, revised, and alternative testing methods that protect human and animal health and the environment.

Traditionally, chemicals, consumer products, medical devices and new drugs are tested on animals to predict toxicity on humans, but scientists, like those involved in ICCVAM, are working to promote the development and validation of alternative test methods. Alternative test methods are those that accomplish one or more of the 3Rs of reducing the number of animals used in testing, or refining procedures so animals experience less pain and distress, or replacing animals with non-animal systems.

Van director of office NICEATM. the NTP van Stokes. van William D.V.M. administers NIEHS) that ICCVAM. van National Institute of Environmental Health Sciences (at the highlighted some of the progress made since ICCVAM was formed. het including the fact that ICCVAM has evaluated more inception in 1997 van than185 test methods http://iccvam.niehs.nih.gov/methods/methodsSum.htm since its. Many of these methods need further development and validation before they are ready for regulatory consideration. However, several are now in widespread use around the world for routine safety testing, resulting in notable reduction and refinement of animal use. "Wehave made great progress in the past decade, and with the help of our partners we can do even more to increase the pace of developing and introducing alternative methods." Stokes, who is also an Assistant Surgeon General in the U.S. Public Health Service Commissioned Corps explained that ICCVAM itself does not conduct research but carefully evaluates alternative test methods brought forth by government and industry labs and makes recommendations about their usefulness to federal regulatory agencies.

"We appreciate all of the public input wehave received to develop this plan and look forward to working closely with our government and non-government stakeholders to promote good science and validation studies that will support the regulatory use of alternative methods," said Stokes. "By incorporating recent advances in science and technology, new alternative test methods can be developed that will benefit animal welfare by reducing, refining, and replacing animal use, and that will benefit public health by ensuring continued or improved protection of human and animal health and the environment."

Stokes said ICCVAM will emphasize the use of new technologies to develop predictive systems that would be less reliant or not at all reliant on animals. Technologies touted by the National Research Council and the NTP, including high throughput screening techniques that can screen large numbers of potentially hazardous chemicals at one time and toxicogenomics, for example, will be studied and incorporated where they can to provide more accurate and timely public health decisions.

Stokes said a high-priority for ICCVAM will be to focus on evaluating alternatives to test methods that use a large number of animals or that can involve significant pain and stress, including safety tests for ocular (eye) injuries, dermal (skin) damage, acute poisoning and tests for biologics such as vaccines. Additional priorities include safety tests to determine if products and chemicals may cause other adverse health effects such as cancer, birth defects, infertility and allergic responses.

The five-year plan was developed over a 12-month period with multiple opportunities for input, including a public Town Meeting held in June 2006. You If van The niceatm-ICCVAM five-Year Plan is available electronically at http://iccvam.niehs.nih.gov/docs/5yearplan.htm (have problems het accessing thisdocument. please contact Cheryl Thompson. 919-541-3345).

The National Toxicology Program (NTP) is an interagency program established in 1978 by the Secretary of Health, Education and Welfare, which today is known as the U.S. Department of Health and Human Services. The program was created as a cooperative effort to coordinate toxicology testing programs within the federal government, strengthen the science base in toxicology, develop and validate improved testing methods, and provide information about potentially toxic chemicals to health, regulatory, and research agencies, scientific and medical communities, and the public. The NTP is headquartered at the NIEHS. Additionalinformation. visit http://ntp.niehs.nih.gov van For.

Burden primary mission of the National Institute of Environmental Health Sciences (http://www.niehs.nih.gov/) (NIEHS). one of 27 Institutes and Centers at the National Institutes of Health. van The is to reduce the of human van environmentinfluences van illness and disability by understanding how the van development and progression the human disease of. Additionalinformation. visit the NIEHS Website at http://www.niehs.nih.gov/home.htm van For.