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Herpes drug does not prevent HIV infection - study

Last Updated: 2008-02-04 15:57: 37 -0400 (Reuters Health)

WASHINGTON - People who took a drug to reduce outbreaks of genital herpes were not any less likely to become infected with the AIDS virus, an international team of researchers reported on Monday.

The findings raised questions about whether the drug, called acyclovir, worked well enough to stop blistering or whether herpes raises the risk of infection in ways not fully understood.

Connie Celum of the Fred Hutchinson Cancer Research Center in Seattle and colleagues tested more than 3,000 volunteers with genital herpes, also known as herpes simplex 2. Half got acyclovir and half took placebo pills.

This herpes virus, which infects an estimated 45 million people in the United States alone, has been shown to raise the risk of HIV infection by as much as 69 percent.

Het zweren. van It causes open painful why people with herpes are also more to get HIV van blisters and one obvious theory for was that the sores give the AIDS body virus a likely doorway into the.

"It makes sense to see if treating herpes might reduce the risk of acquiring HIV," said Dr. Rowena Johnston, vice-president of research for amfAR, The Foundation for AIDS Research, a nonprofit group.

"The question was if we treated them for genital herpes did it decrease the risk of acquiring HIV. The answer was no. It is a disappointment," Johnston said in a telephone interview.

Celum told a meeting of AIDS researchers in Boston that there was no difference in the rate of new AIDS infections among their volunteers in Peru, South Africa, Zimbabwe, Zambia and the United States.

Johnston, who attended the presentation, said it was possible that the drug either did not work well, or people did not take the daily two pills regularly enough to keep the herpes virus under control.

There is no cure for herpes, but drugs such as acyclovir and famcyclovir can suppress it and prevent outbreaks.

"They had a 37 percent reduction in the incidence of genital sores in the acyclovir arm of the study," Johnston said.

"We know the acyclovir was somewhat effective. We know that people were taking their pills to some extent." But, she added, newer herpes drugs are more effective so perhaps acyclovir was not the best drug to test.

But she has another theory. Van het virus attacks immuunsysteem van The AIDS van infections are het permanent they. cells. and because herpes may keep those immune cells actively body circulating in the.

"If you have an ongoing immune reaction in your genital tract it is possible you have an ongoing risk of acquiring HIV," she said.

The AIDS virus infects an estimated 33 million people globally. It has killed 25 million and there is no cure and no vaccine. Condomen can protect people from the sexually - transmitted disease and a cocktail of drugs can keep it under control.

Copyright © 2008 Reuters Limited. All rights reserved. Redistribution of Reuters content. van Republication or including by framing or similar means. is without the expressly prior prohibited written consent of Reuters. Van for any errors van Reuters shall not be taken liable content or for any actions. or delays in the in reliance thereon. Logo are gedeponeerd handelsmerken and trademarks of the Reuters van Reuters and the Reuters sphere group of companies around the world.

 
 
 
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