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4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats

WESTCHESTER, Ill. - Four days' exposure to a REM sleep deprivation procedure reduces cell proliferation in the part of the forebrain that contributes to long-term memory of rats, according to a study published in the February 1 issue of the journal SLEEP.

The study. by Dennis McGinty. Doctoraat. of the V.A. Greater Los Angeles Healthcare System. authored focused on male Sprague -sprague-dawley-rats. REM sleep deprivation was achieved by a brief treadmill movement initiated by automatic online detection of REM sleep. A yoked-control (YC) rat was placed in the same treadmill and experienced the identical movement regardless of the stage of the sleep-wake cycle.

According to the results, REM sleep was reduced by 85 percent in REM sleep deprived rats and by 43 percent in YC rats. Cell proliferation was reduced by 63 percent in REM sleep deprived rats compared with YC rats. Across all animals, cell proliferation exhibited a positive correlation with the percentage of REM sleep.

"Several studies have shown that sleep contributes to brain plasticity in general , and to adult neurogenesis, in particular," said Dr. McGinty. "Neurogenesis is a concrete example of brain plasticity, suppression of adult neurogenesis is thought to be important in pathologies such as depression. One current question has to do with the relative contribution of the two sleep states, non-REM and REM, which have very different, even opposite, physiological properties. This study showed that REM sleep has a critical role in facilitating brain plasticity. The study does not exclude an equally important role for non-REM sleep. In other recent work, we have shown that sleep fragmentation can also suppress adult neurogenesis. How sleep affects the molecular mechanisms underlying neurogenesis remains to be explored."

It is recommended that older adults get between seven and eight hours of nightly sleep.

Van offers the following tips on how to van American Academy of Sleep Medicine (van The AASM) nachtrust: get a good

  • Consistent de bedtijdroutine van Follow a.

  • De relaxing setting at bedtijd van Establish a.

  • De nachtrustevery van Get a full night.

  • Van caffeine. as well as van Avoid foods or drinks that contain bedtijd van medicine that has a stimulant prior to. de any.

  • Do not bring your worries to bed with you.

  • Do not go to bed hungry. but do not eat a big meal beforebedtijd either.

  • Any exercise rigorous van Avoid within six hours of your bedtijd.

  • Make your bedroom quiet, dark and a little bit cool.

  • Get up at the same time every morning.

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Those who suspect that they might be suffering a sleep disorder are encouraged to consult with their primary care physician or a sleep specialist.

SLEEP is the official journal of the Associated Professional Sleep Societies, LLC, a joint venture of the AASM and the Sleep Research Society.

SleepEducation.com. a created patient education Website by the AASM. provides van disorders. the forms of treatment van information about various sleep available recent news. on the topic of sleep. sleep studies that have conducted and a listing of sleep facilities. been

Entitled copy ofthis article. van For a. „Rapid eye van reduction of neurogenesis van movement sleep deprivation contributes to van de dentatehersenplooiing in the please hippocampal of the adult rat“. or to arrange an interview with an AASM study. contact Jim Arcuri. de public relationscoordinator. at (708) 492-0930. ext. 9317. or jarcuri@aasmnet.org van de woordvoerder regarding this.

 
 
 
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